The impact of albumin conjugation on the cytotoxic properties of cisplatin, oxaliplatin and auranofin in cancer cells
Valentina
Vitali, 
†a
Lorenzo
Chiaverini,
†b
Mirko
Severi,
a
Luigi
Messori,
*a
Lara
Massai,
*a
Tiziano
Marzo
*b
and
Chiara
Giacomelli
b
†a
Lorenzo
Chiaverini,
†b
Mirko
Severi,
a
Luigi
Messori,
*a
Lara
Massai,
*a
Tiziano
Marzo
*b
and
Chiara
Giacomelli
b
Abstract
The role of human serum albumin (HSA) in the delivery of anticancer metallodrugs remains unclear and requires further investigation. To this end, bioconjugates of HSA with the metallodrugs cisplatin (CIS), oxaliplatin (OXA) and auranofin (AF) were prepared, characterised by ESI-MS and ICP, and tested for their cytotoxic properties in A2780 and HCT116 cancer cells. Significant differences in the biological activities of the two Pt bioconjugates compared to that of the Au bioconjugate emerged, and they are interpreted and discussed in the context of the available literature.
- This article is part of the themed collection: Special collection for the 11th Asian Biological Inorganic Chemistry Conference
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