Visible light-induced PPh3/MI-promoted δ-C(sp3)–H chlorination and cyclization with N-chloro-arylsulfonamides via EDA complexes

Abstract

Triphenylphosphine, iodide and N-chloro-arylsulfonamides could generate amidyl radicals via EDA (Electron Donor–Acceptor) complexes under visible light irradiation, and this strategy enables the synthesis of valuable δ-chloro-arylsulfonamide and N-arylsulfonylpyrrolidine motifs in moderate yields. This blue LED-induced method utilizes more readily available reagents, providing advantages in terms of cost efficiency, broad substrate scope, and functional-group compatibility.