Issue 18, 2022

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

Abstract

Autophagy is an evolutionarily conserved catabolic process that can degrade cytoplasmic materials and recycle energy to maintain metabolite homeostasis in cells. Autophagy is closely related to various physiological or pathological processes. Macromolecular materials are widely used in drug delivery systems and disease treatments due to their intrinsic effects, such as altered pharmacokinetics and biodistribution. Interaction of autophagic flux or the signal pathway with macromolecules may cause autophagy inhibition or autophagy cell death. This review covers autophagy regulation pathways and macromolecular materials (including functional micelles, biodegradable and pH-sensitive polymers, biomacromolecules, dendrimers, coordination polymers, and hybrid nanoparticles) mediated autophagy modulation.

Graphical abstract: Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

Article information

Article type
Review Article
Submitted
06 июн 2022
Accepted
18 июл 2022
First published
20 июл 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 3676-3688

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery

C. Wang, Y. Li, Y. Tian, W. Ma and Y. Sun, Nanoscale Adv., 2022, 4, 3676 DOI: 10.1039/D2NA00355D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements