Issue 31, 2020

Antioxidant shape amphiphiles for accelerated wound healing

Abstract

Shape amphiphiles refer to a class of molecular conjugates composed by distinct building blocks with incommensurate shapes and chemical interactions. Whilst extensive efforts have been devoted to the solid state self-assembly and nanolithography applications of shape amphiphiles, only very limited examples of their usage in the biomedical field have been explored. In this work, we reported a series of gallic acid functionalized polyhedral oligomeric silsesquioxane (POSS)-based shape amphiphiles with various macromolecular architectures for efficient and accelerated wound healing. These antioxidant giant amphiphiles demonstrated good biocompatibility and strong free radical scavenging activity to prevent cell oxidative damage and then promote wound recovery. We describe these POSS-based antioxidant shape amphiphiles in an initial proof-of-concept study and propose that this family of functional giant amphiphiles will be useful in regenerative biomedicine.

Graphical abstract: Antioxidant shape amphiphiles for accelerated wound healing

Supplementary files

Article information

Article type
Paper
Submitted
03 мар 2020
Accepted
25 июн 2020
First published
15 июл 2020

J. Mater. Chem. B, 2020,8, 7018-7023

Antioxidant shape amphiphiles for accelerated wound healing

Z. Li, J. Zhang, Y. Fu, L. Yang, F. Zhu, X. Liu, Z. Gu and Y. Li, J. Mater. Chem. B, 2020, 8, 7018 DOI: 10.1039/D0TB00578A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements