Issue 11, 2020

Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

Abstract

Acetalization of aldehydes is an area of great importance in Organic Chemistry for both synthetic and biological puproses. Herein, we report a mild, inexpensive and green photochemical protocol, where Schreiner's thiourea (N,N′-bis[3,5-bis(trifluoromethyl)-phenyl]-thiourea) is utilized as the catalyst and cheap household lamps as the light source. A variety of aromatic and aliphatic aldehydes were converted into acetals in good to high yields (23 examples, 36–96% yield) and an example of the synthesis of a cyclic acetal is provided. The reaction mechanism was also studied.

Graphical abstract: Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

Supplementary files

Article information

Article type
Paper
Submitted
30 мар 2020
Accepted
06 май 2020
First published
06 май 2020
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2020,22, 3539-3545

Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

N. Spiliopoulou, N. F. Nikitas and C. G. Kokotos, Green Chem., 2020, 22, 3539 DOI: 10.1039/D0GC01135E

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