Issue 9, 2019

Catalysis in medicinal chemistry

Abstract

The advent of transition-metal catalysis (and likewise, bio-catalysis, photoredox-catalysis and organo-catalysis, etc.) promises to greatly increase access to diverse chemical matter in medicinal chemistry, but new catalytic reactions often fail to deliver product in applied synthesis. In order to deliver on the promise of catalysis, we need to learn how to use it to prepare the types of molecules that are relevant in biological systems. The dimensionality of trying to understand the rules for what causes catalysis to fail on diverse new substrates is a daunting problem that requires systematic, simplified thought. This perspective suggests an organized course of action to enable the generation of data to understand how to turn on catalysis for efficient synthesis of diverse molecules in medicinal chemistry.

Graphical abstract: Catalysis in medicinal chemistry

Article information

Article type
Perspective
Submitted
12 фев 2019
Accepted
08 апр 2019
First published
25 апр 2019

React. Chem. Eng., 2019,4, 1530-1535

Catalysis in medicinal chemistry

S. D. Dreher, React. Chem. Eng., 2019, 4, 1530 DOI: 10.1039/C9RE00067D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements