Issue 57, 2016

Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes

Abstract

This feature article describes the development of synthetic zinc(II)-dipicolylamine (ZnDPA) receptors as selective targeting agents for anionic membranes in cell culture and living subjects. There is a strong connection between anionic cell surface charge and disease, and ZnDPA probes have been employed extensively for molecular imaging and targeted therapeutics. Fluorescence and nuclear imaging applications include detection of diseases such as cancer, neurodegeneration, arthritis, and microbial infection, and also quantification of cell death caused by therapy. Therapeutic applications include selective targeting of cytotoxic agents and drug delivery systems, photodynamic inactivation, and modulation of the immune system. The article concludes with a summary of expected future directions.

Graphical abstract: Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes

Article information

Article type
Feature Article
Submitted
02 май 2016
Accepted
09 июн 2016
First published
15 июн 2016

Chem. Commun., 2016,52, 8787-8801

Imaging and therapeutic applications of zinc(II)-dipicolylamine molecular probes for anionic biomembranes

D. R. Rice, K. J. Clear and B. D. Smith, Chem. Commun., 2016, 52, 8787 DOI: 10.1039/C6CC03669D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements