Issue 23, 2018

A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Abstract

Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(III) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

Graphical abstract: A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Supplementary files

Article information

Article type
Communication
Submitted
10 мар 2018
Accepted
14 май 2018
First published
15 май 2018

J. Mater. Chem. B, 2018,6, 3855-3858

A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift

J. Liu, K. Vellaisamy, G. Li, C. Yang, S. Wong, C. Leung, S. Pu and D. Ma, J. Mater. Chem. B, 2018, 6, 3855 DOI: 10.1039/C8TB00666K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements