Chuan-Qi Duan, Xiao-Long He, Wei Du and Ying-Chun Chen
Org. Chem. Front., 2018,5, 2057-2060
DOI:
10.1039/C8QO00351C,
Research Article
The dearomatizative dienamine-type intermediates between 2-benzyl-3-furfurals and a chiral secondary amine underwent asymmetric [4 + 2] cycloadditions with α-cyano-chalcone-type substrates, affording tetrahydrobenzofurans having dense substitutions and multiple stereogenic centers with high to outstanding results (up to 92% yield, >99% ee, >19 : 1 dr).
![Graphical abstract: Asymmetric [4 + 2] cycloadditions with 3-furfural derivatives and α-cyano-α,β-unsaturated ketones](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C8QO00351C "Graphical abstract")
