A bifunctional squaramide catalyzes the enantioselective arylation of isoxazolin-5-ones with o-quinone diimides (o-QDIs) to give isoxazolin-5-ones featuring an arylated quaternary stereocenter in high yields and excellent enantioselectivities.
Diacetyliminoxyl is introduced as the first synthetically available oxime radical for fundamental mechanistic studies, oxidative functionalization and dehydrogenation processes.
Over the past 25 years, the isoxazoline route to aldols has proven to be a powerful synthetic tool. This review discusses more than 50 syntheses of natural products, including macrolides, alkaloids, terpenoids, pseudosugars, and sulfolipids.
Electrophilic aromatic substitution at the C5 position of isoxazolines and construction of a new quaternary carbon center were achieved in this paper.
1,2-N/O heterocycles hold great promise for exhibiting diverse pharmacological activities. This review summarizes an overview of recent methods (up to 2024) for the synthesis of these heterocycles starting from alkynyl hydroxylamines.