A visible-light-promoted metal-free radical cascade cyclization reaction has been developed with 3-allyl-2-arylquinazolinones as a new class of radical acceptor.
We identified a potent and selective antitrypanosomal agent through modulation of the mechanism of action of a 2-arylquinazoline scaffold as an antitrypanosomal agent via chemical functionalization at the 4-position.
This article reviews the recent advances in the transition metal-catalyzed sulfonamidation and phosphoramidation of a variety of organic compounds. It also covers fundamental concepts and mechanistic aspects, including key intermediates and reaction pathways.
Diaryl acetylenes undergo spiroannulation with 4-arylquinazolin-2-ones to afford spiro[indene-1,4′-quinazolin]-2′(3′H)-one frameworks. This is the first report on the spiroannulation of 4-arylquinazolin-2-ones with alkynes.
A convenient Cu-catalyzed synthesis of 2-arylquinazolin-4(3H)-one derivatives has been developed using simple starting materials such as 2-nitrobenzonitriles and alcohols under mild conditions.