In this Highlight, the convergent synthetic approaches that yield the highly functionalized, complex molecular architecture of Veratrum steroidal alkaloids are discussed.
This review highlights key C–C bond formation and reorganization reactions in the construction of steroidal skeletons, as well as redox-relay events for the installation of complex oxidation states of steroid natural products.
The broad use of natural products and the accompanied incidences of gastrointestinal injury have attracted considerable interest in investigating the responsible toxic ingredients.
The Wieland–Miescher ketone (WMK) has cemented its position as a cornerstone in the field of total synthesis, enabling the efficient construction of complex and bioactive natural products.
The oxidation reactions employed in selected total syntheses from 2020 to 2025 are surveyed to reflect their current status, guide planning in total syntheses, and prompt organic chemists to develop more efficient oxidation reactions and reagents.