We report the design, synthesis, and mechanistic study of a novel series of 2-piperazineone peptidomimetics as HIV capsid modulators by mimicking the structure of host factors binding to CA.
A highly efficient, one-step stereo- and regioselective conversion of 6-deoxy-β-D-galacto-heptopyranosides to 6-deoxy-β-D-ido-heptopyranosides is reported to obtain several oligosaccharides related to the capsular polysaccharides of C. jejuni HS:4.
This review summarises major contributions based on carbohydrate multivalent systems to study their interaction with human lectins.
Herein, total synthesis of a β-rhamnose containing ready-to-conjugate tetrasaccharide repeating unit related to the K141 CPS of A. baumannii KZ1106 using a [2 + 2] block glycosylation strategy has been demonstrated.
We have successfully developed an efficient approach for the first synthesis of gitonin from tigogenin. In a preliminary MTT bioassay, gitonin and structural analogues showed potent antiproliferative activities against A549, HepG2, and MCF-7 cell lines.