An operationally practical visible-light-driven heptafluoroisopropylation of diverse anilines and heterocyclic aromatics with the readily accessible heptafluoroisopropyl iodide (iC3F7-I) by an electron-donor–acceptor (EDA) strategy is presented.
A simple activation of perfluoroalkyl iodides by tBuONa or KOH allows the promotion of α-sp3 C–H amidation reactions of alkyl ethers and benzylic hydrocarbons, C–H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich π bonds.
This review summarizes the applications of late-stage strategies in the direct trifluoromethylation of natural products in the past ten years, with particular emphasis on the reaction model of each method.
This feature article highlights recent advances in leveraging the synthetic potential of α-diazo compounds for the development of novel and versatile chemical transformations.
We report a copper-mediated, visible-light-promoted cross-coupling of aryl thianthrenium salts with [(DMPU)2Zn(Rf)2] for modular site-selective perfluoroalkylation of arenes with tunable chain, expanding the post-perfluoroalkylation toolkit.