An SAR study of SP2509/SP2577 and TCP-based PROTACs targeting LSD1 revealed potent in vitro inhibitors, but no LSD1 degradation was observed in HCT116 cells.
Isolation of two new phenolic C-glucosides and in silico LSD1 and quorum sensing inhibitory potential of phytoconstituents isolated from Ardisia elliptica Thunb aerial parts.
A modular strategy is developed to construct diverse organelle-targeting fluorescent probes for selective imaging of formaldehyde in the nucleus, ER, mitochondria, and lysosomes of live cells.
2,5-Diazabicyclo[2.2.1]heptane (2,5-DBH) is a conformationally rigid bicyclic diamine and a privileged scaffold in medicinal chemistry, enabling diverse synthetic modifications and broad therapeutic applications across multiple disease areas.
Exploring the evolution of acridine hybrids as multi-targeted anticancer agents, this review synthesizes key SAR insights and design principles. It evaluates the impact of hybridization on potency, selectivity, and preclinical development.