This study addresses the longstanding challenge of meta constraint in the Catellani reaction by pioneering a directing group strategy for meta-substituted aryl iodides, enabling an atroposelective synthesis of axially chiral biaryls.
A redox-neutral C–H glycosylation method to access a diverse array of (hetero)aryl glycosides via palladium/norbornene (Pd/NBE) cooperative catalysis was disclosed.
Palladium-catalyzed bis-silylation/bis-germanylation of glycals enables modular synthesis of Si-/Ge-glycosides. Using ONBD as a switch and an ethylene surrogate gives (Z)-β-substituted vinylsilane/germane glycosides under mild conditions.
Transition-metal-catalyzed alkene-relayed intermolecular C–H activation reactions, which constitute a novel strategy for C–H functionalization, have been reviewed.
We report a Pd/NBE cooperative catalyzed ortho C–H methylation and trideuteromethylation of arylthianthrenium salts, enabling the efficient synthesis of a wide variety of (trideutero)methylated arenes in moderate to good yields.