Functionalized fluorenones/fluorenes are generally synthesized via cross-coupling reactions. Described here is the modification of the fluorene/fluorenone core via a C–H functionalization tactic and augmentation of the fluorenes/fluorenones library.
In the last decade numerous techniques have been developed in Pd-catalysed distal C–H activation ranging from template-assisted to the use of inherent functional groups as the directing auxiliary including ligand-enabled transformations.
The synthesis of dansylated (fluorescent) phenylalanine-type amino acid motifs via a C(sp3)–H arylation strategy and high-content screening against IAV infection to identify the antiviral properties of the synthesized molecules are reported.
Direct alteration of unactivated C–H bonds of organic building blocks.
Radical-mediated direct photoredox β-C(sp3)–H arylation of 1-(o-iodoaryl)alkan-1-ones with cyanoarenes directed by an iodoarene group is depicted.