Asmaa M. Atta, Nouran Rihan, Ahmad M. Abdelwaly, Mohamed S. Nafie, Mohamed S. Elgawish, Samia M. Moustafa, Mohamed A. Helal and Khaled M. Darwish
RSC Med. Chem., 2025,16, 2202-2230
Abstract
Drug-like molecules designed by fragment growing strategy on isocytosine and acyl guanidine warheads as BACE1 inhibition. In vivo characterization of top-active benzimidazoles (16a, 16k) showed Aβ/oxidation stress reduction and brain/liver safety.
Ahmad Elshahary, Hesham Safwan, Ahmad Abdelwaly, Reem K. Arafa and Mohamed A. Helal
RSC Med. Chem., 2026,17, 245-262
Abstract
mTOR inhibitors were designed based on indole and quinolone scaffolds. Sub-micromolar inhibition was achieved together with moderate cytotoxic activities.
Elizaveta I. Basanova, Ekaterina A. Kulikova, Nikolai I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Alyona S. Ovchinnikova, Dmitry A. Odnoshevskiy, Oleg V. Pyankov, Alexander P. Agafonov, Olga I. Yarovaya, Sophia S. Borisevich, Margarita G. Ilyina, Dmitry S. Kolybalov, Sergey G. Arkhipov, Nikita E. Bogdanov, Marina A. Pavlova, Nariman F. Salakhutdinov, Valery P. Perevalov and Polina A. Nikitina
RSC Med. Chem., 2024,15, 3196-3211
Abstract
Newly synthesized 2-aryl-1-hydroxyimidazoles display promising antiviral activity against orthopoxviruses, including the variola virus.
Samar S. Tawfik, Abdelrahman Hamdi, Ahmed R. Ali, Abdullah A. Elgazar, Hamed W. El-Shafey, Adel S. El-Azab, Ahmed H. Bakheit, Mohamed M. Hefnawy, Hazem A. Ghabbour and Alaa A.-M. Abdel-Aziz
RSC Adv., 2024,14, 26325-26339
Abstract
Novel quinazolin-4(3H)-ones 4–27 were synthesized. Compounds 4, 11, and 20 showed potential anti-tumour activities. 4, 11, and 20 blocked EGFR/VEGFR-2 and triggered apoptosis. Compound 4 showed the most potent activity against EGFR/VEGFR-2.
Yohei Yasuno, Atsushi Tarui, Shoki Hoshikawa, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai and Masaaki Omote
New J. Chem., 2025,49, 19489-19497
From themed collection:
Celebration of the 70th birthday of Prof. Giuseppe Resnati
Abstract
We report a concise and practical one-pot synthesis of 3-fluoroquinolines via a decarboxylative Mannich-type reaction of α,α-difluoro-β-ketoesters with N-aryl imines in the presence of Yb(OTf)3.