Anas Ramadan Kotb, Abdallah E. Abdallah, Hazem Elkady, Ibrahim H. Eissa, Mohammed S. Taghour, Dina Abed Bakhotmah, Tamer M. Abdelghany and Mohamed Ayman El-Zahabi
RSC Adv., 2023,13, 10488-10502
Abstract
Novel thalidomide analogs as anticancer immunomodulatory agents.
Yuka Amako, Saki Ichikawa, Hannah C. Lloyd, N. Connor Payne, Zhi Lin, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Qian Zhu, Bogdan Budnik, Ralph Mazitschek and Christina M. Woo
Chem. Sci., 2025,16, 11519-11529
Abstract
A systematic investigation of cyclic imide stereoisomers in small molecules, peptides, and proteins, examining their racemization, CRBN engagement, ternary complex formation in vitro, and resulting degradation outcomes in cells.
Wael Shehta, Basant Farag, Shaker Youssif, Samar El-Kalyoubi and Sherin M. Elfeky
RSC Adv., 2025,15, 36895-36906
Abstract
Two pyrimidine hybrid series (6a–g, 10a–d) were synthesized. Compounds 6c and 10b showed anti-proliferative activity against MCF-7, strong EGFR-TK inhibition, and docking confirmed effective binding. In silico studies suggest safe, orally bioavailable candidates.
Yahia A. Amin, Mohamed M. Khalifa, Wafa A. Bawazir, Ahd A. Mansour, Helmy Sakr, Mariam K. Alamoudi and Mohamed Ayman El-Zahabi
New J. Chem., 2025,49, 17168-17177
Abstract
A new series of naphthalimide derivatives were designed and synthesized to afford novel potent antitumor immunomodulatory thalidomide analogs.
Radosław P. Nowak, Jianwei Che, Silas Ferrao, Nikki R. Kong, Hu Liu, Breanna L. Zerfas and Lyn H. Jones
RSC Med. Chem., 2023,14, 501-506
Abstract
Ternary complex structural knowledge enabled elucidation of structure–degradation relationships that will assist the future design of cereblon modulators that avoid GSPT1 toxicity.