Jinghan Bu, Xuanwen Tao, Mengyi Huang, Zixin Chen, Tao Zhao and Qiang Yang
Chem. Commun., 2026,62, 98-111
Abstract
Difluorocarbene can function as a versatile fluorine and carbon source, engaging in unique reactions with amines to achieve important transformations, including fluorination. These reactions demonstrate its broad prospects for synthetic applications.
Kohei Fuchibe and Junji Ichikawa
Chem. Commun., 2023,59, 2532-2540
Abstract
Free and metal difluorocarbenes reacted with (thio)carbonyl compounds and silyl dienol ethers to provide difluoromethyl (thio)ethers, ring-fluorinated carbo/heterocycles and difluoroalkenes.
Wen-Jie Pan, Jiao Yu, Wei-Guo Cao, Ji-Chang Xiao and Jin-Hong Lin
Org. Chem. Front., 2024,11, 120-126
Abstract
Described herein is the use of difluorocarbene as a C–F source for the cyclization of 2-aminobenzenethiols to provide fluorinated benzothiazoles. A one-step process installs a fluorine atom and constructs a heterocycle.
Zhiyong Tan, Tingting Chen, Jiayi Shen, Jinbin Zhu, Weihong Zhong and Wei Guo
Org. Chem. Front., 2025,12, 3004-3010
Abstract
A novel carbonylative Suzuki–Miyaura reaction for the synthesis of diaryl ketones has been achieved via palladium-catalyzed difluorocarbene transfer. The reactive intermediate of PdII![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
CF2 could be controlled using a N,N,N-tridentate ligand.
Yingxian Tian, Yiyan Xiong, Jingyu Wei, Gongming Zhu, Junbiao Chang and Bingxian Liu
Chem. Sci., 2026, Advance Article
Abstract
An efficient difluorocarbene-mediated tandem strategy for the synthesis of 2-fluoroquinazolin-4(3H)-ones via a sequential single-atom-insertion process has been developed.