A Review of Polygonatum Mill. Genus: Its Taxonomy, Chemical Constituents, and Pharmacological Effect Due to Processing Changes

Lu Luo, Yixing Qiu, Limin Gong, Wei Wang and Ruiding Wen

Molecules, 2022, 27, 4821
DOI: 10.3390/molecules27154821

Investigation of the repairing effects and mechanisms of Polygonatum Odoratum polysaccharides on myofibrillar protein gelation under hydroxyl radical-induced oxidative stress

Xinying Wang, Rongsheng Du, Yuan Liu, Linlin Wang and Lina Wang

Food Chemistry: X, 2025, 28, 102573
DOI: 10.1016/j.fochx.2025.102573

Ultrasonic assisted three-phase partitioning extraction and bioactivities validation of polysaccharides from Flammulina velutipes residues

Yao Zhang, Changjiao Zhong, Shiyu Liu, Linna Du, Hongxia Ma, Haipeng Zhang, Yuting Li, Chengguang He and Lili Guan

Food Chemistry: X, 2025, 31, 103177
DOI: 10.1016/j.fochx.2025.103177

Harnessing the structural dynamics of fructans: decoding hydrothermal processing effects on functional polymeric carbohydrates

Huan Gong, Songshan Shi, Zexi Zhang, Xiaona Gan, Wenqi Song, Jie Chen, Paiziliya Paerhati, Tingzhao Li, Dong Liu, Bo Li, Shunchun Wang and Huijun Wang

Food Hydrocolloids, 2026, 175, 112501
DOI: 10.1016/j.foodhyd.2026.112501

Bioactive phytochemicals and associated multifunctional health-promoting effects of Polygonati Rhizoma

Shuzhen Wang, Feng He, Yunli Xiao, Fu Xiang, Lan Lu, Wei Wu, Chi-Tang Ho and Shiming Li

Food Science and Human Wellness, 2025, 14, 9250126
DOI: 10.26599/FSHW.2024.9250126

Research progress on extraction, processing technology and pharmacological action of Polygonatum polysaccharides: A review

Weiyi Zhao, Lingzhuo An, Hongyue Tian, Xia Li and Wenyuan Gao

International Journal of Biological Macromolecules, 2026, 352, 150808
DOI: 10.1016/j.ijbiomac.2026.150808

Identification of carbohydrate in Polygonatum kingianum Coll. et Hemsl and inhibiting oxidative stress

Junyuan Huang, Yanlan Chen, Yi Su, Wanqing Yuan, Dong Peng, Ziwen Guan, Jianping Chen, Pan Li and Bing Du

International Journal of Biological Macromolecules, 2024, 261, 129760
DOI: 10.1016/j.ijbiomac.2024.129760

Traditional Processing Can Enhance the Medicinal Effects of Polygonatum cyrtonema by Inducing Significant Chemical Changes in the Functional Components in Its Rhizomes

Jianjun Shen, Weiting Pu, Qiyan Song, Bihuan Ye, Xiaoxiao Shi, Youwu Chen, Yefei Yu and Haibo Li

Pharmaceuticals, 2024, 17, 1074
DOI: 10.3390/ph17081074

Discrimination of Polygonatum Species via Polysaccharide Fingerprinting: Integrating Their Chemometrics, Antioxidant Activity, and Potential as Functional Foods

Zhiguo Liu, Wei Zhang and Bin Wang

Foods, 2025, 14, 2385
DOI: 10.3390/foods14132385

Construction and application of multiple nucleotide polymorphism-based DNA fingerprinting for Polygonatum cyrtonema identification

Min Tang, Yuqing Long, Juan Zeng, Wei Xiang, Peng Huang, Gang Wang and Jianguo Zeng

Front. Plant Sci., 2026, 17
DOI: 10.3389/fpls.2026.1758042

Polygonatum sibiricum polysaccharides protect against knee osteoarthritis by inhibiting the TLR2/NF-κB signaling pathway in vivo and in vitro

Shida Kuang, Zhewen Liu, Lumei Liu, Xinying Fu, Wen Sheng, Zongren Hu, Chengxiong Lin, Qinghu He, Jisong Chen and Shuguang Gao

International Journal of Biological Macromolecules, 2024, 274, 133137
DOI: 10.1016/j.ijbiomac.2024.133137

Combined transcriptome and metabolome analysis reveal the chemical composition diversity and ferulate 5-hydroxylase mediated metabolite regulatory mechanism in Polygonatum

Rong Liu, Pingtao Wang, Pijian Lu, Ya Dai, Wang Wu, Yurui Chen and Xin Chen

Current Plant Biology, 2025, 43, 100527
DOI: 10.1016/j.cpb.2025.100527

Physicochemical characterization and hypoglycemic potential of a novel polysaccharide from Polygonatum sibiricum Red through PI3K/Akt mediated signaling pathway

Song-Zi Xie, Wang-Juan Zhang, Wang Liu, Jin-Bo Bai, Song-Ling Xie, Tongsheng Wang, Guo-Bing Xu and De-Ling Wu

Journal of Functional Foods, 2022, 93, 105080
DOI: 10.1016/j.jff.2022.105080

Transcriptome analysis of three medicinal plants of the genus Polygonatum: identification of genes involved in polysaccharide and steroidal saponins biosynthesis

Jimei Lu, Jinchen Yao, Jingzhe Pu, Duomei Wang, Junling Liu, Yazhong Zhang and Liangping Zha

Front. Plant Sci., 2023, 14
DOI: 10.3389/fpls.2023.1293411

Dynamic Variation of Secondary Metabolites from Polygonatum cyrtonema Hua Rhizomes During Repeated Steaming–Drying Processes

Shuzhen Wang, Feng He, Ruibin Hu, Xuchun Wan, Wei Wu, Lei Zhang, Chi-Tang Ho and Shiming Li

Molecules, 2025, 30, 1923
DOI: 10.3390/molecules30091923

Polysaccharides from steam‐processed Polygonatum cyrtonema Hua protect against d‐galactose‐induced oxidative damage in mice by activation of Nrf2/HO‐1 signaling

Huanhuan Teng, Yi Zhang, Chuanshan Jin, Tongsheng Wang, Shengzhuo Huang, Lei Li, Songzi Xie, Deling Wu and Fengqing Xu

J Sci Food Agric, 2023, 103, 779
DOI: 10.1002/jsfa.12189

Polygonati rhizoma polysaccharides relieve exercise-induced fatigue by regulating gut microbiota

Jing Xian, Quanlong Chen, Chen Zhang, Qi Huang, Lele Zhang, Jiaqi Ma, Yixuan Feng, Yixi Zhu, Ziye Su, Teng Peng, Wei Xie and Jinming Zhang

Journal of Functional Foods, 2023, 107, 105658
DOI: 10.1016/j.jff.2023.105658

A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods: antioxidant and bile acid-binding capacity

Qiaoyun Li, Zuman Dou, Qingfei Duan, Chun Chen, Ruihai Liu, Yueming Jiang, Bao Yang and Xiong Fu

Food Science and Human Wellness, 2024, 13, 494
DOI: 10.26599/FSHW.2022.9250043

Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma

Shi-Jie Bi, An-Lei Yuan, Zi-Jun Chen, Yue Ren, Kai-Yang Liu, Chao-Qun Liu, Zhen-Zhen Xu, Ze-Wen Wang and Yan-Ling Zhang

Journal of Asian Natural Products Research, 2025, 27, 368
DOI: 10.1080/10286020.2024.2390496

Geographical variations in Polygonatum polysaccharides and saponins biosynthesis in Polygonatum species

Zihao Li, Zixuan Hu, Yikang Zhao, Lin Yang, Huaxuan Tang and Jiaru Li

Industrial Crops and Products, 2025, 227, 120814
DOI: 10.1016/j.indcrop.2025.120814

Structural characterization and bioactivity evaluation of a soluble polysaccharide (PCHP-1A) from Polygonatum cyrtonema Hua: antioxidant and α-glucosidase inhibitory activities

Lunbin Xia, Cunwu Chen, Shaoshuai Bi, Yafei Zhang, Naidong Chen and Jing Feng

Chem. Biol. Technol. Agric., 2025, 12
DOI: 10.1186/s40538-025-00768-0

Polygonati Rhizoma with the homology of medicine and food: A review of ethnopharmacology, botany, phytochemistry, pharmacology and applications

Linxian Zhao, Chunyi Xu, Weiling Zhou, Yanyan Li, Yongmei Xie, Huiling Hu and Zhanguo Wang

Journal of Ethnopharmacology, 2023, 309, 116296
DOI: 10.1016/j.jep.2023.116296

Evolutionary research trends of polysaccharides from Polygonatum genus: A comprehensive review of its isolation, structure, health benefits, and applications

Yanjun Yang, Yufei Yang, Weilin Wang, Yukun Chang, Yiyang Zhu, Yue Cheng, Bing Yang, Xiaobin Jia and Liang Feng

International Journal of Biological Macromolecules, 2025, 306, 141566
DOI: 10.1016/j.ijbiomac.2025.141566

A novel polysaccharide in Polygonatum kingianum: structure elucidation, the activities of anti-inflammatory and the regulation of gut microbiota in vitro

Xiao Han, Xin-Xiu Ren, Dan-Yang Zhang, Qin-Feng Guo, Shi-Meng Li, Zhi-Long Xiu and Yue-Sheng Dong

Nat. Prod. Bioprospect., 2025, 15
DOI: 10.1007/s13659-025-00542-7

A methylation-assisted gas chromatography-mass spectrometry strategy for comprehensive monosaccharide profiling in Polygonatum polysaccharides: Overcoming limitations of conventional chromatographic techniques

Liang Xu, Jinjian Yao, Zhen Wang, Songzi Xie, Jinmei Ou and Bin Wang

Journal of Chromatography A, 2025, 1759, 466253
DOI: 10.1016/j.chroma.2025.466253

Extraction, purification, structural characterization, biological activity, structure-activity relationship, and applications of polysaccharides derived from Polygonatum sibiricum: A review

Jiasu Wu, Chang Tan, Hongye Li, Siya Wang, Xingkui Wang, Shan Wang, Chong Ning, Weixuan Li and Chongting Guo

Trends in Food Science & Technology, 2025, 161, 105038
DOI: 10.1016/j.tifs.2025.105038

Effect of ultrasonic degradation on the physicochemical characteristics, GLP-1 secretion, and antioxidant capacity of Polygonatum cyrtonema polysaccharide

Wang Liu, Ya-Min Qin, Jin-Yang Shi, De-Ling Wu, Chun-Yang Liu, Juan Liang and Song-Zi Xie

International Journal of Biological Macromolecules, 2024, 274, 133434
DOI: 10.1016/j.ijbiomac.2024.133434

Structural characterization and anti-inflammatory activity of a novel polysaccharide from Paeonia lactiflora Pall

Pei-Pei Li, Xiang-Ming Jiang, Jin-Yang Shi, Wei Zhang, Yang-Fei Ding, Song-Zi Xie and De-Ling Wu

Journal of Functional Foods, 2024, 120, 106392
DOI: 10.1016/j.jff.2024.106392

Analysis of codon usage patterns in complete plastomes of four medicinal Polygonatum species (Asparagaceae)

Naixing Shi, Yiwen Yuan, Renjie Huang and Guosong Wen

Front. Genet., 2024, 15
DOI: 10.3389/fgene.2024.1401013

Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways

Yan Liu, Jiayi Yang, Zhijian Guo, Qizhang Li, Lida Zhang, Lingxia Zhao and Xuanwei Zhou

Molecules, 2024, 29, 3408
DOI: 10.3390/molecules29143408

Preparation and structure characterization of a natural acetylated fructooligosaccharide from Polygonatum sibiricum and its alleviative effect on colitis by inhibiting NLRP3 pathway

Shengchen Ding, Jun Chen, Guangming Chen, Weiyi Tian, Junping Zheng, Haiming Hu, Lu Cao, Xiaowei Yao, Baifei Hu and Hongtao Liu

Journal of Functional Foods, 2024, 113, 106027
DOI: 10.1016/j.jff.2024.106027

Structural characterization and antioxidant activities of polysaccharides extracted from Polygonati rhizoma pomace

Yunke Bu, Bangfeng Yin, Zhichang Qiu, Lingyu Li, Bin Zhang, Zhenjia Zheng and Minmin Li

Food Chemistry: X, 2024, 23, 101778
DOI: 10.1016/j.fochx.2024.101778

Preparation, analysis, biological activity of Polygonati Rhizoma polysaccharides: A review

Yue Wang and Yuanzhong Wang

Journal of Molecular Structure, 2025, 1328, 141368
DOI: 10.1016/j.molstruc.2025.141368

Advances in Polygonatum sibiricum polysaccharides: Extraction, purification, structure, biosynthesis, and bioactivity

Dan Liu, Wei Tang, Chao Han and Shaoping Nie

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.1074671

The Molecular Mechanism of Polysaccharides from Polygonatum cyrtonema Hua in Improving Hyperuricemia by Regulating Key Targets of Uric Acid Metabolism in Mice

Shoucheng Pu, Jufang Gong, Meihao Sun, Zunhong Hu and Zhihua Wu

Foods, 2025, 14, 3396
DOI: 10.3390/foods14193396

Structural Characterization and Immunomodulatory Activity of Polysaccharides from Polygonatum sibiricum Prepared with Deep Eutectic Solvents

Jikun Meng, Chunbo Guan, Qiufeng Chen, Xiao Pang, Heqin Wang, Xinwen Cui, Ran Ye, Xiuqing Zhang and Seyed Mohammad Taghi Gharibzahedi

Journal of Food Quality, 2023, 2023, 1
DOI: 10.1155/2023/3147644

Potential of non-digestible polysaccharides as GLP-1 secretagogues: action mechanisms, structure-activity relationships and clinical applications

Zhen-Zi Shang, Hui-Yu Ye, Qiang-Ming Li, Xue-Qiang Zha and Jian-Ping Luo

Carbohydrate Polymers, 2025, 367, 124024
DOI: 10.1016/j.carbpol.2025.124024

Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides

Shuzhen Wang, Feng He, Hongmei Wu, Fu Xiang, Hongyan Zheng, Wei Wu and Shiming Li

Molecules, 2023, 28, 1350
DOI: 10.3390/molecules28031350

Immunomodulatory Activity of Polysaccharides Isolated from Saussurea salicifolia L. and Saussurea frolovii Ledeb

Igor A. Schepetkin, Marina G. Danilets, Anastasia A. Ligacheva, Evgenia S. Trofimova, Natalia S. Selivanova, Evgenii Yu. Sherstoboev, Sergei V. Krivoshchekov, Ekaterina I. Gulina, Konstantin S. Brazovskii, Liliya N. Kirpotina, Mark T. Quinn and Mikhail V. Belousov

Molecules, 2023, 28, 6655
DOI: 10.3390/molecules28186655

Review of studies on polysaccharides, lignins and small molecular compounds from three Polygonatum Mill. (Asparagaceae) spp. in crude and processed states

Qihong Zhang, Zouyue Yang and Weike Su

International Journal of Biological Macromolecules, 2024, 260, 129511
DOI: 10.1016/j.ijbiomac.2024.129511

Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response

Jin-Yang Shi, Yong-Jian Wang, Qian-Wen Bao, Ya-Min Qin, Pei-Pei Li, Qiao-Qiao Wu, Cheng-Kai Xia, De-Ling Wu and Song-Zi Xie

Carbohydrate Polymers, 2025, 356, 123387
DOI: 10.1016/j.carbpol.2025.123387