Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids

Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher and Jean-François Brière

Org. Biomol. Chem., 2024, 22, 2948
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Single and dual functionalization of proteins using site-specific nucleophilic carbon ligations

Qiang Peng, Berlin Zang, Tao Xiong, Chundong Huang, Ting Xu, Chong Zhang, Jun Ren, Fangling Ji and Lingyun Jia

Chem. Commun., 2022, 58, 6316
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Cp*Co(iii)-catalyzed C–H functionalization/spiroannulation for the synthesis of spiroindenes from 1,3-indandione and alkenes

Xuefeng Xu, Di Wang, Mengfan Chang, Yue Shi and Xu Zhang

Org. Chem. Front., 2023, 10, 1715
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Recent advances of asymmetric catalytic transformations of alkylidene Meldrum's acid derivatives

Hélène Beucher, Vincent Levacher, Sylvain Oudeyer and Jean-François Brière

Chem. Commun., 2025, 61, 6555
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Palladium-catalyzed ring-opening [5+2] annulation of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acids: rapid synthesis of 7-membered lactones

Fei Li, Xin Chen, Ben-Qing Huang, Hua-Dong Xu, Chi-Fan Zhu and Mei-Hua Shen

Chem. Commun., 2024, 60, 1774
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Green and modular synthesis of azepino[4,3,2-cd]indoles and diazepino[6,5,4-cd]indoles via hydride transfer-involved cascade cyclization in ethanol

Qian-Hao Zhuang, Xiao-Lin Wang, Wei Gao, Bin Qiu, Xiao-De An, Houchen Wang, Yao-Bin Shen and Jian Xiao

Org. Chem. Front., 2025, 12, 4808
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Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study

Syed Nasir Abbas Bukhari, Mohamed Abdelwahab Abdelgawad, Naveed Ahmed, Muhammad Wahab Amjad, Muhammad Ajaz Hussain, Mervat A. Elsherif, Hasan Ejaz, Nasser H. Alotaibi, Ignjat Filipović and Nenad Janković

Pharmaceuticals, 2023, 16, 281
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Exploring the Bioactive Potential of 2,2‐Dimethyl‐1,3‐Dioxane‐4,6‐Dione: A Comprehensive Computational Analysis

Sheikh Alima, Md Saiful Danish, Sidrat, Md Arman, Fatima Khan, Shakeel Alvi, Mohammed Aljohani, Nazia Siddiqui and Saleem Javed

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202503092

A mild and atom-efficient four-component cascade strategy for the construction of biologically relevant 4-hydroxyquinolin-2(1H)-one derivatives

Dmitrii A Grishin, Kseniia I Sharkovskaia, Ilya G Kolmakov, Daria A Ipatova, Rostislav A Petrov, Nikolai D Dagaev, Dmitry A Skvortsov, Maria G Khrenova, Valeriy V Andreychev, Sergei A Evteev, Yan A Ivanenkov, Roman L Antipin, Olga А Dontsova and Elena K Beloglazkina

Beilstein J. Org. Chem., 2026, 22, 244
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Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies

Satya Kumar Avula, Saeed Ullah, Amirhossein Ebrahimi, Ali Rostami, Sobia Ahsan Halim, Ajmal Khan, Muhammad U. Anwar, Simon Gibbons, René Csuk and Ahmed Al-Harrasi

European Journal of Medicinal Chemistry, 2025, 283, 117174
DOI: 10.1016/j.ejmech.2024.117174

In-depth investigation of corrosion inhibition mechanism: Computational, electrochemical, and theoretical studies of vanillin meldrum’s acid on mild steel surface in 1 M HCl

Nur Aiman Najwa Kamarul Baharin, Sheikh Ahmad Izaddin Sheikh Mohd Ghazali, Siti Syaida Sirat, Amalina Mohd Tajuddin, Noor Hidayah Pungot, Erna Normaya, Siti Radiah Mohd Kamarudin and Nur Nadia Dzulkifli

Journal of Molecular Liquids, 2024, 416, 126390
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Substrate-Controlled Divergent Syntheses of Polycyclic Tetrahydropyrimidin-4-ones and 1,3-Oxazinane-4,6-diones from Dihydroisoquinolines and Meldrum’s Acid

Mahilyesan Hoole, Zhiqiang Long, Augustin Deboës, Gabriel Goujon, Charles Romain and Benjamin Laroche

J. Org. Chem., 2025, 90, 11237
DOI: 10.1021/acs.joc.5c01173

Synthesis, structural and biological studies of Cu(II) complex of a pH sensitive hydrazone, 5-(2-(2-hydroxyphenyl)hydrazono)-2,2-dimethyl-4,6-dione

Shubha S. Kumar, V. Sadasivan, S. Mini, R.S. Sreepriya and S. Biju

Inorganica Chimica Acta, 2025, 588, 122864
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Synthesis of 1,3‐oxazepine derivatives via tandem reaction of 5‐benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

Furgan Aslanoglu

Journal of Heterocyclic Chem, 2024, 61, 1364
DOI: 10.1002/jhet.4860

Multicomponent reactions with Meldrum's acid and isocyanides as a valuable synthetic approach: An update

Hadi Hassani Ardeshiri, Golnoosh Ghafari Tirabadi and Ahmad Shaabani

Mol Divers, 2026
DOI: 10.1007/s11030-026-11469-7

Regio- and Stereoselective Electro-Mediated Carboalkoxylation of 1,3-Dienes

Ophélie Montiège, Marion Siccardi, Morgane Sanselme, Cédric Schneider, Jean-François Brière and Hélène Beucher

Org. Lett., 2024, 26, 11105
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Accessing Diverse Polymer Architectures through Meldrum’s Acid-Functionalized Polysiloxane Precursors

Analise C. H. Migliaccio, Noel C. J. Migliaccio, Nathan J. Weeks and Scott T. Iacono

Macromolecules, 2026, 59, 3082
DOI: 10.1021/acs.macromol.5c03430

Reduktive Kohlenstoffmaterialien: Einstellung der chemischen und elektronischen Eigenschaften zur Verbesserung von Natrium‐Ionen‐Batterien

Elif Begüm Yılmaz, Enis Oğuzhan Eren, Tim Horner, Zihan Song, Yasaman Sheidaei, Inke Siewert, Evgeny Senokos and Paolo Giusto

Angewandte Chemie, 2025, 137
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Synthesis of Methyl 3-Hydroxyisoxazole-5-Carboxylate Via Bromination of Dimethyl Fumarate under Photoflow Conditions and Its Safe Homologation into 3-(3-Methoxyisoxazol-5-yl) Propanoic Acid

Cédric Bürki, Marco Künzli, Patric Dörrwächter, Patrick Wallquist-Franke, Larry Y. Wang, Feng Zhang and Gabriel Schäfer

Org. Process Res. Dev., 2024, 28, 1690
DOI: 10.1021/acs.oprd.3c00334

Disubstituted Meldrum’s Acid: Another Scaffold with SuFEx-like Reactivity

Baoqi Chen, Zhenguo Wang, Xiaole Peng, Jijun Xie, Zhixiu Sun and Le Li

Molecules, 2025, 30, 3534
DOI: 10.3390/molecules30173534

Synthesis of functionalized γ-lactams by a lewis acid catalyzed ketene formation/cyclization/claisen rearrangement sequence of 5,5-disubstituted Meldrum’s acid

Xiao-Wan Lin, Mei Han, Mei-Hua Shen, Chi-Fan Zhu and Hua-Dong Xu

Tetrahedron Letters, 2022, 99, 153816
DOI: 10.1016/j.tetlet.2022.153816

Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones

Julien Annibaletto, Thomas Martzel, Vincent Levacher, Sylvain Oudeyer and Jean‐François Brière

Adv Synth Catal, 2021, 363, 4447
DOI: 10.1002/adsc.202100719

Palladium-catalyzed [4 + 2] cycloaddition of 2-methylidenetrimethylene carbonate with C5-substituted Meldrum's acids: Rapid access to δ-lactones

Chi-Fan Zhu, Xiao-Jing Li, Hao-Ke Chu, Dong Jiang, Bo Tang, Ben-Qing Huang and Jing Xu

Tetrahedron Letters, 2025, 170, 155768
DOI: 10.1016/j.tetlet.2025.155768

4,5-Dihydro-2H-pyridazin-3-ones as a Platform for the Construction of Chiral 4,4-Disubstituted-dihydropyridazin-3-ones

Paul Joël Henry, Gabriel Burel, William Nzegge, Mario Waser and Jean-François Brière

Molecules, 2025, 31, 83
DOI: 10.3390/molecules31010083

Synthesis, Anti‐enzymatic Appraisal, In Silico, and SAR Analysis of 5‐Aryl/Heteroaryl‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione Derivatives

Saira Khatoon, Aamer Saeed, Syeda Aaliya Shehzadi, Haroon Mehfooz, Saima Kalsoom, Pervaiz Ali Channar, Hammad Ismail, Abdul Rauf, Sana Naveed, Parham Taslimi and Hesham El‐Seedi

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202404787

Predicting decomposition temperatures and carbonization feasibility of heterocycles with their decomposition mechanism

Pitambar Poudel, Sarah L. Masters and Aaron T. Marshall

Computational and Theoretical Chemistry, 2024, 1238, 114749
DOI: 10.1016/j.comptc.2024.114749

Modular access to chiral cyclopentanes via formal [2+2+1] annulation enabled by palladium/chiral squaramide relay catalysis

Lian-Feng Fan, Rui Liu, Pu-Sheng Wang and Liu-Zhu Gong

Tetrahedron Chem, 2022, 1, 100002
DOI: 10.1016/j.tchem.2021.100002

Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme‐Responsive “Covalent‐Assembly” Fluorescent Probes with Tailor‐Made Properties**

Kévin Renault, Yoan Capello, Shun Yao, Sami Halila and Anthony Romieu

Chemistry An Asian Journal, 2023, 18
DOI: 10.1002/asia.202300258

Alkylidene Meldrum′s Acid as Acceptor‐Donor‐Acceptor with Azomethine Ylide for Organocatalytic Asymmetric (3+2) Cycloaddition/Annulation: Synthesis of Chromeno[4,3‐b]pyrrolidine

Yan‐Cheng Liou, Yi‐Ru Chen, Ching‐Wen Hsu, Xuan‐Rui Huang, Heng‐Wei Wang and Wenwei Lin

Adv Synth Catal, 2023, 365, 3603
DOI: 10.1002/adsc.202300609

Access to Pyrazolo[1,5-a]pyrimidinone Regioisomers from Acylated Meldrum’s Acids

Maxime Donzel and Erik Chorell

Org. Lett., 2026, 28, 157
DOI: 10.1021/acs.orglett.5c04435

An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans

Pierre Milbeo, Arthur Lebrêne, Mariia Savchuk, Giang Vo‐Thanh, Sylvain Oudeyer, Hélène Beucher and Jean‐François Brière

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301311

Recent Developments in the Synthesis of β-Diketones

Gonzalo de Gonzalo and Andrés R. Alcántara

Pharmaceuticals, 2021, 14, 1043
DOI: 10.3390/ph14101043

Synthesis of Vanillic Acid—Meldrum’s Acid Conjugate

Laima Bērziņa and Inese Mieriņa

Molbank, 2025, 2025, M2005
DOI: 10.3390/M2005

Facile and Sustainable Synthesis of Commendamide and its Analogues

Rosaria Villano, Francesco Tinto and Vincenzo Di Marzo

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.858854

Hidden Reactivity of Barbituric and Meldrum’s Acids: Atom-Efficient Free-Radical C–O Coupling with N-Hydroxy Compounds

Igor B. Krylov, Stanislav A. Paveliev, Alexander S. Budnikov, Oleg O. Segida, Valentina M. Merkulova, Vera A. Vil’, Gennady I. Nikishin and Alexander O. Terent’ev

Synthesis, 2022, 54, 506
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Design of Synthetic Strategies towards Sulfur Containing Scaffolds

Sambasivarao Kotha and Priti Khedkar

Synthesis, 2025, 57, 275
DOI: 10.1055/s-0043-1775393

A One-Pot Two-Step Three-Component Stereoselective Mechanosynthesis of Ester-Functionalized Multisubstituted Δ2-Pyrazolines and Their Application in the Detection of Fluoride Ions

Amirhossein Ebrahimi, Negin Fattahi Ghahnavieh, Muhammad Usman Anwar, Ahmed Al-Harrasi and Ali Rostami

ACS Sustainable Chem. Eng., 2024, 12, 13750
DOI: 10.1021/acssuschemeng.4c01790

One‐pot Modular Synthesis of Hydroquinolines, Hydrofluorenones, and Aryl Fluorenones

Nandini Ray, Santanu Ghosh, Kaushik Soni, Kalishankar Bhattacharyya and Chandan K. Jana

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202502912

Design, Synthesis, and Biological Activity of Guaiazulene Derivatives

Zongchen Ma, Xiao Han, Junde Ren, Kun Liu, Wenjie Zhang and Guoqiang Li

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202201174

Crystal Structure, Photophysical Study, Hirshfeld Surface Analysis, and Nonlinear Optical Properties of a New Hydroxyphenylamino Meldrum’s Acid Derivative

Wulan Zeng, Xia Wang, Tao Zhou and Yunju Zhang

Molecules, 2023, 28, 2181
DOI: 10.3390/molecules28052181

The Molecular Diversity Scope of Meldrum's Acid in Multicomponent Reactions

Ghodsi Mohammadi Ziarani, Dorsa Ebrahimi, Fatemeh Mohajer, Rajender S. Varma and Siavash Iravani

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202302152

Tailored Silica‐Based Sensors (SBA‐Pr‐Ald‐MA) for Efficient Detection of Iron (III) Ions: A Comprehensive Theoretical and Experimental Viewpoint

Ghodsi Mohammadi Ziarani, Dorsa Ebrahimi, Mehran Feizi‐Dehnayebi, Alireza Badiei and Ahmed M. Abu‐Dief

Applied Organom Chemis, 2025, 39
DOI: 10.1002/aoc.7917

Novel octapeptide containing the RGD sequence as a potential anti-SARS-CoV-2 agent: design, synthesis, and theoretical studies

Reiner Lemos, Orlando Ortiz, Luis Almagro, Kamil Makowski, Hortensia Rodríguez, Fernando Albericio and Margarita Suarez

Amino Acids, 2025, 57
DOI: 10.1007/s00726-025-03480-3

Reductive Carbon Materials: Tailoring Chemistry and Electronic Properties to Improve Sodium‐Ion Batteries

Elif Begüm Yılmaz, Enis Oğuzhan Eren, Tim Horner, Zihan Song, Yasaman Sheidaei, Inke Siewert, Evgeny Senokos and Paolo Giusto

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202422714