Theoretical study on substrate recognition and catalytic mechanisms of gephyronic acid dehydratase DH1

Lei Liu, Qian Yu, Haoqing Zhang, Wentao Tao, Rufan Wang, Linquan Bai, Yi-Lei Zhao and Ting Shi

Catal. Sci. Technol., 2021, 11, 2155
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Mechanistic insights into double-bond migration mediated by bifunctional dehydratases in ansamitocin biosynthesis

Yingzhe Guo, Jiaxi Guo, Zeqian Du and Ting Shi

Catal. Sci. Technol., 2026
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Information-Rich, Dual-Function 13C/2H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition

Stephany M. Ramos de Dios, Jared L. Hass, Danielle L. Graham, Nivesh Kumar, Aina E. Antony, Martha D. Morton and David B. Berkowitz

J. Am. Chem. Soc., 2023, 145, 3158
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Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases

Erin E. Drufva, Elijah G. Hix and Constance B. Bailey

Synthetic and Systems Biotechnology, 2020, 5, 62
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Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Jesus F Barajas, Ryan P McAndrew, Mitchell G Thompson, Tyler W H Backman, Bo Pang, Tristan de Rond, Jose H Pereira, Veronica T Benites, Héctor García Martín, Edward E K Baidoo, Nathan J Hillson, Paul D Adams and Jay D Keasling

Journal of Industrial Microbiology and Biotechnology, 2019, 46, 1225
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Strategies for tailoring pH performances of glycoside hydrolases

Shu-Fang Li, Feng Cheng, Ya-Jun Wang and Yu-Guo Zheng

Critical Reviews in Biotechnology, 2023, 43, 121
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A Unified Mechanism Reveals the Evolutionary Origin of Enoyl Isomerases

Bing Chen, Jinwei Ren, Huimin Zhao and Bin Wang

ACS Catal., 2025, 15, 15649
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AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

Hong Jie Zhu, Bo Zhang, Wanqing Wei, Shuang He Liu, Lang Xiang, Jiapeng Zhu, Rui Hua Jiao, Yasuhiro Igarashi, Ghader Bashiri, Yong Liang, Ren Xiang Tan and Hui Ming Ge

Nat Commun, 2022, 13
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Stereochemische Entschlüsselung der Strobilurin‐PKS enthüllt die komplexe biosynthetische Logik des iterativen Aufbaus eines EZE‐Triens

Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao and Russell J. Cox

Angewandte Chemie, 2026, 138
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Effects of Lysinibacillus sphaericus HY3 on the gut microbiota, metabolism and resistance to Aeromonas hydrophila infection of adult zebrafish (Danio rerio)

Haoyu Qiu, Yuting Zhu, Hanying Wang, Chenzhi Tao, Zhiqiang Ran, Jiahang Xu, Junbo Wang, Shiyong Huang and Ping Wang

Aquaculture Reports, 2025, 42, 102815
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Structural insights into modular polyketide synthases: From individual domains to supramolecular assemblies

Minjae Kim, Hyeongwoo Kim and Jin Young Kang

Bulletin Korean Chem Soc, 2025, 46, 1048
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Animal Fatty Acid Synthase: A Chemical Nanofactory

Pedro Paiva, Fabiola E. Medina, Matilde Viegas, Pedro Ferreira, Rui P. P. Neves, João P. M. Sousa, Maria J. Ramos and Pedro A. Fernandes

Chem. Rev., 2021, 121, 9502
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Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference

Andreas Dietl, Kathrin Wellach, Pavithra Mahadevan, Nicole Mertes, Sophie L. Winter, Tobias Kutsch, Carlo Walz, Ilme Schlichting, Sebastian Fabritz and Thomas R.M. Barends

Journal of Biological Chemistry, 2023, 299, 104602
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How cis-Acyltransferase Assembly-Line Ketosynthases Gatekeep for Processed Polyketide Intermediates

Melissa Hirsch, Brendan J. Fitzgerald and Adrian T. Keatinge-Clay

ACS Chem. Biol., 2021, 16, 2515
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Stereochemical Dissection of the Strobilurin PKS Reveals the Complex Biosynthetic Logic of Iterative EZE Triene Construction

Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao and Russell J. Cox

Angew Chem Int Ed, 2026, 65
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Diene incorporation by a dehydratase domain variant in modular polyketide synthases

Christian Hobson, Matthew Jenner, Xinyun Jian, Daniel Griffiths, Douglas M. Roberts, Matias Rey-Carrizo and Gregory L. Challis

Nat Chem Biol, 2022, 18, 1410
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Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

Daisuke Kawasaki, Akimasa Miyanaga, Taichi Chisuga, Fumitaka Kudo and Tadashi Eguchi

Biochemistry, 2019, 58, 4799
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Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli

Greg J. Dodge, Ashay Patel, Kara L. Jaremko, J. Andrew McCammon, Janet L. Smith and Michael D. Burkart

Proc. Natl. Acad. Sci. U.S.A., 2019, 116, 6775
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Theoretical Studies on the Catalytic Mechanism and Cyclization Pattern of Fungal Polyketide Synthase Product Template Domain

Huining Ji, Ting Shi, Yi‐Lei Zhao and Jianting Zheng

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202400800