Inhibition of the NorA efflux pump of Staphylococcus aureus by synthetic riparins

L.M. Costa, E.V. de Macedo, F.A.A. Oliveira, J.H.L. Ferreira, S.J.C. Gutierrez, W.J. Peláez, F.C.A. Lima, J.P. de Siqueira Júnior, H.D.M. Coutinho, G.W. Kaatz, R.M. de Freitas and H.M. Barreto

J Appl Microbiol, 2016, 121, 1312
DOI: 10.1111/jam.13258

Efflux pump inhibitors for bacterial pathogens

Atin Sharma, Vivek Kumar Gupta and Ranjana Pathania

Indian Journal of Medical Research, 2019, 149, 129
DOI: 10.4103/ijmr.IJMR_2079_17

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

Mariana Matias, Ana Fortuna, Joana Bicker, Samuel Silvestre, Amílcar Falcão and Gilberto Alves

European Journal of Pharmaceutical Sciences, 2017, 109, 334
DOI: 10.1016/j.ejps.2017.08.023

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

S.W.C. Silva, N.B.N. Monção, B.Q. Araújo, D.D.R. Arcanjo, J.H.L. Ferreira, J.S. Lima Neto, A.M.G.L. Citó, J.P. de Siqueira Júnior, G.W. Kaatz and H.M. Barreto

Lett Appl Microbiol, 2019
DOI: 10.1111/lam.13163

Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms

Domenico Schillaci, Virginia Spanò, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Paola Barraja, Patrizia Diana, Girolamo Cirrincione and Stella Cascioferro

J. Med. Chem., 2017, 60, 8268
DOI: 10.1021/acs.jmedchem.7b00215

Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Huan Xiao, Yongcheng Zheng, Lingling Ma, Lili Tian and Qiu Sun

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.648407

Modulatory Effect of Croton heliotropiifolius Kunth Ethanolic Extract on Norfloxacin Resistance in Staphylococcus aureus

Samara Barbosa de Brito, Felipe Araújo de Oliveira Alcântara, Antonio Linkoln Alves Borges Leal, Kaliny Henri da Silva Veloso, Leonardo da Rocha Sousa, Ana Paula de Oliveira, Alan Diego da Conceição Santos, Lívia Macedo Dutra, Jackson Roberto Guedes da Silva Almeida, Carlos Emídio Sampaio Nogueira, João Sammy Nery de Souza, Natália Cruz-Martins, Daniel Dias Rufino Arcanjo and Humberto Medeiros Barreto

DDC, 2023, 3, 1
DOI: 10.3390/ddc3010001

Progress on synthesis and structure-activity relationships of lamellarins over the past decade

Mingze Wei, Jing Chen, Yuliang Song, Jean-Philippe Monserrat, Yongmin Zhang and Li Shen

European Journal of Medicinal Chemistry, 2024, 269, 116294
DOI: 10.1016/j.ejmech.2024.116294

Inhibition of the NorA multi-drug transporter by oxygenated monoterpenes

Mayara Ladeira Coêlho, Josie Haydée Lima Ferreira, José Pinto de Siqueira Júnior, Glenn W. Kaatz, Humberto Medeiros Barreto and Ana Amélia de Carvalho Melo Cavalcante

Microbial Pathogenesis, 2016, 99, 173
DOI: 10.1016/j.micpath.2016.08.026

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

Gautam Kumar and Asha Kiran Tudu

Bioorganic & Medicinal Chemistry, 2023, 80, 117187
DOI: 10.1016/j.bmc.2023.117187

Identification of Compounds With Potential Dual Inhibitory Activity Against Drug Efflux Pumps in Resistant Cancer Cells and Bacteria: Protocol for a Systematic Review

Elina Beleva, Antonia Diukendjieva, Ilza Pajeva and Ivanka Tsakovska

JMIR Res Protoc, 2025, 14, e66197
DOI: 10.2196/66197

Reining in Multidrug Resistance Protein 1 via Binding Its Flexible Interdomain Linker with Sequence-Selective Peptide-Binding Nanoparticles

Avijit Ghosh, Mansi Sharma and Yan Zhao

Biomacromolecules, 2026, 27, 2223
DOI: 10.1021/acs.biomac.5c02567

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

Jinyun Dong, Zuodong Qin, Wei-Dong Zhang, Gang Cheng, Assaraf G. Yehuda, Charles R. Ashby, Zhe-Sheng Chen, Xiang-Dong Cheng and Jiang-Jiang Qin

Drug Resistance Updates, 2020, 49, 100681
DOI: 10.1016/j.drup.2020.100681

Piperine analog PGP-41 treatment overcomes paclitaxel resistance in NCI/ADR-RES ovarian cells by inhibition of MDR1

Sadhana Sharma, Sushil Choudhary, Sukhleen Kaur, M. Venkat Reddy, Niranjan Thota, Amarinder Singh, Surrinder Koul, Inshad Ali Khan, Zabeer Ahmed and Ajay Kumar

Chemico-Biological Interactions, 2023, 381, 110569
DOI: 10.1016/j.cbi.2023.110569

An Update on Staphylococcus aureus NorA Efflux Pump Inhibitors

Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino and Francisco Jaime B. Mendonça Junior

CTMC, 2020, 20, 2168
DOI: 10.2174/1568026620666200704135837

Plant derived inhibitors of bacterial efflux pumps: an update

Sandra Prasch and Franz Bucar

Phytochem Rev, 2015, 14, 961
DOI: 10.1007/s11101-015-9436-y

Ciprofloxacin Enhances the Chemosensitivity of Cancer Cells to ABCB1 Substrates

Pranav Gupta, Hai-Ling Gao, Yunali V. Ashar, Nishant M. Karadkhelkar, Sabesan Yoganathan and Zhe-Sheng Chen

IJMS, 2019, 20, 268
DOI: 10.3390/ijms20020268

Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria

Kadja Luana Chagas Monteiro, Osmar Nascimento Silva, Igor José dos Santos Nascimento, Francisco Jaime Bezerra Mendonça Júnior, Pedro Gregório Vieira Aquino, Edeildo Ferreira da Silva-Júnior and Thiago Mendonça de Aquino

CTMC, 2022, 22, 1983
DOI: 10.2174/1568026622666220321124452

Tetrahydropyrrolization of Resveratrol and Other Stilbenes Improves Inhibitory Effects on DNA Oxidation

Liang‐Liang Bao and Zai‐Qun Liu

ChemMedChem, 2016, 11, 1617
DOI: 10.1002/cmdc.201600205

One-pot multicomponent synthesis of 1,2,3,4-tetrasubstituted pyrroles catalyzed by [NMPH]CH3SO3

Luana A. Pachechne, Vinicius F. Pereira, Guilherme M. Martins, Edmar Martendal, Fernando R. Xavier and Samuel R. Mendes

Tetrahedron Letters, 2019, 60, 151043
DOI: 10.1016/j.tetlet.2019.151043

Antifungal Azoles as Tetracycline Resistance Modifiers in Staphylococcus aureus

Nisha Mahey, Rushikesh Tambat, Dipesh Kumar Verma, Nishtha Chandal, Krishan Gopal Thakur, Hemraj Nandanwar and Christopher A. Elkins

Appl Environ Microbiol, 2021, 87
DOI: 10.1128/AEM.00155-21

Nanocarrier-based co-delivery approaches of chemotherapeutics with natural P-glycoprotein inhibitors in the improvement of multidrug resistance cancer therapy

Shadab Md, Nabil A. Alhakamy, Priyanka Sharma, Mohammad Shahnawaze Ansari and Bapi Gorain

Journal of Drug Targeting, 2022, 30, 801
DOI: 10.1080/1061186X.2022.2069782

Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates

Aya A. Mahfouz, Heba S. Said, Sherin M. Elfeky and Mona I. Shaaban

Antibiotics, 2023, 12, 503
DOI: 10.3390/antibiotics12030503

New Is Old, and Old Is New: Recent Advances in Antibiotic-Based, Antibiotic-Free and Ethnomedical Treatments against Methicillin-Resistant Staphylococcus aureus Wound Infections

Jian-Lin Dou, Yi-Wei Jiang, Jun-Qiu Xie and Xiao-Gang Zhang

IJMS, 2016, 17, 617
DOI: 10.3390/ijms17050617

Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)

Hang Zhang, Haiwei Xu, Charles R. Ashby, Yehuda G. Assaraf, Zhe‐Sheng Chen and Hong‐Min Liu

Medicinal Research Reviews, 2021, 41, 525
DOI: 10.1002/med.21739

Modulation of antimicrobial efflux pumps of the major facilitator superfamily in Staphylococcus aureus

Manjusha Lekshmi, Parvathi Ammini, Jones Adjei, Leslie M. Sanford, Ugina Shrestha, Sanath Kumar and Manuel F. Varela

AIMS Microbiology, 2018, 4, 1
DOI: 10.3934/microbiol.2018.1.1

Synthesis and Neuroprotective Activity of Neolamellarin A Analogues

Meng Zhang, Ruijuan Yin, Yiran Zhang, Cui Hao, Lijuan Zhang and Tao Jiang

J. Ocean Univ. China, 2018, 17, 967
DOI: 10.1007/s11802-018-3530-x

Pharmacophore modeling and 3D-QSAR studies of galloyl benzamides as potent P-gp inhibitors

Shubham Srivastava, Bhanwar Singh Choudhary, Manish Sharma and Ruchi Malik

Med Chem Res, 2016, 25, 1140
DOI: 10.1007/s00044-016-1556-4

Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria

Samsher Singh, Nitin P. Kalia, Prashant Joshi, Ajay Kumar, Parduman R. Sharma, Ashok Kumar, Sandip B. Bharate and Inshad A. Khan

Front. Microbiol., 2017, 8
DOI: 10.3389/fmicb.2017.01868

Photosensitizer associated with efflux pump inhibitors as a strategy for photodynamic therapy against bacterial resistance

Ieda Vieira da Cunha, Douglas Davison da Silva Oliveira, Gabriel Guimarães Calefi, Nagela Bernadelli Sousa Silva, Carlos Henrique Gomes Martins, Celso de Oliveira Rezende Júnior and Tayana Mazin Tsubone

European Journal of Medicinal Chemistry, 2025, 284, 117197
DOI: 10.1016/j.ejmech.2024.117197