Two-way communication betweenex vivotissues on a microfluidic chip: application to tumor–lymph node interaction

Sangjo Shim, Maura C. Belanger, Alexandra R. Harris, Jennifer M. Munson and Rebecca R. Pompano

Lab Chip, 2019, 19, 1013
DOI: 10.1039/C8LC00957K

Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism

Jose M. Ayuso, Shreyans Sadangi, Marcos Lares, Shujah Rehman, Mouhita Humayun, Kathryn M. Denecke, Melissa C. Skala, David J. Beebe and Vijayasaradhi Setaluri

Lab Chip, 2021, 21, 1139
DOI: 10.1039/D0LC00988A

Micro, soft, windows: integrating super-resolution viewing capabilities into soft lithographic devices

Christopher Moraes

Integr. Biol., 2015, 7, 10
DOI: 10.1039/C4IB90046D

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

R. Portillo-Lara and N. Annabi

Lab Chip, 2016, 16, 4063
DOI: 10.1039/C6LC00718J

Self-assembled and perfusable microvasculature-on-chip for modeling leukocyte trafficking

Elisabeth Hirth, Wuji Cao, Marina Peltonen, Edo Kapetanovic, Claudius Dietsche, Sara Svanberg, Maria Filippova, Sai Reddy and Petra S. Dittrich

Lab Chip, 2024, 24, 292
DOI: 10.1039/D3LC00719G

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis

Jihoon Ko, Jungho Ahn, Suryong Kim, Younggyun Lee, Jungseub Lee, Dohyun Park and Noo Li Jeon

Lab Chip, 2019, 19, 2822
DOI: 10.1039/C9LC00140A

Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model

Lilu Liu, Zhaorong Xie, Wenyuan Zhang, Shimeng Fang, Jing Kong, Dong Jin, Jiao Li, Xiaojie Li, Xuesong Yang, Yong Luo, Bingcheng Lin and Tingjiao Liu

RSC Adv., 2016, 6, 35248
DOI: 10.1039/C6RA05645H

Analyzing angiogenesis on a chip using deep learning-based image processing

Dong-Hee Choi, Hui-Wen Liu, Yong Hun Jung, Jinchul Ahn, Jin-A Kim, Dongwoo Oh, Yeju Jeong, Minseop Kim, Hongjin Yoon, Byengkyu Kang, Eunsol Hong, Euijeong Song and Seok Chung

Lab Chip, 2023, 23, 475
DOI: 10.1039/D2LC00983H

Flow-induced stress on adherent cells in microfluidic devices

Jonathan Shemesh, Iman Jalilian, Anthony Shi, Guan Heng Yeoh, Melissa L. Knothe Tate and Majid Ebrahimi Warkiani

Lab Chip, 2015, 15, 4114
DOI: 10.1039/C5LC00633C

Engineering perfusion to meet tumor biology: are vascularized tumor-on-a-chip models ready to drive therapy innovation?

Ines Poljak, Ciro Chiappini and Giulia Adriani

Lab Chip, 2026, 26, 1162
DOI: 10.1039/D5LC01060H

Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills

Lailai Li, Ningning Liu, Xiangdong Dai, Haifeng Yan, Ling Zhang, Leilei Xing, Yi Wang and Yi Wang

RSC Adv., 2016, 6, 115308
DOI: 10.1039/C6RA19212B

Applications of tumor chip technology

Stephanie J. Hachey and Christopher C. W. Hughes

Lab Chip, 2018, 18, 2893
DOI: 10.1039/C8LC00330K

Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

Menglin Shang, Ren Hao Soon, Chwee Teck Lim, Bee Luan Khoo and Jongyoon Han

Lab Chip, 2019, 19, 369
DOI: 10.1039/C8LC00970H

Establishment and application of a dynamic tumor-vessel microsystem for studying different stages of tumor metastasis and evaluating anti-tumor drugs

Bolin Jing, Yong Luo, Bingcheng Lin, Jianjun Li, Zhuo A. Wang and Yuguang Du

RSC Adv., 2019, 9, 17137
DOI: 10.1039/C9RA02069A

A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis

Didem Rodoplu, Jefunnie Sierra Matahum and Chia-Hsien Hsu

Lab Chip, 2022, 22, 1275
DOI: 10.1039/D1LC01177D

Self-assembled human arteriole-on-a-chip for arterial functionality testing and disease modeling

Subhashree Shivani, Hsin-Jou Wang, Yi-Ting Chen, Chih-Ting Lin and Yu-Hsiang Hsu

Lab Chip, 2025, 25, 5162
DOI: 10.1039/D5LC00530B

Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making

Ashlyn T. Young, Kristina R. Rivera, Patrick D. Erb and Michael A. Daniele

ACS Sens., 2019, 4, 1454
DOI: 10.1021/acssensors.8b01549

Three dimensional (bio)printing of blood vessels: from vascularized tissues to functional arteries

Shubham Makode, Satyajit Maurya, Seyed A Niknam, Evelyn Mollocana-Lara, Kiana Jaberi, Negar Faramarzi, Ali Tamayol and Mehdi Mortazavi

Biofabrication, 2024, 16, 022005
DOI: 10.1088/1758-5090/ad22ed

Vasculature-On-A-Chip for In Vitro Disease Models

Seunggyu Kim, Wanho Kim, Seongjin Lim and Jessie Jeon

Bioengineering, 2017, 4, 8
DOI: 10.3390/bioengineering4010008

3D kidney organoids for bench-to-bedside translation

Navin Gupta✉, Emre Dilmen and Ryuji Morizane

J Mol Med, 2021, 99, 477
DOI: 10.1007/s00109-020-01983-y

Fabrication of multilayered vascular tissues using microfluidic agarose hydrogel platforms

Keita Kinoshita, Masaki Iwase, Masumi Yamada, Yuya Yajima and Minoru Seki

Biotechnology Journal, 2016, 11, 1415
DOI: 10.1002/biot.201600083

Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening

Vincent van Duinen, Wendy Stam, Eva Mulder, Farbod Famili, Arie Reijerkerk, Paul Vulto, Thomas Hankemeier and Anton Jan van Zonneveld

IJMS, 2020, 21, 4804
DOI: 10.3390/ijms21134804

Mechanotransduction alterations in tissue-engineered tumor models for new drug interventions

Nipun Jain, Yusuf Olatunji Waidi, Souvik Debnath, Vilay Vannaladsaysy and Sudipto Datta

PPIJ, 2024, 12, 148
DOI: 10.15406/ppij.2024.12.00446

Recent advances in microfluidics for drug screening

Jiahui Sun, Antony R. Warden and Xianting Ding

Biomicrofluidics, 2019, 13, 061503
DOI: 10.1063/1.5121200

Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning

Joshua Loessberg-Zahl, Jelle Beumer, Albert van den Berg, Jan Eijkel and Andries van der Meer

Micromachines, 2020, 11, 1112
DOI: 10.3390/mi11121112

Microfluidic Device for the Analysis of Angiogenic Sprouting under Bidirectional Biochemical Gradients

Keigo Nishimura, Minghao Nie, Shigenori Miura and Shoji Takeuchi

Micromachines, 2020, 11, 1049
DOI: 10.3390/mi11121049

Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery

Pranay Agarwal, Hai Wang, Mingrui Sun, Jiangsheng Xu, Shuting Zhao, Zhenguo Liu, Keith J. Gooch, Yi Zhao, Xiongbin Lu and Xiaoming He

ACS Nano, 2017, 11, 6691
DOI: 10.1021/acsnano.7b00824

Engineered in vitro tumor models for cell-based immunotherapy

Yuta Ando, Chelsea Mariano and Keyue Shen

Acta Biomaterialia, 2021, 132, 345
DOI: 10.1016/j.actbio.2021.03.076

An Easy-to-Fabricate Microfluidic Shallow Trench Induced Three-Dimensional Cell Culturing and Imaging (STICI3D) Platform

Umut Can Coskun, Funda Kus, Ateeq Ur Rehman, Berna Morova, Merve Gulle, Hatice Baser, Demet Kul, Alper Kiraz, Kemal Baysal and Ahmet Erten

ACS Omega, 2022, 7, 8281
DOI: 10.1021/acsomega.1c05118

Study of diffusive- and convective-transport mediated microtumor growth in a controlled microchamber

Yu-Hsiang Hsu, Wei-Wen Liu, Tung-Han Wu, Carina Jean-Tien Lee, Yu-Hsi Chen and Pai-Chi Li

Biomed Microdevices, 2019, 21
DOI: 10.1007/s10544-018-0356-7

Application of microfluidic chip technology in pharmaceutical analysis: A review

Ping Cui and Sicen Wang

Journal of Pharmaceutical Analysis, 2019, 9, 238
DOI: 10.1016/j.jpha.2018.12.001

Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts

Somin Lee, Hyunkyung Kim, Bum Suk Kim, Sehyun Chae, Sangmin Jung, Jung Seub Lee, James Yu, Kyungmin Son, Minhwan Chung, Jong Kyoung Kim, Daehee Hwang, Sung Hee Baek and Noo Li Jeon

Nat Commun, 2024, 15
DOI: 10.1038/s41467-023-44427-0

Engineering cancer microenvironments for in vitro 3-D tumor models

Waseem Asghar, Rami El Assal, Hadi Shafiee, Sharon Pitteri, Ramasamy Paulmurugan and Utkan Demirci

Materials Today, 2015, 18, 539
DOI: 10.1016/j.mattod.2015.05.002

Transparent PDMS Bioreactors for the Fabrication and Analysis of Multi-Layer Pre-vascularized Hydrogels Under Continuous Perfusion

Juan Liu, Huaiyuan Zheng, Xinyi Dai, Patrina S. P. Poh, Hans-Günther Machens and Arndt F. Schilling

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.568934

Extrusion-based printing of sacrificial Carbopol ink for fabrication of microfluidic devices

Veli Ozbolat, Madhuri Dey, Bugra Ayan and Ibrahim T Ozbolat

Biofabrication, 2019, 11, 034101
DOI: 10.1088/1758-5090/ab10ae

Design criteria and standardization of a microfluidic cell culture system for investigating cellular migration

Young Lee, Gihyun Lee, Minkyung Cho and Je-Kyun Park

J. Micromech. Microeng., 2019, 29, 043003
DOI: 10.1088/1361-6439/ab0796

Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip

Lang Zhou, Lunan Liu, Muammar Ali Chang, Chao Ma, Weiqiang Chen and Pengyu Chen

Biosensors and Bioelectronics, 2023, 225, 115064
DOI: 10.1016/j.bios.2023.115064

Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system

Chutong Tian, Shunzhe Zheng, Xinying Liu and Ken-ichiro Kamei

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01552-0

Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule

Nan Zhao, Sarah Kulkarni, Sophia Zhang, Raleigh M. Linville, Tracy D. Chung, Zhaobin Guo, John J. Jamieson, Danielle Norman, Lily Liang, Alexander F. Pessell and Peter Searson

Angiogenesis, 2023, 26, 203
DOI: 10.1007/s10456-023-09868-7

3D Microfluidic Platform and Tumor Vascular Mapping for Evaluating Anti-Angiogenic RNAi-Based Nanomedicine

Somin Lee, Seongchan Kim, Dong-Jun Koo, James Yu, Hyeongjun Cho, Hyojin Lee, Joon Myong Song, Sung-Yon Kim, Dal-Hee Min and Noo Li Jeon

ACS Nano, 2021, 15, 338
DOI: 10.1021/acsnano.0c05110

Toward improved in vitro models of human cancer

Jose M. Ayuso, Keon-Young Park, María Virumbrales-Muñoz and David J. Beebe

APL Bioengineering, 2021, 5
DOI: 10.1063/5.0026857

Cancer Metastasis‐on‐a‐Chip for Modeling Metastatic Cascade and Drug Screening

Anastasia Brooks, Yali Zhang, Jiezhong Chen and Chun‐Xia Zhao

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202302436

Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases

Subhathirai Subramaniyan Parimalam, Simona Badilescu, Nahum Sonenberg, Rama Bhat and Muthukumaran Packirisamy

IJMS, 2019, 20, 6126
DOI: 10.3390/ijms20246126

Angiogenic Sprouting Dynamics Mediated by Endothelial‐Fibroblast Interactions in Microfluidic Systems

Noosheen Walji, Sina Kheiri and Edmond W. K. Young

Advanced Biology, 2021, 5
DOI: 10.1002/adbi.202101080

Matrix Resistance Toward Proteolytic Cleavage Controls Contractility‐Dependent Migration Modes During Angiogenic Sprouting

Martin S. Weiß, Giuseppe Trapani, Hongyan Long and Britta Trappmann

Advanced Science, 2024, 11
DOI: 10.1002/advs.202305947

Remodeling of an in vitro microvessel exposed to cyclic mechanical stretch

Soheila Zeinali, Emily K. Thompson, Holger Gerhardt, Thomas Geiser and Olivier T. Guenat

APL Bioengineering, 2021, 5
DOI: 10.1063/5.0010159

The Efficacy and Mechanism of Proteasome Inhibitors in Solid Tumor Treatment

Lei Zhang, Mengyang Wu, Ruicong Su, Di Zhang and Guilian Yang

PRA, 2022, 17, 268
DOI: 10.2174/1574892816666211202154536

Biofabrication strategies for creating microvascular complexity

Alisa Morss Clyne, Swathi Swaminathan and Andrés Díaz Lantada

Biofabrication, 2019, 11, 032001
DOI: 10.1088/1758-5090/ab0621

Advances in Spheroids and Organoids on a Chip

Guocheng Fang, Yu‐Cheng Chen, Hongxu Lu and Dayong Jin

Adv Funct Materials, 2023, 33
DOI: 10.1002/adfm.202215043

Synergistic Combination of Additive One‐ and Two‐Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis–on–a–Chip Systems

Daria Sokoliuk, Rizlene Bouhaya, Peter Haeger, Kathrin Godthardt, Daniel Fetting, Lenard Spiecker, Heinrich Spiecker, Alexander Rockenbach, Holger Rothe, Klaus Liefeith and Doris Heinrich

Engineering in Life Sciences, 2026, 26
DOI: 10.1002/elsc.70059

Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies

Marco Campisi, Sarah E. Shelton, Minyue Chen, Roger D. Kamm, David A. Barbie and Erik H. Knelson

Cancers, 2022, 14, 3561
DOI: 10.3390/cancers14153561

Successes and future outlook for microfluidics-based cardiovascular drug discovery

Joanna Skommer and Donald Wlodkowic

Expert Opinion on Drug Discovery, 2015, 10, 231
DOI: 10.1517/17460441.2015.1001736

Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events

Jose M. Ayuso, Rosa Monge, Alicia Martínez-González, María Virumbrales-Muñoz, Guillermo A. Llamazares, Javier Berganzo, Aurelio Hernández-Laín, Jorge Santolaria, Manuel Doblaré, Christopher Hubert, Jeremy N. Rich, Pilar Sánchez-Gómez, Víctor M. Pérez-García, Ignacio Ochoa and Luis J. Fernández

NEUONC, 2017, now230
DOI: 10.1093/neuonc/now230

Fibroblasts mediate endothelium response to angiogenic cues in a newly developed 3D stroma engineered model

Alessandra Dellaquila, Chloé Dujardin, Chau Le Bao, Chloé Chaumeton, Albane Carré, Camille Le Guilcher, France Lam and Teresa Simon-Yarza

Biomaterials Advances, 2023, 154, 213636
DOI: 10.1016/j.bioadv.2023.213636

A microfluidic mammary gland coculture model using parallel 3D lumens for studying epithelial-endothelial migration in breast cancer

Deepika Devadas, Thomas A. Moore, Noosheen Walji and Edmond W. K. Young

Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5123912

Hydrogel engineering for cardiac patches and cardiovascular organ-on-a-chip

Qingtong Liu, Haiyan Zhang, Xiatong Pan, Jun Chen, Weiguang Su, Anqing Li, Guohua Liu and Li Wang

Chemical Engineering Journal, 2025, 525, 169964
DOI: 10.1016/j.cej.2025.169964

Microphysiological Systems: Design, Fabrication, and Applications

Kai Wang, Kun Man, Jiafeng Liu, Yang Liu, Qi Chen, Yong Zhou and Yong Yang

ACS Biomater. Sci. Eng., 2020, 6, 3231
DOI: 10.1021/acsbiomaterials.9b01667

Transport of vascular endothelial growth factor dictates on-chip angiogenesis in tumor microenvironment

Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das and Suman Chakraborty

Physics of Fluids, 2021, 33
DOI: 10.1063/5.0042487

Stem cell-based vascularization of microphysiological systems

Shane Browne, Elisabeth L. Gill, Paula Schultheiss, Ishan Goswami and Kevin E. Healy

Stem Cell Reports, 2021, 16, 2058
DOI: 10.1016/j.stemcr.2021.03.015

Rebuilding the Vascular Network: In vivo and in vitro Approaches

Xiangfu Meng, Yunhui Xing, Jiawen Li, Cechuan Deng, Yifei Li, Xi Ren and Donghui Zhang

Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.639299

Bio-inspired microfluidics: A review

Kiran Raj M, Jyotsana Priyadarshani, Pratyaksh Karan, Saumyadwip Bandyopadhyay, Soumya Bhattacharya and Suman Chakraborty

Biomicrofluidics, 2023, 17
DOI: 10.1063/5.0161809

Tumor cells and their crosstalk with endothelial cells in 3D spheroids

Hila Shoval, Adi Karsch-Bluman, Yifat Brill-Karniely, Tal Stern, Gideon Zamir, Ayala Hubert and Ofra Benny

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-10699-y

Engineering a microfluidic platform for cell extravasation monitoring and downstream characterization of disseminated cells

Aude Sivéry, Flavie Woesteland, Jérémy Duval, Marie Denoulet, Fabrice Soncin, Xuefen Le Bourhis, Anthony Treizebré and Chann Lagadec

Biomicrofluidics, 2025, 19
DOI: 10.1063/5.0279981

Complex 3D‐Printed Microchannels within Cell‐Degradable Hydrogels

Kwang Hoon Song, Christopher B. Highley, Andrew Rouff and Jason A. Burdick

Adv Funct Materials, 2018, 28
DOI: 10.1002/adfm.201801331

Biochemical analysis on microfluidic chips

Jing Wu, Ziyi He, Qiushui Chen and Jin-Ming Lin

TrAC Trends in Analytical Chemistry, 2016, 80, 213
DOI: 10.1016/j.trac.2016.03.013

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device

Jose M. Ayuso, Haneen A. Basheer, Rosa Monge, Pablo Sánchez-Álvarez, Manuel Doblaré, Steven D. Shnyder, Victoria Vinader, Kamyar Afarinkia, Luis J. Fernández, Ignacio Ochoa and Christopher V. Rao

PLoS ONE, 2015, 10, e0139515
DOI: 10.1371/journal.pone.0139515

Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips

Julian Gonzalez‐Rubio, Hannah Kubiza, Yong Xu, Hiltrud Koenigs‐Werner, Mona Sophie Schmitz, Michaela Schedel, Christian Apel, Stefan Jockenhoevel, Christian G. Cornelissen and Anja Lena Thiebes

Advanced Science, 2025, 12
DOI: 10.1002/advs.202408131

Recapitulating the Vasculature Using Organ-On-Chip Technology

Andreas M.A.O. Pollet and Jaap M.J. den Toonder

Bioengineering, 2020, 7, 17
DOI: 10.3390/bioengineering7010017

A Versatile and Fully Integrated Hand-Held Device for Microfluidic-Based Biosensing: A Case Study of Plant Health Biomarkers

Eduardo J. S. Bras, Rui M. R. Pinto, Virginia Chu, Pedro Fernandes and Joao Pedro Conde

IEEE Sensors J., 2020, 20, 14007
DOI: 10.1109/JSEN.2020.3007023

Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery

Jing Bai and Chunming Wang

Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.00407

An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer‐Associated Angiogenesis Studies

Heshu Sulaiman Rahman, Bee Ling Tan, Hemn Hassan Othman, Max Stanley Chartrand, Yashwant Pathak, Syam Mohan, Rasedee Abdullah, Noorjahan Banu Alitheen and Baotong Zhang

BioMed Research International, 2020, 2020
DOI: 10.1155/2020/8857428

Building Blood Vessel Chips with Enhanced Physiological Relevance

Xuan Mu, Marie Denise Gerhard‐Herman and Yu Shrike Zhang

Adv Materials Technologies, 2023, 8
DOI: 10.1002/admt.202201778

Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis

Nitish Peela, Danh Truong, Harpinder Saini, Hunghao Chu, Samaneh Mashaghi, Stephanie L. Ham, Sunil Singh, Hossein Tavana, Bobak Mosadegh and Mehdi Nikkhah

Biomaterials, 2017, 133, 176
DOI: 10.1016/j.biomaterials.2017.04.017

Advanced technological tools to study multidrug resistance in cancer

Luca Andrei, Sandor Kasas, Ignacio Ochoa Garrido, Tijana Stanković, Mónica Suárez Korsnes, Radka Vaclavikova, Yehuda G. Assaraf and Milica Pešić

Drug Resistance Updates, 2020, 48, 100658
DOI: 10.1016/j.drup.2019.100658

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

Pratibha Parihar, Naina Sunildutt, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Jong Hwan Lim and Kyung Hyun Choi

Advanced Therapeutics, 2024, 7
DOI: 10.1002/adtp.202300410

Replacement in angiogenesis research: Studying mechanisms of blood vessel development by animal-free in vitro, in vivo and in silico approaches

Matthias W. Laschke, Yuan Gu and Michael D. Menger

Front. Physiol., 2022, 13
DOI: 10.3389/fphys.2022.981161

Microfluidics in Malignant Glioma Research and Precision Medicine

Meghan Logun, Wujun Zhao, Leidong Mao and Lohitash Karumbaiah

Adv. Biosys., 2018, 2
DOI: 10.1002/adbi.201700221

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai, Igor Astsaturov, Edna Cukierman, David G. DeNardo, Mikala Egeblad, Ronald M. Evans, Douglas Fearon, Florian R. Greten, Sunil R. Hingorani, Tony Hunter, Richard O. Hynes, Rakesh K. Jain, Tobias Janowitz, Claus Jorgensen, Alec C. Kimmelman, Mikhail G. Kolonin, Robert G. Maki, R. Scott Powers, Ellen Puré, Daniel C. Ramirez, Ruth Scherz-Shouval, Mara H. Sherman, Sheila Stewart, Thea D. Tlsty, David A. Tuveson, Fiona M. Watt, Valerie Weaver, Ashani T. Weeraratna and Zena Werb

Nat Rev Cancer, 2020, 20, 174
DOI: 10.1038/s41568-019-0238-1

In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies

Mehdi Rahmanian, Amir Seyfoori, Mohsen Ghasemi, Milad Shamsi, Ahmad Rezaei Kolahchi, Hassan Pezeshgi Modarres, Amir Sanati-Nezhad and Keivan Majidzadeh-A

Journal of Controlled Release, 2021, 334, 164
DOI: 10.1016/j.jconrel.2021.04.024

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform

V. van Duinen, D. Zhu, C. Ramakers, A. J. van Zonneveld, P. Vulto and T. Hankemeier

Angiogenesis, 2019, 22, 157
DOI: 10.1007/s10456-018-9647-0

Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen and Zhilu Yang

Bioactive Materials, 2022, 9, 198
DOI: 10.1016/j.bioactmat.2021.07.005

Microfluidic models for adoptive cell-mediated cancer immunotherapies

Giulia Adriani, Andrea Pavesi, Anthony T. Tan, Antonio Bertoletti, Jean Paul Thiery and Roger D. Kamm

Drug Discovery Today, 2016, 21, 1472
DOI: 10.1016/j.drudis.2016.05.006

Frugal Approach toward Developing a Biomimetic, Microfluidic Network-on-a-Chip for In Vitro Analysis of Microvascular Physiology

Jyotsana Priyadarshani, Trina Roy, Soumen Das and Suman Chakraborty

ACS Biomater. Sci. Eng., 2021, 7, 1263
DOI: 10.1021/acsbiomaterials.1c00070

Antagonizing the S1P-S1P3 Axis as a Promising Anti-Angiogenic Strategy

Sofia Avnet, Emi Mizushima, Beatrice Severino, Maria Veronica Lipreri, Antonia Scognamiglio, Angela Corvino, Nicola Baldini and Margherita Cortini

Metabolites, 2025, 15, 178
DOI: 10.3390/metabo15030178

Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling

Ngan Nguyen, Peter Thurgood, Nadia Chandra Sekar, Sheng Chen, Elena Pirogova, Karlheinz Peter, Sara Baratchi and Khashayar Khoshmanesh

Biophys Rev, 2021, 13, 769
DOI: 10.1007/s12551-021-00815-8

Functionally-Relevant Morphological Profiling: A Tool to Assess Cellular Heterogeneity

Ross A. Marklein, Johnny Lam, Murat Guvendiren, Kyung E. Sung and Steven R. Bauer

Trends in Biotechnology, 2018, 36, 105
DOI: 10.1016/j.tibtech.2017.10.007

Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks

Honesty Kim, Grace Hu, Austin J. Graham, Grace X. Gu and Zev J. Gartner

Cold Spring Harb Perspect Biol, 2025, 17, a041557
DOI: 10.1101/cshperspect.a041557

A review of organ-on-chip fabrication methods: From early developments to overcoming inert barriers

Claudia Olaizola-Rodrigo, Clara Bayona, Sara Oliván and Rosa Monge

iScience, 2025, 28, 113992
DOI: 10.1016/j.isci.2025.113992

Nanoliter Centrifugal Liquid Dispenser Coupled with Superhydrophobic Microwell Array Chips for High-Throughput Cell Assays

Yuyi Wang, Yushuai Wu, Yue Chen, Jianxiong Zhang, Xiaofang Chen and Peng Liu

Micromachines, 2018, 9, 286
DOI: 10.3390/mi9060286

Bioreaktoren für vaskularisiertes Knochen-Tissue-Engineering

Kai O. Böker, Samuel Siegk, Luis A. Pardo, Miguel Bravo, Janne Hahne, Wolfgang Lehmann and Arndt F. Schilling

Biospektrum, 2022, 28, 654
DOI: 10.1007/s12268-022-1833-3

Microfluidic Collective Cell Migration Assay for Study of Endothelial Cell Proliferation and Migration under Combinations of Oxygen Gradients, Tensions, and Drug Treatments

Hsiu-Chen Shih, Tse-Ang Lee, Hsiao-Mei Wu, Ping-Liang Ko, Wei-Hao Liao and Yi-Chung Tung

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-44594-5

Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation

José Alexandre Ferreira, Andreia Peixoto, Manuel Neves, Cristiana Gaiteiro, Celso A. Reis, Yehuda G. Assaraf and Lúcio Lara Santos

Drug Resistance Updates, 2016, 24, 34
DOI: 10.1016/j.drup.2015.11.003

Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing

Nicola Di Marzio, Preeta Ananthanarayanan, Anne Géraldine Guex, Mauro Alini, Chiara Riganti and Tiziano Serra

Materials Today Bio, 2022, 16, 100357
DOI: 10.1016/j.mtbio.2022.100357

Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives

Daisy Rabbitt, Victor M. Villapún, Luke N. Carter, Kenny Man, Morgan Lowther, Paraic O'Kelly, Alexander J. Knowles, Alessandro Mottura, Yuanbo T. Tang, Lorenzo Luerti, Roger C. Reed and Sophie C. Cox

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202403129

Mechanical Forces in Tumor Growth and Treatment: Perspectives From Biology, Physics, Engineering, and Mathematical Modeling

Farshad Moradi Kashkooli, Fatemeh Mirala, Masoud H. H. Tehrani, Mahvash Alirahimi, Mohammad Souri, Aryan Golzaryan, Saptarshi Kar and Madjid Soltani

WIREs Mechanisms of Disease, 2025, 17
DOI: 10.1002/wsbm.70000

A 3D vascularized tumor spheroid microfluidic platform for head and neck cancer research: new insights

Jooin Bang, Jiyoung Yeo, Su Ji Lee, Hansol Lee, Jinyoung Kim, Sohyeon Jeong, Eeseul Kang, Hoon Suk Rho, YongTae Kim and Jun-Ook Park

Biomed Microdevices, 2025, 27
DOI: 10.1007/s10544-025-00748-z

Engineered Vasculature for Cancer Research and Regenerative Medicine

Huu Tuan Nguyen, Arne Peirsman, Zuzana Tirpakova, Kalpana Mandal, Florian Vanlauwe, Surjendu Maity, Satoru Kawakita, Danial Khorsandi, Rondinelli Herculano, Christian Umemura, Can Yilgor, Remy Bell, Adrian Hanson, Shaopei Li, Himansu Sekhar Nanda, Yangzhi Zhu, Alireza Hassani Najafabadi, Vadim Jucaud, Natan Barros, Mehmet Remzi Dokmeci and Ali Khademhosseini

Micromachines, 2023, 14, 978
DOI: 10.3390/mi14050978

A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models

Nathalie Picollet-D’hahan, Monika E. Dolega, Lavinia Liguori, Christophe Marquette, Séverine Le Gac, Xavier Gidrol and Donald K. Martin

Trends in Biotechnology, 2016, 34, 757
DOI: 10.1016/j.tibtech.2016.06.012

Platelet bioreactor: accelerated evolution of design and manufacture

Jonathan N. Thon, Brad J. Dykstra and Lea M. Beaulieu

Platelets, 2017, 28, 472
DOI: 10.1080/09537104.2016.1265922

Engineering New Microvascular Networks On‐Chip: Ingredients, Assembly, and Best Practices

James J. Tronolone and Abhishek Jain

Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202007199

G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

L. F. F. Bittencourt, G. L. Negreiros-Lima, L. P. Sousa, A. G. Silva, I. B. S. Souza, R. I. M. A. Ribeiro, M. F. Dutra, R. F. Silva, A. C. F. Dias, F. M. Soriani, W. K. Martins and L. S. Barcelos

J Neurooncol, 2019, 144, 463
DOI: 10.1007/s11060-019-03252-6

A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth

Mohammad Reza Nikmaneshi, Bahar Firoozabadi, Aliasghar Mozafari and Lance L. Munn

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-59658-0

A framework for the rational design of oncolytic viruses: A holistic perspective considering the tumour microenvironment

Dylan Thomas, Priya Bharadwa, Timothy Lee and Carolina S. Ilkow

Seminars in Immunology, 2025, 79, 101977
DOI: 10.1016/j.smim.2025.101977

Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing

Vikram Surendran, Simrit Safarulla, Christian Griffith, Reem Ali, Ankit Madan, William Polacheck and Arvind Chandrasekaran

ACS Appl. Mater. Interfaces, 2024, 16, 47075
DOI: 10.1021/acsami.4c01766

Advances of Microfluidic Technologies Applied in Bio-analytical Chemistry

Feng ZHANG, Dan GAO and Qiong-Lin LIANG

Chinese Journal of Analytical Chemistry, 2016, 44, 1942
DOI: 10.1016/S1872-2040(16)60982-9

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova and Andries D. van der Meer

Advanced Drug Delivery Reviews, 2019, 140, 68
DOI: 10.1016/j.addr.2018.06.007

Bioprinting for Liver Transplantation

Christina Kryou, Valentina Leva, Marianneza Chatzipetrou and Ioanna Zergioti

Bioengineering, 2019, 6, 95
DOI: 10.3390/bioengineering6040095

The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?

Darren Rodenhizer, Teresa Dean, Elisa D'Arcangelo and Alison P. McGuigan

Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201701174

Tumor Microenvironment on a Chip: The Progress and Future Perspective

Jungho Ahn, Yoshitaka Sei, Noo Jeon and YongTae Kim

Bioengineering, 2017, 4, 64
DOI: 10.3390/bioengineering4030064

Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model

Christian F. E. Jones, Stefania Di Cio, John T. Connelly and Julien E. Gautrot

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.915702

Microfluidic Reconstitution of Tumor Microenvironment for Nanomedical Applications

Hyun Jeong Oh, Jaehoon Kim, Hyunho Kim, Nakwon Choi and Seok Chung

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202002122

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

Aleksander Skardal, Thomas Shupe and Anthony Atala

Drug Discovery Today, 2016, 21, 1399
DOI: 10.1016/j.drudis.2016.07.003

Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair

Yaqi You, Kazuya Kobayashi, Burcu Colak, Piaopiao Luo, Edward Cozens, Laura Fields, Ken Suzuki and Julien Gautrot

Biomaterials, 2021, 269, 120356
DOI: 10.1016/j.biomaterials.2020.120356

Oxymatrine and cancer therapy

WW Lu, R Zhang, JS Zhu, LQ Xia and J Zhang

Eur J Inflamm, 2015, 13, 148
DOI: 10.1177/1721727X15613911

Analysis of the Internal Hypoxic Environment in Solid Tumor Tissue Using a Folding Paper System

Chia-Hao Huang, Kowit-Yu Chong and Kin Fong Lei

ACS Appl. Mater. Interfaces, 2021, 13, 33885
DOI: 10.1021/acsami.1c08857

In Vitro Microfluidic Models for Neurodegenerative Disorders

Tatsuya Osaki, Yoojin Shin, Vivek Sivathanu, Marco Campisi and Roger D. Kamm

Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700489