Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

Rudolf Wedmann, Constantin Onderka, Shengwei Wei, István András Szijártó, Jan Lj. Miljkovic, Aleksandra Mitrovic, Mike Lange, Sergey Savitsky, Pramod Kumar Yadav, Roberta Torregrossa, Ellen G. Harrer, Thomas Harrer, Isao Ishii, Maik Gollasch, Mark E. Wood, Erwan Galardon, Ming Xian, Matthew Whiteman, Ruma Banerjee and Milos R. Filipovic

Chem. Sci., 2016, 7, 3414
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“On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor

Prashant Shukla, Vinayak S. Khodade, Mallojjala SharathChandra, Preeti Chauhan, Saurabh Mishra, Shivakumara Siddaramappa, Bulagonda Eswarappa Pradeep, Amit Singh and Harinath Chakrapani

Chem. Sci., 2017, 8, 4967
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Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137

Benjamin E. Alexander, Simon J. Coles, Bridget C. Fox, Tahmina F. Khan, Joseph Maliszewski, Alexis Perry, Mateusz B. Pitak, Matthew Whiteman and Mark E. Wood

Med. Chem. Commun., 2015, 6, 1649
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H2S donor molecules against cold ischemia-reperfusion injury in preclinical models of solid organ transplantation

George J. Dugbartey, Smriti Juriasingani, Max Y. Zhang and Alp Sener

Pharmacological Research, 2021, 172, 105842
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Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans

Adriana Raluca Vintila, Luke Slade, Michael Cooke, Craig R. G. Willis, Roberta Torregrossa, Mizanur Rahman, Taslim Anupom, Siva A. Vanapalli, Christopher J. Gaffney, Nima Gharahdaghi, Csaba Szabo, Nathaniel J. Szewczyk, Matthew Whiteman and Timothy Etheridge

Proc. Natl. Acad. Sci. U.S.A., 2023, 120
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Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

John L. Wallace and Rui Wang

Nat Rev Drug Discov, 2015, 14, 329
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Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms

Athanasia Chatzianastasiou, Sofia-Iris Bibli, Ioanna Andreadou, Panagiotis Efentakis, Nina Kaludercic, Mark E. Wood, Matthew Whiteman, Fabio Di Lisa, Andreas Daiber, Vangelis G. Manolopoulos, Csaba Szabó and Andreas Papapetropoulos

The Journal of Pharmacology and Experimental Therapeutics, 2016, 358, 431
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Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

Li Theng Ng, Li Fang Ng, Richard Ming Yi Tang, Diogo Barardo, Barry Halliwell, Philip Keith Moore and Jan Gruber

npj Aging Mech Dis, 2020, 6
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The mitochondria‐targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model

Bridget C. Fox, Luke Slade, Roberta Torregrossa, Dario Pacitti, Csaba Szabo, Timothy Etheridge and Matthew Whiteman

J of Inher Metab Disea, 2021, 44, 367
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A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

Csaba Szabo

Biochemical Pharmacology, 2018, 149, 5
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Mitochondria-targeted hydrogen sulfide donor reduces atherogenesis by changing macrophage phenotypes and increasing UCP1 expression in vascular smooth muscle cells

Aneta Stachowicz, Anna Wiśniewska, Klaudia Czepiel, Bartosz Pomierny, Alicja Skórkowska, Beata Kuśnierz-Cabala, Marcin Surmiak, Katarzyna Kuś, Mark E. Wood, Roberta Torregrossa, Matthew Whiteman and Rafał Olszanecki

Biomedicine & Pharmacotherapy, 2024, 180, 117527
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Mitochondria Targeting Fluorescent Probes Based on through Bond‐Energy Transfer for Mutually Imaging Signaling Molecules H2S and H2O2

Jian Sun, Xiao Li, Jia Cao, Qi Sun, Yajie Zhang, Xuewei Wang, Tiantian Wu, Xiantao Hu and Fude Feng

Chemistry A European J, 2019, 25, 9164
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A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria

Hiroyuki Yamakoshi, Almar Palonpon, Kosuke Dodo, Jun Ando, Satoshi Kawata, Katsumasa Fujita and Mikiko Sodeoka

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 664
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The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood and Matthew Whiteman

Pharmacological Research, 2016, 113, 186
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Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion

Smriti Juriasingani, Ashley Jackson, Max Yulin Zhang, Aushanth Ruthirakanthan, George J. Dugbartey, Emrullah Sogutdelen, Max Levine, Moaath Mandurah, Matthew Whiteman, Patrick Luke and Alp Sener

IJMS, 2021, 22, 7180
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Hydrogen Sulfide Is a Novel Protector of the Retinal Glycocalyx and Endothelial Permeability Barrier

Claire L. Allen, Katarzyna Wolanska, Naseeb K. Malhi, Andrew V. Benest, Mark E. Wood, Winfried Amoaku, Roberta Torregrossa, Matthew Whiteman, David O. Bates and Jacqueline L. Whatmore

Front. Cell Dev. Biol., 2021, 9
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Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model

Rebecca A. Ellwood, Jennifer E. Hewitt, Roberta Torregrossa, Ashleigh M. Philp, Justin P. Hardee, Samantha Hughes, David van de Klashorst, Nima Gharahdaghi, Taslim Anupom, Luke Slade, Colleen S. Deane, Michael Cooke, Timothy Etheridge, Mathew Piasecki, Adam Antebi, Gordon S. Lynch, Andrew Philp, Siva A. Vanapalli, Matthew Whiteman and Nathaniel J. Szewczyk

Proc. Natl. Acad. Sci. U.S.A., 2021, 118
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Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice

Kohei Ikeda, Eizo Marutani, Shuichi Hirai, Mark E. Wood, Matthew Whiteman and Fumito Ichinose

Nitric Oxide, 2015, 49, 90
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Vinylphosphonium and 2-aminovinylphosphonium salts – preparation and applications in organic synthesis

Anna Kuźnik, Roman Mazurkiewicz and Beata Fryczkowska

Beilstein J. Org. Chem., 2017, 13, 2710
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Hydrogen sulfide supplementation as a potential treatment for primary mitochondrial diseases

Luke Slade, Colleen S. Deane, Nathaniel J. Szewczyk, Timothy Etheridge and Matthew Whiteman

Pharmacological Research, 2024, 203, 107180
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Mitochondria-Targeted Hydrogen Sulfide Delivery Molecules Protect Against UVA-Induced Photoaging in Human Dermal Fibroblasts, and in Mouse Skin In Vivo

Jinapath Lohakul, Saowanee Jeayeng, Anyamanee Chaiprasongsuk, Roberta Torregrossa, Mark. E. Wood, Malinee Saelim, Weerawon Thangboonjit, Matthew Whiteman and Uraiwan Panich

Antioxidants & Redox Signaling, 2022, 36, 1268
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Subcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress

Annie K. Gilbert and Michael D. Pluth

J. Am. Chem. Soc., 2022, 144, 17651
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The Mitochondria-Targeted H2S-Donor AP39 in a Murine Model of Combined Hemorrhagic Shock and Blunt Chest Trauma

Martin Wepler, Tamara Merz, Ulrich Wachter, Josef Vogt, Enrico Calzia, Angelika Scheuerle, Peter Möller, Michael Gröger, Sandra Kress, Marina Fink, Britta Lukaschewski, Grégoire Rumm, Bettina Stahl, Michael Georgieff, Markus Huber-Lang, Roberta Torregrossa, Matthew Whiteman, Oscar McCook, Peter Radermacher and Clair Hartmann

Shock, 2019, 52, 230
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Small-molecule inhibition of the archetypal UbiB protein COQ8

Nathan H. Murray, Christopher R. M. Asquith, Zixiang Fang, Michael P. East, Naomi Ptak, Robert W. Smith, James D. Vasta, Chad A. Zimprich, Cesear R. Corona, Matthew B. Robers, Gary L. Johnson, Craig A. Bingman and David J. Pagliarini

Nat Chem Biol, 2023, 19, 230
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Synthesis, characterization and antimicrobial activity of β-aminovinylphosphonium salts derived from aromatic amino acids

Sergey A. Borodkin, Leonid D. Popov, Milica R. Milenković, Marina Milenković, Svetlana Belošević, Katarina Anđelković, Arshak A. Tsaturyan and Igor N. Shcherbakov

Phosphorus, Sulfur, and Silicon and the Related Elements, 2017, 192, 1079
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Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity

Xu Cao, Siping Xiong, Yebo Zhou, Zhiyuan Wu, Lei Ding, Yike Zhu, Mark E. Wood, Matthew Whiteman, Philip K. Moore and Jin-song Bian

Antioxidants & Redox Signaling, 2018, 29, 455
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Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents

Wei Feng, Wisna Novera, Kaye Peh, Donavan Neo, Pondy Murugappan Ramanujulu, Philip K. Moore, Lih-Wen Deng and Brian W. Dymock

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 967
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The Hydrogen Sulfide Donor AP39 Reduces Glutamate-mediated Excitotoxicity in a Rat Model of Brain Ischemia

Alicja Skórkowska, Weronika Krzyżanowska, Beata Bystrowska, Roberta Torregrossa, Matthew Whiteman, Bartosz Pomierny and Bogusława Budziszewska

Neuroscience, 2024, 539, 86
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An iridium(III) complex-based luminogenic probe for high-throughput screening of hydrogen sulfide donors in living cells

Ke-Jia Wu, Wen Sun, Jian-Min Sun, Chang Lu, Ning Sun, Chung‐Hang Leung, Yan Li and Chun Wu

Commun Chem, 2024, 7
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Synthesis, Structure, and Properties of Novel Enamine Containing Coumarin and Phosphonium Fragments

L. D. Popov, I. N. Scherbakov, S. A. Borodkin, Yu. V. Revinskii, E. A. Kazoyan, G. A. Shaginyan, A. R. Sarkisyan and Sh. A. Markaryan

Russ J Gen Chem, 2019, 89, 906
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Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease

Zsolt Combi, László Potor, Péter Nagy, Katalin Éva Sikura, Tamás Ditrói, Eszter Petra Jurányi, Klaudia Galambos, Tamás Szerafin, Péter Gergely, Matthew Whiteman, Roberta Torregrossa, Yuchao Ding, Lívia Beke, Zoltán Hendrik, Gábor Méhes, György Balla and József Balla

Redox Biology, 2023, 60, 102629
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Strategies for gaseous neuromodulator release in chemical neuroscience: Experimental approaches and translational validation

Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir and Sandeep Verma

Journal of Controlled Release, 2024, 365, 132
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Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels

Lenka Tomasova, Michaela Pavlovicova, Lubica Malekova, Anton Misak, Frantisek Kristek, Marian Grman, Sona Cacanyiova, Milan Tomasek, Zuzana Tomaskova, Alexis Perry, Mark E. Wood, Lubica Lacinova, Karol Ondrias and Matthew Whiteman

Nitric Oxide, 2015, 46, 131
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Novel Regulatory Roles of Hydrogen Sulfide in Health and Disease

Csaba Szabo

Biomolecules, 2022, 12, 1372
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AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling

Qutuba G Karwi, Julia Bornbaum, Kerstin Boengler, Roberta Torregrossa, Matthew Whiteman, Mark E Wood, Rainer Schulz and Gary F Baxter

British Journal of Pharmacology, 2017, 174, 287
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Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging

Dario Pacitti, Chris J. Scotton, Vinod Kumar, Haroon Khan, Peter A.B. Wark, Roberta Torregrossa, Philip M. Hansbro and Matthew Whiteman

Antioxidants & Redox Signaling, 2021, 35, 551
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Mechanistic Insights into the H2S-Mediated Reduction of Aryl Azides Commonly Used in H2S Detection

Hillary A. Henthorn and Michael D. Pluth

J. Am. Chem. Soc., 2015, 137, 15330
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Appendix A. dithioloquinolinethiones as new potential multitargeted antibacterial and antifungal agents: Synthesis, biological evaluation and molecular docking studies

V. Kartsev, Khidmet S. Shikhaliev, A. Geronikaki, Svetlana M. Medvedeva, Irina V. Ledenyova, Mikhail Yu Krysin, A. Petrou, A. Ciric, J. Glamoclija and M. Sokovic

European Journal of Medicinal Chemistry, 2019, 175, 201
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Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

Honghua Zhang, Zhongjie Bai, Longqing Zhu, Yan Liang, Xiaohong Fan, Junfang Li, Huaixiu Wen, Tao Shi, Quanyi Zhao and Zhen Wang

European Journal of Medicinal Chemistry, 2020, 205, 112665
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Chemical Biology of H2S Signaling through Persulfidation

Milos R. Filipovic, Jasmina Zivanovic, Beatriz Alvarez and Ruma Banerjee

Chem. Rev., 2018, 118, 1253
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Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic, Emilia Kouroussis, Joshua B. Kohl, Bikash Adhikari, Biljana Bursac, Sonia Schott-Roux, Dunja Petrovic, Jan Lj. Miljkovic, Daniel Thomas-Lopez, Youngeun Jung, Marko Miler, Sarah Mitchell, Verica Milosevic, Jose Eduardo Gomes, Moran Benhar, Bruno Gonzalez-Zorn, Ivana Ivanovic-Burmazovic, Roberta Torregrossa, James R. Mitchell, Matthew Whiteman, Guenter Schwarz, Solomon H. Snyder, Bindu D. Paul, Kate S. Carroll and Milos R. Filipovic

Cell Metabolism, 2019, 30, 1152
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Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

Bartosz Szczesny, Michela Marcatti, John R. Zatarain, Nadiya Druzhyna, John E. Wiktorowicz, Péter Nagy, Mark R. Hellmich and Csaba Szabo

Sci Rep, 2016, 6
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Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Giuseppe Cirino, Csaba Szabo and Andreas Papapetropoulos

Physiological Reviews, 2023, 103, 31
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Esterase‐Responsive Mitochondria‐Targeted Hydropersulfide Donors Mitigate Doxorubicin Cardiotoxicity While Preserving Anticancer Activity

Jinjing Gu, Qi Liu, Deborah Rodriguez, Jordan Lamar, Klaire R. Bradley, Gizem Keceli, Andrew Thampoe, Yihang Xiao, Nazareno Paolocci, Vinayak S. Khodade and John P. Toscano

Angew Chem Int Ed, 2026, 65
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An off-the-shelf sensor for colourimetric detection of sulfide

Alexis Perry and Daniel Miles

Tetrahedron Letters, 2016, 57, 5788
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The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

Md. Aejazur Rahman, Joel N. Glasgow, Sajid Nadeem, Vineel P. Reddy, Ritesh R. Sevalkar, Jack R. Lancaster and Adrie J. C. Steyn

Front. Cell. Infect. Microbiol., 2020, 10
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Both the H 2 S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H 2 S donor AP39 exert protective effects in a mouse model of burn injury

Akbar Ahmad and Csaba Szabo

Pharmacological Research, 2016, 113, 348
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Targeted nanoparticles in mitochondrial medicine

Rakesh K. Pathak, Nagesh Kolishetti and Shanta Dhar

WIREs Nanomed Nanobiotechnol, 2015, 7, 315
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Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia–Reperfusion Injury via Specific Mitochondrial Actions

I. Lobb, J. Jiang, D. Lian, W. Liu, A. Haig, M.N. Saha, R. Torregrossa, M.E. Wood, M. Whiteman and A. Sener

American Journal of Transplantation, 2017, 17, 341
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Design and Development of a Bioorthogonal, Visualizable and Mitochondria‐Targeted Hydrogen Sulfide (H2S) Delivery System

Yinghan Chen, Ruohan Zhao, Cheng Tang, Chun Zhang, Wenyuan Xu, Luyan Wu, Yuqi Wang, Deju Ye and Yong Liang

Angew Chem Int Ed, 2022, 61
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Hydrogen sulfide signaling: interactions with nitric oxide and reactive oxygen species

John T. Hancock and Matthew Whiteman

Annals of the New York Academy of Sciences, 2016, 1365, 5
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Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity

Wei Feng, Xin-Yi Teo, Wisna Novera, Pondy Murugappan Ramanujulu, Dong Liang, Dejian Huang, Philip K. Moore, Lih-Wen Deng and Brian W. Dymock

J. Med. Chem., 2015, 58, 6456
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Hidrojen Sülfür’ün Fizyolojik ve Patolojik Olaylara Katkısı ve Klinikte Kullanımı

Kübra GÖNBE, Fatma AYDINOĞLU and Nuran ÖĞÜLENER

Arşiv Kaynak Tarama Dergisi, 2022, 31, 122
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The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

Dunja Petrovic, Emilia Kouroussis, Thibaut Vignane and Milos R. Filipovic

Front. Aging Neurosci., 2021, 13
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Hydrogen sulfide provides intestinal protection during a murine model of experimental necrotizing enterocolitis

Natalie A. Drucker, Amanda R. Jensen, Michael Ferkowicz and Troy A. Markel

Journal of Pediatric Surgery, 2018, 53, 1692
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Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion

Smriti Juriasingani, Aushanth Ruthirakanthan, Mahms Richard-Mohamed, Masoud Akbari, Shahid Aquil, Sanjay Patel, Rafid Al-Ogaili, Matthew Whiteman, Patrick Luke and Alp Sener

Biomolecules, 2021, 11, 446
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Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues

Yueqin Zheng, Bingchen Yu, Ladie Kimberly De La Cruz, Manjusha Roy Choudhury, Abiodun Anifowose and Binghe Wang

Medicinal Research Reviews, 2018, 38, 57
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Black gas, bright future: H2S based therapeutics for neurodegenerative disorders

Jordan L. Morris, Jordan J. Lee, Russell E. Morris and Jan Lj. Miljkovic

Neurotherapeutics, 2025, 22, e00755
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Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors

Andrea K. Steiger, Michela Marcatti, Csaba Szabo, Bartosz Szczesny and Michael D. Pluth

ACS Chem. Biol., 2017, 12, 2117
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A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition

Xian Zhang, Mengjie Ye, Yuxin Ge, Can Xiao, Keni Cui, Qidong You, Zhengyu Jiang and Xiaoke Guo

J. Med. Chem., 2024, 67, 19188
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International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

Csaba Szabo and Andreas Papapetropoulos

Pharmacological Reviews, 2017, 69, 497
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Hydrogen sulfide prodrugs—a review

Yueqin Zheng, Xingyue Ji, Kaili Ji and Binghe Wang

Acta Pharmaceutica Sinica B, 2015, 5, 367
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Synthesis of Phosphonium Enamines: Physicochemical Properties of Dimethylsulfoxide Solutions

S. A. Borodkin, E. A. Kazoyan, L. D. Popov, G. A. Shaginyan, A. R. Sarkisyan, I. N. Shcherbakov and Sh. A. Markaryan

Russ. J. Phys. Chem., 2019, 93, 2187
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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Jacek Zielonka, Joy Joseph, Adam Sikora, Micael Hardy, Olivier Ouari, Jeannette Vasquez-Vivar, Gang Cheng, Marcos Lopez and Balaraman Kalyanaraman

Chem. Rev., 2017, 117, 10043
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AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

Bartosz Szczesny, Katalin Módis, Kazunori Yanagi, Ciro Coletta, Sophie Le Trionnaire, Alexis Perry, Mark E. Wood, Matthew Whiteman and Csaba Szabo

Nitric Oxide, 2014, 41, 120
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Vasorelaxant Activity of AP39, a Mitochondria-Targeted H2S Donor, on Mouse Mesenteric Artery Rings In Vitro

Leonardo A. da Costa da Costa Marques, Simone A. Teixeira, Flávia N. de de Jesus, Mark E. Wood, Roberta Torregrossa, Matthew Whiteman, Soraia K. P. Costa and Marcelo N. Muscará

Biomolecules, 2022, 12, 280
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The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.

Katarzyna Magierowska, Dagmara Wójcik-Grzybek, Edyta Korbut, Dominik Bakalarz, Grzegorz Ginter, Aleksandra Danielak, Sławomir Kwiecień, Anna Chmura, Roberta Torregrossa, Matthew Whiteman and Marcin Magierowski

Redox Biology, 2023, 66, 102847
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Organelle-Targeted H2S Probes Enable Visualization of the Subcellular Distribution of H2S Donors

Leticia A. Montoya and Michael D. Pluth

Anal. Chem., 2016, 88, 5769
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Using mechanism-based combinations of H2S-donors to maximize the cardioprotective action of H2S

Stella Ravani, Athanasia Chatzianastasiou and Andreas Papapetropoulos

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 1853
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Esterase‐Responsive Mitochondria‐Targeted Hydropersulfide Donors Mitigate Doxorubicin Cardiotoxicity While Preserving Anticancer Activity

Jinjing Gu, Qi Liu, Deborah Rodriguez, Jordan Lamar, Klaire R. Bradley, Gizem Keceli, Andrew Thampoe, Yihang Xiao, Nazareno Paolocci, Vinayak S. Khodade and John P. Toscano

Angewandte Chemie, 2026, 138
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Precision Medicine

Alex M. Parker, Jarmon G. Lees, Andrew J. Murray, Anida Velagic, Shiang Y. Lim, Miles J. De Blasio and Rebecca H. Ritchie

JACC: Basic to Translational Science, 2025, 10, 101345
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Design and Development of a Bioorthogonal, Visualizable and Mitochondria‐Targeted Hydrogen Sulfide (H2S) Delivery System

Yinghan Chen, Ruohan Zhao, Cheng Tang, Chun Zhang, Wenyuan Xu, Luyan Wu, Yuqi Wang, Deju Ye and Yong Liang

Angewandte Chemie, 2022, 134
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Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2

Eva Latorre, Roberta Torregrossa, Mark E. Wood, Matthew Whiteman and Lorna W. Harries

Aging, 2018, 10, 1666
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Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

Vladimir F. Mironov, Andrey V. Nemtarev, Olga V. Tsepaeva, Mudaris N. Dimukhametov, Igor A. Litvinov, Alexandra D. Voloshina, Tatiana N. Pashirova, Eugenii A. Titov, Anna P. Lyubina, Syumbelya K. Amerhanova, Aidar T. Gubaidullin and Daut R. Islamov

Molecules, 2021, 26, 6350
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A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation?

George J. Dugbartey, Hjalmar R. Bouma, Manujendra N. Saha, Ian Lobb, Robert H. Henning and Alp Sener

Antioxidants & Redox Signaling, 2018, 28, 1503
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Organic Hydrogen Sulfide Donor Compounds with Cardioprotective Properties (Review)

N. I. Tkacheva, S. V. Morozov, B. B. Lomivorotov and I. A. Grigor’ev

Pharm Chem J, 2017, 51, 165
DOI: 10.1007/s11094-017-1576-5

Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola

H. Neale, N. Deshappriya, D. Arnold, M. E. Wood, M. Whiteman and J. T. Hancock

Eur J Plant Pathol, 2017, 149, 911
DOI: 10.1007/s10658-017-1240-7

Hydrogen sulfide: A novel nephroprotectant against cisplatin-induced renal toxicity

George J. Dugbartey, Hjalmar R. Bouma, Ian Lobb and Alp Sener

Nitric Oxide, 2016, 57, 15
DOI: 10.1016/j.niox.2016.04.005

Current Status and Future Prospects of Hydrogen Sulfide Donor‐Based Delivery Systems

Huangjie Lu, Yuying Chen and Ping Hu

Advanced Therapeutics, 2023, 6
DOI: 10.1002/adtp.202200349

The synthesis and antineoplastic activities of thiaziridine, sulfidometylphosphonium, and dithiaphosphitane‐sulfide against the Ehrlich ascites carcinoma

Shaimaa T. Mansour, Ahmed I. Hashem, Mansoura A. Abd‐El‐Maksoud, Marwa El‐Hussieny, Aida I. El‐Makawy, Sekena H. Abdel‐Aziem and Fouad M. Soliman

Fundamemntal Clinical Pharma, 2022, 36, 536
DOI: 10.1111/fcp.12751

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Rana Abdul Razzak, Gordon J. Florence and Frank J. Gunn-Moore

IJMS, 2019, 20, 3108
DOI: 10.3390/ijms20123108

CytochromecReduction by H2S Potentiates Sulfide Signaling

Victor Vitvitsky, Jan Lj. Miljkovic, Trever Bostelaar, Bikash Adhikari, Pramod K. Yadav, Andrea K. Steiger, Roberta Torregrossa, Michael D. Pluth, Matthew Whiteman, Ruma Banerjee and Milos R. Filipovic

ACS Chem. Biol., 2018, 13, 2300
DOI: 10.1021/acschembio.8b00463

2nd European Conference on the Biology of Hydrogen Sulfide, Exeter, England 8th–11th September 2013

Matt Whiteman and Christopher Kevil

Nitric Oxide, 2014, 41, 1
DOI: 10.1016/j.niox.2014.07.001

Multidimensional analysis of selected bioelements in rat's brain subjected to stroke procedure and treatment with H2S donor AP-39

Bartłomiej Rospond, Agata Krakowska, Joanna Piotrowska, Bartosz Pomierny, Weronika Krzyżanowska, Bernadeta Szewczyk, Przemysław Szafrański, Przemysław Dorożynski and Beata Paczosa-Bator

Journal of Trace Elements in Medicine and Biology, 2025, 88, 127628
DOI: 10.1016/j.jtemb.2025.127628

Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury

Katarzyna Magierowska, Edyta Korbut, Dagmara Wójcik-Grzybek, Dominik Bakalarz, Zbigniew Sliwowski, Jakub Cieszkowski, Małgorzata Szetela, Roberta Torregrossa, Matthew Whiteman and Marcin Magierowski

Journal of Controlled Release, 2022, 348, 321
DOI: 10.1016/j.jconrel.2022.05.051

Hydrogen Sulfide Signaling in Plants

Jingjing Huang and Yanjie Xie

Antioxidants & Redox Signaling, 2023, 39, 40
DOI: 10.1089/ars.2023.0267

AP39, a Mitochondria‐Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

Feng-li Zhao, Fang Fang, Pei-feng Qiao, Ning Yan, Dan Gao, Yong Yan and David Sebastián

Oxidative Medicine and Cellular Longevity, 2016, 2016
DOI: 10.1155/2016/8360738

Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathways

Aneta Stachowicz, Klaudia Czepiel, Anna Wiśniewska, Kamila Stachyra, Magdalena Ulatowska-Białas, Beata Kuśnierz-Cabala, Marcin Surmiak, Grzegorz Majka, Katarzyna Kuś, Mark E. Wood, Roberta Torregrossa, Matthew Whiteman and Rafał Olszanecki

Pharmacological Research, 2024, 209, 107428
DOI: 10.1016/j.phrs.2024.107428

The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia

Bartosz Pomierny, Weronika Krzyżanowska, Jakub Jurczyk, Alicja Skórkowska, Beata Strach, Małgorzata Szafarz, Katarzyna Przejczowska-Pomierny, Roberta Torregrossa, Matthew Whiteman, Monika Marcinkowska, Joanna Pera and Bogusława Budziszewska

IJMS, 2021, 22, 7816
DOI: 10.3390/ijms22157816

Intranasal Administrations of AP39-Loaded Liposomes Selectively Deliver H2S to Neuronal Mitochondria to Protect Neonatal Hypoxia–Ischemia by Targeting ERK1/2 and Caspase-1

Yan Song, Nianlu Li, Qian Luo, Dexiang Liu and Zhen Wang

ACS Biomater. Sci. Eng., 2025, 11, 1184
DOI: 10.1021/acsbiomaterials.4c02282

Neuroprotection by post-stroke administration of the slow-releasing hydrogen sulfide (H2S) donor AP39: Long-Term functional, MRI, and molecular evidence in a rodent stroke model

Pomierny Bartosz, Krzyżanowska Weronika, Skórkowska Alicja, Jurczyk Jakub, Przejczowska-Pomierny Katarzyna, Szafarz Małgorzata, Marcinkowska Monika, Guzda Zuzanna, Rachwał Patrycja, Kim Eugene, Mesquita Michel, Torregrossa Roberta, Whiteman Matthew, Pomierny-Chamioło Lucyna, Pera Joanna and Budziszewska Bogusława

European Journal of Pharmacology, 2025, 1008, 178331
DOI: 10.1016/j.ejphar.2025.178331

A Cell Trappable Methyl Rhodol‐Based Fluorescent Probe for Hydrogen Sulfide Detection

Kaylin G. Fosnacht, Matthew D. Hammers, Mary S. Earp, Annie K. Gilbert and Michael D. Pluth

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200426

Effect of hydrogen sulfide on glycolysis‐based energy production in mouse erythrocytes

Eden T. Wondimu, Quanxi Zhang, Zhuping Jin, Ming Fu, Roberta Torregrossa, Matthew Whiteman, Guangdong Yang, Lingyun Wu and Rui Wang

Journal Cellular Physiology, 2022, 237, 763
DOI: 10.1002/jcp.30544

Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice

S.A. Coavoy-Sánchez, L. Rodrigues, S.A. Teixeira, A.G. Soares, R. Torregrossa, M.E. Wood, M. Whiteman, S.K.P. Costa and M.N. Muscará

Pharmacological Research, 2016, 113, 686
DOI: 10.1016/j.phrs.2016.09.030

AP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury

George J. Dugbartey, Lucas N. Penney, Lauren Mills, Max Y. Zhang, Smriti Juriasingani, Sally Major, Patrick McLeod, Winnie Liu, Aaron Haig, Mark E. Wood, Roberta Torregrossa, Matthew Whiteman, Eva Turley, Carl Postenka and Alp Sener

Biomedicine & Pharmacotherapy, 2025, 183, 117869
DOI: 10.1016/j.biopha.2025.117869

Think of the Early Career Researchers! Saving the Oceans Through Collaborations

Mel Cosentino and Lucrecia Souviron-Priego

Front. Mar. Sci., 2021, 8
DOI: 10.3389/fmars.2021.574620

The role of H2S bioavailability in endothelial dysfunction

Rui Wang, Csaba Szabo, Fumito Ichinose, Asif Ahmed, Matthew Whiteman and Andreas Papapetropoulos

Trends in Pharmacological Sciences, 2015, 36, 568
DOI: 10.1016/j.tips.2015.05.007

Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury

Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley and Michael P. Murphy

Redox Biology, 2022, 55, 102429
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