Secondary metabolites of fungi from marine habitats

Mostafa E. Rateb and Rainer Ebel

Nat. Prod. Rep., 2011, 28, 290
DOI: 10.1039/c0np00061b

Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

Zhongshu Song, Walid Bakeer, James W. Marshall, Ahmed A. Yakasai, Rozida Mohd Khalid, Jerome Collemare, Elizabeth Skellam, Didier Tharreau, Marc-Henri Lebrun, Colin M. Lazarus, Andrew M. Bailey, Thomas J. Simpson and Russell J. Cox

Chem. Sci., 2015, 6, 4837
DOI: 10.1039/C4SC03707C

PKS and NRPS release mechanisms

Liangcheng Du and Lili Lou

Nat. Prod. Rep., 2010, 27, 255
DOI: 10.1039/B912037H

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

James F. Sanchez, Yi-Ming Chiang, Edyta Szewczyk, Ashley D. Davidson, Manmeet Ahuja, C. Elizabeth Oakley, Jin Woo Bok, Nancy Keller, Berl R. Oakley and Clay C. C. Wang

Mol. BioSyst., 2010, 6, 587
DOI: 10.1039/B904541D

The structures of type I polyketide synthases

Adrian T. Keatinge-Clay

Nat. Prod. Rep., 2012, 29, 1050
DOI: 10.1039/c2np20019h

In vitro studies of maleidride-forming enzymes

Sen Yin, Steffen Friedrich, Vjaceslavs Hrupins and Russell J. Cox

RSC Adv., 2021, 11, 14922
DOI: 10.1039/D1RA02118D

Secondary metabolites from entomopathogenic Hypocrealean fungi

István Molnár, Donna M. Gibson and Stuart B. Krasnoff

Nat. Prod. Rep., 2010, 27, 1241
DOI: 10.1039/c001459c

Lessons from the Synthetic Chemist Nature

Gerrit Jürjens, Andreas Kirschning and David A. Candito

Nat. Prod. Rep., 2015, 32, 723
DOI: 10.1039/C4NP00160E

In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase

Emma Liddle, Alan Scott, Li-Chen Han, David Ivison, Thomas J. Simpson, Christine L. Willis and Russell J. Cox

Chem. Commun., 2017, 53, 1727
DOI: 10.1039/C6CC10172K

Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

Katja M. Fisch, Elizabeth Skellam, David Ivison, Russell J. Cox, Andrew M. Bailey, Colin M. Lazarus and Thomas J. Simpson

Chem. Commun., 2010, 46, 5331
DOI: 10.1039/c0cc01162b

Michael additions in polyketide biosynthesis

Akimasa Miyanaga

Nat. Prod. Rep., 2019, 36, 531
DOI: 10.1039/C8NP00071A

Cupin-domain containing protein is not essential for the alkyl salicylaldehyde formation in Aspergillus ustus

Marlies Peter and Shu-Ming Li

Chem. Commun., 2024, 60, 11556
DOI: 10.1039/D4CC04227A

Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1

Huquan Gao, Weizhong Liu, Tianjiao Zhu, Xiaomei Mo, Attila Mándi, Tibor Kurtán, Jing Li, Jing Ai, Qianqun Gu and Dehai Li

Org. Biomol. Chem., 2012, 10, 9501
DOI: 10.1039/c2ob26757h

Meroterpenoids produced by fungi

Regina Geris and Thomas J. Simpson

Nat. Prod. Rep., 2009, 26, 1063
DOI: 10.1039/b820413f

The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides

Mary N. Heneghan, Ahmed A. Yakasai, Katherine Williams, Khomaizon A. Kadir, Zahida Wasil, Walid Bakeer, Katja M. Fisch, Andrew M. Bailey, Thomas J. Simpson, Russell J. Cox and Colin M. Lazarus

Chem. Sci., 2011, 2, 972
DOI: 10.1039/c1sc00023c

Biosynthetic studies of novel polyketides from the marine sponge-derived fungusStachylidiumsp. 293K04

Fayrouz El Maddah, Ekaterina Eguereva, Stefan Kehraus and Gabriele M. König

Org. Biomol. Chem., 2019, 17, 2747
DOI: 10.1039/C9OB00198K

Reengineering the programming of a functional domain of an iterative highly reducing polyketide synthase

Oliver Piech and Russell J. Cox

RSC Adv., 2020, 10, 18469
DOI: 10.1039/D0RA04026F

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Katherine Williams, Agnieszka J. Szwalbe, Claire Dickson, Tim R. Desson, Nicholas P. Mulholland, Jason L. Vincent, John M. Clough, Andrew M. Bailey, Craig P. Butts, Christine L. Willis, Thomas J. Simpson and Russell J. Cox

Chem. Commun., 2017, 53, 7965
DOI: 10.1039/C7CC03303F

Molecular methods unravel the biosynthetic potential of Trichoderma species

Mary L. Shenouda and Russell J. Cox

RSC Adv., 2021, 11, 3622
DOI: 10.1039/D0RA09627J

Fungal type III polyketide synthases

Makoto Hashimoto, Takamasa Nonaka and Isao Fujii

Nat. Prod. Rep., 2014, 31, 1306
DOI: 10.1039/C4NP00096J

First total synthesis of versicotide A, B and C

Laura Posada, Danilo Davyt and Gloria Serra

RSC Adv., 2020, 10, 43653
DOI: 10.1039/D0RA09635K

C-Methylation controls the biosynthetic programming of alternapyrone

Jaiyfungkhong Phakeovilay, Witcha Imaram, Supachai Vuttipongchaikij, Waraporn Bunnak, Colin M. Lazarus and Pakorn Wattana-Amorn

Org. Biomol. Chem., 2022, 20, 5050
DOI: 10.1039/D2OB00947A

Aflatoxin and deconstruction of type I, iterative polyketide synthase function

Craig A. Townsend

Nat. Prod. Rep., 2014, 31, 1260
DOI: 10.1039/C4NP00092G

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues

B. Bonsch, V. Belt, C. Bartel, N. Duensing, M. Koziol, C. M. Lazarus, A. M. Bailey, T. J. Simpson and R. J. Cox

Chem. Commun., 2016, 52, 6777
DOI: 10.1039/C6CC02130A

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

Russell J. Cox

Nat. Prod. Rep., 2023, 40, 9
DOI: 10.1039/D2NP00007E

The chemistry and biology of cytochalasans

Kirstin Scherlach, Daniela Boettger, Nicole Remme and Christian Hertweck

Nat. Prod. Rep., 2010, 27, 869
DOI: 10.1039/b903913a

Investigation of chain-length selection by the tenellin iterative highly-reducing polyketide synthase

Katharina Schmidt and Russell J. Cox

RSC Adv., 2024, 14, 8963
DOI: 10.1039/D3RA08463A

Intramolecular cyclizations of polyketide biosynthesis: mining for a “Diels–Alderase”?

Wendy L. Kelly

Org. Biomol. Chem., 2008, 6, 4483
DOI: 10.1039/b814552k

Talaroketals A and B, unusual bis(oxaphenalenone) spiro and fused ketals from the soil fungus Talaromyces stipitatus ATCC 10500

Yi Zang, Grégory Genta-Jouve, Pascal Retailleau, Alexandre Escargueil, Stéphane Mann, Bastien Nay and Soizic Prado

Org. Biomol. Chem., 2016, 14, 2691
DOI: 10.1039/C5OB02657A

Delineating Monascus azaphilone pigment biosynthesis: oxidoreductive modifications determine the ring cyclization pattern in azaphilone biosynthesis

Balakrishnan Bijinu, Jae-Won Suh, Si-Hyung Park and Hyung-Jin Kwon

RSC Adv., 2014, 4, 59405
DOI: 10.1039/C4RA11713A

Cyclization of aromatic polyketides from bacteria and fungi

Hui Zhou, Yanran Li and Yi Tang

Nat. Prod. Rep., 2010, 27, 839
DOI: 10.1039/b911518h

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Xiao-Long Yang, Steffen Friedrich, Sen Yin, Oliver Piech, Katherine Williams, Thomas J. Simpson and Russell J. Cox

Chem. Sci., 2019, 10, 8478
DOI: 10.1039/C9SC03173A

Investigations into the biosynthesis of the antifungal strobilurins

Zafar Iqbal, Li-Chen Han, Anna M. Soares-Sello, Risa Nofiani, Gerald Thormann, Axel Zeeck, Russell J. Cox, Christine L. Willis and Thomas J. Simpson

Org. Biomol. Chem., 2018, 16, 5524
DOI: 10.1039/C8OB00608C

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi

Claudio Greco, Kate de Mattos-Shipley, Andrew M. Bailey, Nicholas P. Mulholland, Jason L. Vincent, Christine L. Willis, Russell J. Cox and Thomas J. Simpson

Chem. Sci., 2019, 10, 2930
DOI: 10.1039/C8SC05126G

Biochemical dissection of a fungal highly reducing polyketide synthase condensing region reveals basis for acyl group selection

Mia E. Foran, Nazia B. Auckloo, Y. T. Candace Ho, Shaonan Liu, Yang Hai and Matthew Jenner

Chem. Sci., 2025, 16, 13173
DOI: 10.1039/D5SC01027F

Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS

Katja Maria Fisch

RSC Adv., 2013, 3, 18228
DOI: 10.1039/c3ra42661k

Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds

Xu-Wen Li, Alexandre Ear and Bastien Nay

Nat. Prod. Rep., 2013, 30, 765
DOI: 10.1039/c3np70016j

The structural role of the carrier protein – active controller or passive carrier

John Crosby and Matthew P. Crump

Nat. Prod. Rep., 2012, 29, 1111
DOI: 10.1039/c2np20062g

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

Andrew M. Bailey, Russell J. Cox, Kate Harley, Colin M. Lazarus, Thomas J. Simpson and Elizabeth Skellam

Chem. Commun., 2007, 4053
DOI: 10.1039/b708614h

Isocoumarin formation by heterologous gene expression and modification by host enzymes

Pan Xiang, Lena Ludwig-Radtke, Wen-Bing Yin and Shu-Ming Li

Org. Biomol. Chem., 2020, 18, 4946
DOI: 10.1039/D0OB00989J

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

Markus Gressler, Nikolai A. Löhr, Tim Schäfer, Stefanie Lawrinowitz, Paula Sophie Seibold and Dirk Hoffmeister

Nat. Prod. Rep., 2021, 38, 702
DOI: 10.1039/D0NP00077A

Fungal polyketide biosynthesis – a personal perspective

Thomas J. Simpson

Nat. Prod. Rep., 2014, 31, 1247
DOI: 10.1039/C4NP00065J

The molecular steps of citrinin biosynthesis in fungi

Yi He and Russell J. Cox

Chem. Sci., 2016, 7, 2119
DOI: 10.1039/C5SC04027B

Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimatemetabolite production, and PKS genes

Elfie Stocker-Wörgötter

Nat. Prod. Rep., 2008, 25, 188
DOI: 10.1039/B606983P

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

Chen-Yu Chiang, Masao Ohashi and Yi Tang

Nat. Prod. Rep., 2023, 40, 89
DOI: 10.1039/D2NP00050D

The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies

Andrew M. Harned and Kelly A. Volp

Nat. Prod. Rep., 2011, 28, 1790
DOI: 10.1039/c1np00039j

Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430

Lu Wang, Yanbing Huang, Liping Zhang, Zhiwen Liu, Wei Liu, Huixin Xu, Qingbo Zhang, Haibo Zhang, Yan Yan, Zhiyong Liu, Tianyu Zhang, Wenjun Zhang and Changsheng Zhang

Org. Biomol. Chem., 2021, 19, 6030
DOI: 10.1039/D1OB00869B

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

Jialiang Wang, Zixin Deng, Jingdan Liang and Zhijun Wang

Nat. Prod. Rep., 2023, 40, 1498
DOI: 10.1039/D3NP00015J

Chemical probing of thiotetronate bio-assembly

Judith Havemann, Marie E. Yurkovich, Robert Jenkins, Sophia Harringer, Weixin Tao, Shishi Wen, Yuhui Sun, Peter F. Leadlay and Manuela Tosin

Chem. Commun., 2017, 53, 1912
DOI: 10.1039/C6CC09933E

Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

Elizabeth J. Skellam, Deirdre Hurley, Jack Davison, Colin M. Lazarus, Thomas J. Simpson and Russell J. Cox

Mol. BioSyst., 2010, 6, 680
DOI: 10.1039/b923990a

Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

Francesco Trenti, Karen E. Lebe, Emilie Adelin, Jamal Ouazzani, Carsten Schotte and Russell J. Cox

RSC Adv., 2020, 10, 27369
DOI: 10.1039/D0RA05311B

The architectures of iterative type I PKS and FAS

Dominik A. Herbst, Craig A. Townsend and Timm Maier

Nat. Prod. Rep., 2018, 35, 1046
DOI: 10.1039/C8NP00039E

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Douglas M. Roberts, Christoph Bartel, Alan Scott, David Ivison, Thomas J. Simpson and Russell J. Cox

Chem. Sci., 2017, 8, 1116
DOI: 10.1039/C6SC03496A

A photocrosslinking assay for reporting protein interactions in polyketide and fatty acid synthases

Zhixia Ye, Morgan Bair, Hemant Desai and Gavin J. Williams

Mol. BioSyst., 2011, 7, 3152
DOI: 10.1039/c1mb05270e

Resorcylic acid lactones (RALs) and their structural congeners: recent advances in their biosynthesis, chemical synthesis and biology

Nandan Jana and Samik Nanda

New J. Chem., 2018, 42, 17803
DOI: 10.1039/C8NJ02534G

Preliminary kinetic analysis of acyl carrier protein–ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase

Pedro Beltran-Alvarez, Christopher J. Arthur, Russell J. Cox, John Crosby, Matthew P. Crump and Thomas J. Simpson

Mol. BioSyst., 2009, 5, 511
DOI: 10.1039/b821844g

One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity

Zahida Wasil, Khomaizon A. K. Pahirulzaman, Craig Butts, Thomas J. Simpson, Colin M. Lazarus and Russell J. Cox

Chem. Sci., 2013, 4, 3845
DOI: 10.1039/c3sc51785c

Complexity and simplicity in the biosynthesis of enediyne natural products

Zhao-Xun Liang

Nat. Prod. Rep., 2010, 27, 499
DOI: 10.1039/b908165h

Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sediment-sourced fungus Chaetomium globosum SD-347

Xiao-Dong Li, Xiao-Ming Li, Bin-Gui Wang and Xin Li

Org. Biomol. Chem., 2024, 22, 3979
DOI: 10.1039/D4OB00449C

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint

John C. Vederas

Nat. Prod. Rep., 2014, 31, 1253
DOI: 10.1039/C4NP00091A

Fungal benzene carbaldehydes: occurrence, structural diversity, activities and biosynthesis

Huomiao Ran and Shu-Ming Li

Nat. Prod. Rep., 2021, 38, 240
DOI: 10.1039/D0NP00026D

Synthetic biology routes to new and extinct natural products

Thomas J. Simpson

RSC Chem. Biol., 2025, 6, 721
DOI: 10.1039/D5CB00047E

Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans

James F. Sanchez, Ruth Entwistle, David Corcoran, Berl R. Oakley and Clay C. C. Wang

Med. Chem. Commun., 2012, 3, 997
DOI: 10.1039/c2md20055d

Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain

Ishin Soehano, Lifeng Yang, Feiqing Ding, Huihua Sun, Zhen Jie Low, Xuewei Liu and Zhao-Xun Liang

Org. Biomol. Chem., 2014, 12, 8542
DOI: 10.1039/C4OB01777C

Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase

Hirokazu Kage, Elena Riva, James S. Parascandolo, Martin F. Kreutzer, Manuela Tosin and Markus Nett

Org. Biomol. Chem., 2015, 13, 11414
DOI: 10.1039/C5OB02009C

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis

Ahmed al Fahad, Amira Abood, Katja M. Fisch, Anna Osipow, Jack Davison, Marija Avramović, Craig P. Butts, Jörn Piel, Thomas J. Simpson and Russell J. Cox

Chem. Sci., 2014, 5, 523
DOI: 10.1039/C3SC52911H

Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

Faviola Cardoso-Martínez, José M. de la Rosa, Ana R. Díaz-Marrero, José Darias, Claudia Cerella, Marc Diederich and Mercedes Cueto

Org. Biomol. Chem., 2015, 13, 7248
DOI: 10.1039/C5OB00773A

The Ketosynthase Domain Controls Chain Length in Mushroom Oligocyclic Polyketide Synthases

Nikolai A. Löhr, Maximilian C. Urban, Frederic Eisen, Lukas Platz, Wolfgang Hüttel, Markus Gressler, Michael Müller and Dirk Hoffmeister

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202200649

The Distant Siblings—A Phylogenomic Roadmap Illuminates the Origins of Extant Diversity in Fungal Aromatic Polyketide Biosynthesis

Grzegorz Koczyk, Adam Dawidziuk and Delfina Popiel

Genome Biol Evol, 2015, 7, 3132
DOI: 10.1093/gbe/evv204

Starter Unit Flexibility for Engineered Product Synthesis by the Nonreducing Polyketide Synthase PksA

Callie R. Huitt-Roehl, Eric A. Hill, Martina M. Adams, Anna L. Vagstad, Jesse W. Li and Craig A. Townsend

ACS Chem. Biol., 2015, 10, 1443
DOI: 10.1021/acschembio.5b00005

Genomic and chromatographic approach for the discovery of polyketide antimicrobial metabolites from an endophyticPhomopsis liquidambarisCBR-18

H.C. Yashavantha Rao and Sreedharamurthy Satish

Frontiers in Life Science, 2015, 8, 200
DOI: 10.1080/21553769.2015.1033768

Anatomy of a Fungal Polyketide Synthase

Kira J. Weissman

Science, 2008, 320, 186
DOI: 10.1126/science.1157677

A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins inFusarium verticillioides

Ryan Gerber, Lili Lou and Liangcheng Du

J. Am. Chem. Soc., 2009, 131, 3148
DOI: 10.1021/ja8091054

Functional Complementation of Fumonisin Biosynthesis in FUM1-Disrupted Fusarium verticillioides by the AAL-Toxin Polyketide Synthase Gene ALT1 from Alternaria alternata f. sp. Lycopersici

Xiangcheng Zhu, Chad Vogeler and Liangcheng Du

J. Nat. Prod., 2008, 71, 957
DOI: 10.1021/np8000514

Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application

Ying Yin, Menghao Cai, Xiangshan Zhou, Zhiyong Li and Yuanxing Zhang

Appl Microbiol Biotechnol, 2016, 100, 7787
DOI: 10.1007/s00253-016-7733-z

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

Hans-Wilhelm Nützmann, Yazmid Reyes-Dominguez, Kirstin Scherlach, Volker Schroeckh, Fabian Horn, Agnieszka Gacek, Julia Schümann, Christian Hertweck, Joseph Strauss and Axel A. Brakhage

Proc. Natl. Acad. Sci. U.S.A., 2011, 108, 14282
DOI: 10.1073/pnas.1103523108

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

Yit-Heng Chooi and Yi Tang

J. Org. Chem., 2012, 77, 9933
DOI: 10.1021/jo301592k

An In Planta -Expressed Polyketide Synthase Produces ( R )-Mellein in the Wheat Pathogen Parastagonospora nodorum

Yit-Heng Chooi, Christian Krill, Russell A. Barrow, Shasha Chen, Robert Trengove, Richard P. Oliver, Peter S. Solomon and A. A. Brakhage

Appl Environ Microbiol, 2015, 81, 177
DOI: 10.1128/AEM.02745-14

Uncovering Lasonolide A Biosynthesis Using Genome-Resolved Metagenomics

Siddharth Uppal, Jackie L. Metz, René K. M. Xavier, Keshav Kumar Nepal, Dongbo Xu, Guojun Wang, Jason C. Kwan and Jacques Ravel

mBio, 2022, 13
DOI: 10.1128/mbio.01524-22

CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

Tomas Strucko, Line Due Buron, Zofia Dorota Jarczynska, Christina Spuur Nødvig, Louise Mølgaard, Barbara Ann Halkier and Uffe Hasbro Mortensen

Sci Rep, 2017, 7
DOI: 10.1038/srep41431

High Diversity of Type I Polyketide Genes in Bacidia rubella as Revealed by the Comparative Analysis of 23 Lichen Genomes

Julia V. Gerasimova, Andreas Beck, Silke Werth and Philipp Resl

JoF, 2022, 8, 449
DOI: 10.3390/jof8050449

Characterization of the Biosynthetic Genes for 10,11-Dehydrocurvularin, a Heat Shock Response-Modulating Anticancer Fungal Polyketide from Aspergillus terreus

Yuquan Xu, Patricia Espinosa-Artiles, Vivien Schubert, Ya-ming Xu, Wei Zhang, Min Lin, A. A. Leslie Gunatilaka, Roderich Sï¿½ssmuth and Istvï¿½n Molnï¿½r

Appl Environ Microbiol, 2013, 79, 2038
DOI: 10.1128/AEM.03334-12

Versatility of polyketide synthases in generating metabolic diversity

Rajesh S Gokhale, Rajan Sankaranarayanan and Debasisa Mohanty

Current Opinion in Structural Biology, 2007, 17, 736
DOI: 10.1016/j.sbi.2007.08.021

New insights into the formation of fungal aromatic polyketides

Jason M. Crawford and Craig A. Townsend

Nat Rev Microbiol, 2010, 8, 879
DOI: 10.1038/nrmicro2465

Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis

Chong Wai Liew, Martina Nilsson, Ming Wei Chen, Huihua Sun, Tobias Cornvik, Zhao-Xun Liang and Julien Lescar

Journal of Biological Chemistry, 2012, 287, 23203
DOI: 10.1074/jbc.M112.362210

Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi

Man-Cheng Tang, Curt R. Fischer, Jason V. Chari, Dan Tan, Sundari Suresh, Angela Chu, Molly Miranda, Justin Smith, Zhuan Zhang, Neil K. Garg, Robert P. St. Onge and Yi Tang

J. Am. Chem. Soc., 2019, 141, 8198
DOI: 10.1021/jacs.9b01083

Fumopyrones A-D, four new α-pyrone derivatives from cultures of the basidiomycete Neofomitella fumosipora

Haiqi Li, Jing Hu, Xiaoqing Li, Yao Qin, Mingda Yao, Jiaojiao Wang, Yungeng Gao and Yan-Long Yang

Phytochemistry Letters, 2025, 69, 103025
DOI: 10.1016/j.phytol.2025.103025

Subcellular localization of fungal specialized metabolites

Elizabeth Skellam

Fungal Biol Biotechnol, 2022, 9
DOI: 10.1186/s40694-022-00140-z

Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway

Kejing Tao, Lin Du, Xueqian Sun, Menghao Cai, Tianjiao Zhu, Xiangshan Zhou, Qianqun Gu and Yuanxing Zhang

Tetrahedron Letters, 2009, 50, 1082
DOI: 10.1016/j.tetlet.2008.12.094

Isolation and expression of two polyketide synthase genes from Trichoderma harzianum 88 during mycoparasitism

Lin Yao, Chong Tan, Jinzhu Song, Qian Yang, Lijie Yu and Xinling Li

Brazilian Journal of Microbiology, 2016, 47, 468
DOI: 10.1016/j.bjm.2016.01.004

Cloning and heterologous transcription of a polyketide synthase gene from the lichen Solorina crocea

Andrey N. Gagunashvili, Snorri P. Davíðsson, Zophonías O. Jónsson and Ólafur S. Andrésson

Mycological Research, 2009, 113, 354
DOI: 10.1016/j.mycres.2008.11.011

Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase

Ahmed A. Yakasai, Jack Davison, Zahida Wasil, Laura M. Halo, Craig P. Butts, Colin M. Lazarus, Andrew M. Bailey, Thomas J. Simpson and Russell J. Cox

J. Am. Chem. Soc., 2011, 133, 10990
DOI: 10.1021/ja204200x

Polyketides, Proteins and Genes in Fungi: Programmed Nano‐Machines Begin to Reveal Their Genes

Russel J. Cox

ChemInform, 2007, 38
DOI: 10.1002/chin.200740268

Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster

Bijinu Balakrishnan, Suman Karki, Shih-Hau Chiu, Hyun-Ju Kim, Jae-Won Suh, Bora Nam, Yeo-Min Yoon, Chien-Chi Chen and Hyung-Jin Kwon

Appl Microbiol Biotechnol, 2013, 97, 6337
DOI: 10.1007/s00253-013-4745-9

The Diversity of Polyketide Synthase Genes from Sugarcane-Derived Fungi

Juan Diego Rojas, Lara Durães Sette, Welington L. de Araujo, Mateus Schreiner Garcez Lopes, Luiziana Ferreira da Silva, Renata L. A. Furlan and Gabriel Padilla

Microb Ecol, 2012, 63, 565
DOI: 10.1007/s00248-011-9938-0

Combinatorial biosynthesis for the engineering of novel fungal natural products

Elizabeth Skellam, Sanjeevan Rajendran and Lei Li

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01172-9

Genome mining approach for harnessing the cryptic gene cluster in Alternaria solani: production of PKS–NRPS hybrid metabolite, didymellamide B

Takahiro Ugai, Atsushi Minami, Katsuya Gomi and Hideaki Oikawa

Tetrahedron Letters, 2016, 57, 2793
DOI: 10.1016/j.tetlet.2016.05.043

Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Atsushi Minami, Takahiro Ugai, Taro Ozaki and Hideaki Oikawa

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-70177-w

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

Yit-Heng Chooi, Ralph Cacho and Yi Tang

Chemistry & Biology, 2010, 17, 483
DOI: 10.1016/j.chembiol.2010.03.015

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

Manmeet Ahuja, Yi-Ming Chiang, Shu-Lin Chang, Mike B. Praseuth, Ruth Entwistle, James F. Sanchez, Hsien-Chun Lo, Hsu-Hua Yeh, Berl R. Oakley and Clay C. C. Wang

J. Am. Chem. Soc., 2012, 134, 8212
DOI: 10.1021/ja3016395

Rational reprogramming of fungal polyketide first-ring cyclization

Yuquan Xu, Tong Zhou, Zhengfu Zhou, Shiyou Su, Sue A. Roberts, William R. Montfort, Jia Zeng, Ming Chen, Wei Zhang, Min Lin, Jixun Zhan and István Molnár

Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 5398
DOI: 10.1073/pnas.1301201110

Isolation and characterization of a non-reducing polyketide synthase gene in Cladonia macilenta

Min-Hye Jeong, Jung A Kim, Nan Hee Yu, Jae Sung Jung, Soon Gyu Hong, Yong Hwa Cheong and Jae-Seoun Hur

Mycoscience, 2015, 56, 49
DOI: 10.1016/j.myc.2014.03.001

Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

Xiao‐Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto and Ikuro Abe

ChemBioChem, 2014, 15, 1578
DOI: 10.1002/cbic.201402172

Biosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae

Anna K. Atanasoff-Kardjalieff, Friederike Lünne, Svetlana Kalinina, Joseph Strauss, Hans-Ulrich Humpf and Lena Studt

Front. Fungal Biol., 2021, 2
DOI: 10.3389/ffunb.2021.671796

The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid

Ahmed al Fahad, Amira Abood, Thomas J. Simpson and Russell J. Cox

Angewandte Chemie, 2014, 126, 7649
DOI: 10.1002/ange.201403450

Investigation of the Biosynthetic Potential of Endophytes in Traditional Chinese Anticancer Herbs

Kristin I. Miller, Chen Qing, Daniel Man Yuen Sze, Brett A. Neilan and William C. S. Cho

PLoS ONE, 2012, 7, e35953
DOI: 10.1371/journal.pone.0035953

Engineering polyketide synthases and nonribosomal peptide synthetases

Gavin J Williams

Current Opinion in Structural Biology, 2013, 23, 603
DOI: 10.1016/j.sbi.2013.06.012

Cloning and sequence characterization of a non-reducing polyketide synthase gene from the lichen Xanthoparmelia semiviridis

Yit-Heng Chooi, David M. Stalker, Meryl A. Davis, Isao Fujii, John A. Elix, Simone H.J.J. Louwhoff and Ann C. Lawrie

Mycological Research, 2008, 112, 147
DOI: 10.1016/j.mycres.2007.08.022

Bioactive Bianthraquinones and Meroterpenoids from a Marine-Derived Stemphylium sp. Fungus

Ji-Yeon Hwang, Sung Chul Park, Woong Sub Byun, Dong-Chan Oh, Sang Kook Lee, Ki-Bong Oh and Jongheon Shin

Marine Drugs, 2020, 18, 436
DOI: 10.3390/md18090436

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

Ralph A. Cacho, Yi Tang and Yit-Heng Chooi

Front. Microbiol., 2015, 5
DOI: 10.3389/fmicb.2014.00774

Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma

Scott E. Baker, Giancarlo Perrone, Nathan M. Richardson, Antonia Gallo and Christian P. Kubicek

Microbiology, 2012, 158, 147
DOI: 10.1099/mic.0.053462-0

Endophytic fungi from Passiflora incarnata: an antioxidant compound source

Matheus Henrique Reis da Silva, Luis Gabriel Cueva-Yesquén, Sinésio Boaventura Júnior, Vera Lucia Garcia, Adilson Sartoratto, Dejanira de Franceschi de Angelis and Derlene Attili de Angelis

Arch Microbiol, 2020, 202, 2779
DOI: 10.1007/s00203-020-02001-y

Improving free, conjugated, and bound phenolic fractions in fermented oats (Avena sativa L.) with Monascus anka and their antioxidant activity

Qi Bei, Yan Liu, Lu Wang, Gong Chen and Zhenqiang Wu

Journal of Functional Foods, 2017, 32, 185
DOI: 10.1016/j.jff.2017.02.028

Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin

Maria Cristina Stroe, Tina Netzker, Kirstin Scherlach, Thomas Krüger, Christian Hertweck, Vito Valiante and Axel A Brakhage

eLife, 2020, 9
DOI: 10.7554/eLife.52541

Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase

Yanran Li, Yit-Heng Chooi, Yuewei Sheng, Joan S. Valentine and Yi Tang

J. Am. Chem. Soc., 2011, 133, 15773
DOI: 10.1021/ja206906d

Molecular and Chemical Characterization of the Biosynthesis of the 6-MSA-Derived Meroterpenoid Yanuthone D in Aspergillus niger

Dorte K. Holm, Lene M. Petersen, Andreas Klitgaard, Peter B. Knudsen, Zofia D. Jarczynska, Kristian F. Nielsen, Charlotte H. Gotfredsen, Thomas O. Larsen and Uffe H. Mortensen

Chemistry & Biology, 2014, 21, 519
DOI: 10.1016/j.chembiol.2014.01.013

Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

Xue-Mei Hou, Ya-Hui Zhang, Yang Hai, Ji-Yong Zheng, Yu-Cheng Gu, Chang-Yun Wang and Chang-Lun Shao

Marine Drugs, 2017, 15, 363
DOI: 10.3390/md15110363

Culture studies on the mycobiont isolated from Parmotrema reticulatum (Taylor) Choisy: metabolite production under different conditions

Alejandra T. Fazio, María D. Bertoni, Mónica T. Adler, Laura B. Ruiz, María L. Rosso, Lucia Muggia, Armin Hager, Elfie Stocker-Wörgötter and Marta S. Maier

Mycol Progress, 2009, 8, 359
DOI: 10.1007/s11557-009-0609-1

Evolutionary Imprint of Catalytic Domains in Fungal PKS–NRPS Hybrids

Daniela Boettger, Holger Bergmann, Barbara Kuehn, Ekaterina Shelest and Christian Hertweck

ChemBioChem, 2012, 13, 2363
DOI: 10.1002/cbic.201200449

Resorcylic Acid Lactone Biosynthesis Relies on a Stereotolerant Macrocyclizing Thioesterase

Graham W. Heberlig, Monica Wirz, Meng Wang and Christopher N. Boddy

Org. Lett., 2014, 16, 5858
DOI: 10.1021/ol502747t

Differential Retention and Loss of a Mycotoxin in Fungal Evolution

Lin Chen, Ziying Yan, Bolei Yang, Bowen Tai, Weizhao Li, Erfeng Li, Gang Wang and Fuguo Xing

Toxins, 2025, 17, 311
DOI: 10.3390/toxins17060311

Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

Angelica O. Zabala, Yit-Heng Chooi, Moon Seok Choi, Hsiao-Ching Lin and Yi Tang

ACS Chem. Biol., 2014, 9, 1576
DOI: 10.1021/cb500284t

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria

Haotong Chen and Liangcheng Du

Appl Microbiol Biotechnol, 2016, 100, 541
DOI: 10.1007/s00253-015-7093-0

De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model Organism for Fungal Morphogenesis

Minou Nowrousian, Jason E. Stajich, Meiling Chu, Ines Engh, Eric Espagne, Karen Halliday, Jens Kamerewerd, Frank Kempken, Birgit Knab, Hsiao-Che Kuo, Heinz D. Osiewacz, Stefanie Pöggeler, Nick D. Read, Stephan Seiler, Kristina M. Smith, Denise Zickler, Ulrich Kück, Michael Freitag and Paul M. Richardson

PLoS Genet, 2010, 6, e1000891
DOI: 10.1371/journal.pgen.1000891

Condensation of Macrocyclic Polyketides Produced byPenicilliumsp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway

Marcos V. de Castro, Laura P. Ióca, David E. Williams, Bruna Z. Costa, Carolina M. Mizuno, Mario F. C. Santos, Karen de Jesus, Éverton L. F. Ferreira, Mirna H. R. Seleghim, Lara D. Sette, Edenir R. Pereira Filho, Antonio G. Ferreira, Natália S. Gonçalves, Raquel A. Santos, Brian O. Patrick, Raymond J. Andersen and Roberto G. S. Berlinck

J. Nat. Prod., 2016, 79, 1668
DOI: 10.1021/acs.jnatprod.6b00295

Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

Scott Griffiths, Carl H. Mesarich, Benedetta Saccomanno, Abraham Vaisberg, Pierre J. G. M. De Wit, Russell Cox and Jérôme Collemare

Proc. Natl. Acad. Sci. U.S.A., 2016, 113, 6851
DOI: 10.1073/pnas.1603528113

An Iterative Type I Polyketide Synthase Initiates the Biosynthesis of the Antimycoplasma Agent Micacocidin

Hirokazu Kage, Martin F. Kreutzer, Barbara Wackler, Dirk Hoffmeister and Markus Nett

Chemistry & Biology, 2013, 20, 764
DOI: 10.1016/j.chembiol.2013.04.010

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

Suzanne M. Ma, Jesse W.-H. Li, Jin W. Choi, Hui Zhou, K. K. Michael Lee, Vijayalakshmi A. Moorthie, Xinkai Xie, James T. Kealey, Nancy A. Da Silva, John C. Vederas and Yi Tang

Science, 2009, 326, 589
DOI: 10.1126/science.1175602

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases

Gerald Lackner, Mathias Misiek, Jana Braesel and Dirk Hoffmeister

Fungal Genetics and Biology, 2012, 49, 996
DOI: 10.1016/j.fgb.2012.09.009

Bioinformatics Prediction of Polyketide Synthase Gene Clusters from Mycosphaerella fijiensis

Roslyn D. Noar, Margaret E. Daub and Minou Nowrousian

PLoS ONE, 2016, 11, e0158471
DOI: 10.1371/journal.pone.0158471

Biochemistry‐Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides

Junya Takino, Akari Kotani, Taro Ozaki, Wenquan Peng, Jie Yu, Yian Guo, Susumu Mochizuki, Kazuya Akimitsu, Masaru Hashimoto, Tao Ye, Atsushi Minami and Hideaki Oikawa

Angewandte Chemie, 2021, 133, 23591
DOI: 10.1002/ange.202110658

Functional analysis of fungal polyketide biosynthesis genes

Isao Fujii

J Antibiot, 2010, 63, 207
DOI: 10.1038/ja.2010.17

Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

Yi Zang, Grégory Genta-Jouve, Alexandre E. Escargueil, Annette K. Larsen, Laura Guedon, Bastien Nay and Soizic Prado

J. Nat. Prod., 2016, 79, 2991
DOI: 10.1021/acs.jnatprod.6b00458

Antibiosis functions during interactions of Trichoderma afroharzianum and Trichoderma gamsii with plant pathogenic Rhizoctonia and Pythium

Xinjian Zhang, Paul R. Harvey, Belinda E. Stummer, Rosemary A. Warren, Guangzhi Zhang, Kai Guo, Jishun Li and Hetong Yang

Funct Integr Genomics, 2015, 15, 599
DOI: 10.1007/s10142-015-0456-x

Structures and Biosynthesis of the Pyridinopyrones, Polyenepyrones from a Marine-Derived Streptomyces Species

Takashi Fukuda, Eric D. Miller, Benjamin R. Clark, Ali Alnauman, Cormac D. Murphy, Paul R. Jensen and William Fenical

J. Nat. Prod., 2011, 74, 1773
DOI: 10.1021/np200323e

Concise Biosynthesis of Phenylfuropyridones in Fungi

Zhuan Zhang, Tianzhang Qiao, Kenji Watanabe and Yi Tang

Angewandte Chemie, 2020, 132, 20061
DOI: 10.1002/ange.202008321

The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia

Andrea N. L. Batista, José Roberto A. dos Santos-Pinto, João M. Batista, Tatiana M. Souza-Moreira, Mariana M. Santoni, Cleslei F. Zanelli, Massuo J. Kato, Silvia N. López, Mario S. Palma and Maysa Furlan

J. Nat. Prod., 2017, 80, 1275
DOI: 10.1021/acs.jnatprod.6b00827

Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone

Daniele Armaleo, Xiameng Sun and Chicita Culberson

Mycologia, 2011, 103, 741
DOI: 10.3852/10-335

Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach

Pierluigi Reveglia, Francisco J. Agudo-Jurado, Eleonora Barilli, Marco Masi, Antonio Evidente and Diego Rubiales

JoF, 2023, 9, 610
DOI: 10.3390/jof9060610

Bacillus cereus sensu lato antimicrobial arsenal: An overview

Louis Morandini, Simon Caulier, Claude Bragard and Jacques Mahillon

Microbiological Research, 2024, 283, 127697
DOI: 10.1016/j.micres.2024.127697

Introduction of the AAL-Toxin Polyketide Synthase Gene ALT1 into FUM1-disrupted Fusarium verticillioides Produces Metabolites with the Fumonisin Methylation Pattern

Yaoyao Li, Yuemao Shen, Xiangcheng Zhu and Liangcheng Du

J. Nat. Prod., 2009, 72, 1328
DOI: 10.1021/np900193j

Classification, Prediction, and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains

Yanran Li 然李嫣, Wei Xu 伟徐 and Yi Tang 奕唐

Journal of Biological Chemistry, 2010, 285, 22764
DOI: 10.1074/jbc.M110.128504

Robust Profiling of Cytochrome P450s (P450ome) in Notable Aspergillus spp.

Wadzani Palnam Dauda, Peter Abraham, Elkanah Glen, Charles Oluwaseun Adetunji, Shakira Ghazanfar, Shafaqat Ali, Majid Al-Zahrani, Mawuli Kwamla Azameti, Sheik Emmanuel Laykay Alao, Afiniki Bawa Zarafi, Maryam Peter Abraham and Hannatu Musa

Life, 2022, 12, 451
DOI: 10.3390/life12030451

Periconones B–E, new meroterpenoids from endophytic fungus Periconia sp.

Ji-Mei Liu, De-Wu Zhang, Min Zhang, Ri-Dao Chen, Zheng Yan, Jian-Yuan Zhao, Jin-Lian Zhao, Nan Wang and Jun-Gui Dai

Chinese Chemical Letters, 2017, 28, 248
DOI: 10.1016/j.cclet.2016.07.031

Peniphenone and Penilactone Formation in Penicillium crustosum via 1,4-Michael Additions of ortho-Quinone Methide from Hydroxyclavatol to γ-Butyrolactones from Crustosic Acid

Jie Fan, Ge Liao, Florian Kindinger, Lena Ludwig-Radtke, Wen-Bing Yin and Shu-Ming Li

J. Am. Chem. Soc., 2019, 141, 4225
DOI: 10.1021/jacs.9b00110

Concise Biosynthesis of Phenylfuropyridones in Fungi

Zhuan Zhang, Tianzhang Qiao, Kenji Watanabe and Yi Tang

Angew Chem Int Ed, 2020, 59, 19889
DOI: 10.1002/anie.202008321

Regio‐ and Stereoselective Oxidative Phenol Coupling in Aspergillus niger

Christian Gil Girol, Katja M. Fisch, Thorsten Heinekamp, Stefan Günther, Wolfgang Hüttel, Jörn Piel, Axel A. Brakhage and Michael Müller

Angew Chem Int Ed, 2012, 51, 9788
DOI: 10.1002/anie.201203603

Polyketides, Toxins and Pigments in Penicillium marneffei

Emily Tam, Chi-Ching Tsang, Susanna Lau and Patrick Woo

Toxins, 2015, 7, 4421
DOI: 10.3390/toxins7114421

Applications of microbial co‐cultures in polyketides production

X. Xu, R. Qu, W. Wu, C. Jiang, D. Shao and J. Shi

J Appl Microbiol, 2021, 130, 1023
DOI: 10.1111/jam.14845

Design of Fungal Co-Cultivation Based on Comparative Metabolomics and Bioactivity for Discovery of Marine Fungal Agrochemicals

Ernest Oppong-Danquah, Paulina Budnicka, Martina Blümel and Deniz Tasdemir

Marine Drugs, 2020, 18, 73
DOI: 10.3390/md18020073

Peering into the Black Box of Fungal Polyketide Biosynthesis

Kira J. Weissman

ChemBioChem, 2010, 11, 485
DOI: 10.1002/cbic.201000023

Draft Genome Sequence of the Lichen-Forming Fungus Ramalina intermedia Strain YAF0013

Yi Wang, Xiaolong Yuan, Li Chen, Xinyu Wang and Changtian Li

Genome Announc, 2018, 6
DOI: 10.1128/genomeA.00478-18

Physically Discrete β-Lactamase-Type Thioesterase Catalyzes Product Release in Atrochrysone Synthesis by Iterative Type I Polyketide Synthase

Takayoshi Awakawa, Kosuke Yokota, Nobutaka Funa, Fuminao Doi, Naoki Mori, Hidenori Watanabe and Sueharu Horinouchi

Chemistry & Biology, 2009, 16, 613
DOI: 10.1016/j.chembiol.2009.04.004

Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain

Leibniz Hang, Man‐Cheng Tang, Colin J. B. Harvey, Claire G. Page, Jian Li, Yiu‐Sun Hung, Nicholas Liu, Maureen E. Hillenmeyer and Yi Tang

Angewandte Chemie, 2017, 129, 9684
DOI: 10.1002/ange.201705237

In silicoprediction and characterisation of secondary metabolite clusters in the plant pathogenic fungusVerticillium dahliae

Xiaoqian Shi-Kunne, Roger de Pedro Jové, Jasper R L Depotter, Malaika K Ebert, Michael F Seidl and Bart P H J Thomma

FEMS Microbiology Letters, 2019, 366
DOI: 10.1093/femsle/fnz081

A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

Kangjian Qiao, Hui Zhou, Wei Xu, Wenjun Zhang, Neil Garg and Yi Tang

Org. Lett., 2011, 13, 1758
DOI: 10.1021/ol200288w

Opportunities for enzyme catalysis in natural product chemistry

Steffen Friedrich and Frank Hahn

Tetrahedron, 2015, 71, 1473
DOI: 10.1016/j.tet.2014.12.026

Structure, Absolute Configuration, and Conformational Study of 12-Membered Macrolides from the Fungus Dendrodochium sp. Associated with the Sea Cucumber Holothuria nobilis Selenka

Peng Sun, Dong-Xiao Xu, Attila Mándi, Tibor Kurtán, Tie-Jun Li, Barbara Schulz and Wen Zhang

J. Org. Chem., 2013, 78, 7030
DOI: 10.1021/jo400861j

Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase

Jaclyn M. Winter, Michio Sato, Satoru Sugimoto, Grace Chiou, Neil K. Garg, Yi Tang and Kenji Watanabe

J. Am. Chem. Soc., 2012, 134, 17900
DOI: 10.1021/ja3090498

Polyketide Synthase Gene Expression in Relation to Chloromonilicin and Melanin Production in Monilinia fructicola

Fang-Yi Yu, Chiu-Min Chiu, Yue-Zhi Lee, Shiow-Ju Lee, Chien-Ming Chou, Bang-Jau You, Dai-Keng Hsieh, Maw-Rong Lee, Miin-Huey Lee and Richard M. Bostock

Phytopathology®, 2020, 110, 1465
DOI: 10.1094/PHYTO-02-20-0059-R

Unraveling polyketide synthesis in members of the genus Aspergillus

Yi-Ming Chiang, Berl R. Oakley, Nancy P. Keller and Clay C. C. Wang

Appl Microbiol Biotechnol, 2010, 86, 1719
DOI: 10.1007/s00253-010-2525-3

Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges

Ton That Huu Dat, Georg Steinert, Nguyen Thi Kim Cuc, Pham Viet Cuong, Hauke Smidt and Detmer Sipkema

Marine Drugs, 2022, 21, 29
DOI: 10.3390/md21010029

Crystal structure of the condensation domain from lovastatin polyketide synthase

Lei Wang, Meijuan Yuan and Jianting Zheng

Synthetic and Systems Biotechnology, 2019, 4, 10
DOI: 10.1016/j.synbio.2018.11.003

Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum

Hui-Xiang Yang, Jin-Tao Ma, Juan He, Zheng-Hui Li, Rong Huang, Tao Feng and Ji-Kai Liu

ACS Omega, 2021, 6, 25089
DOI: 10.1021/acsomega.1c04418

Strobilurin biosynthesis in Basidiomycete fungi

Risa Nofiani, Kate de Mattos-Shipley, Karen E. Lebe, Li-Chen Han, Zafar Iqbal, Andrew M. Bailey, Christine L. Willis, Thomas J. Simpson and Russell J. Cox

Nat Commun, 2018, 9
DOI: 10.1038/s41467-018-06202-4

Selective production, relationship and controversy between Monascus pigments and citrinin

Xueling Qin, Bin Xie, Xuanli Zong, Xiang Yu and Yanli Feng

Food Bioscience, 2023, 56, 103233
DOI: 10.1016/j.fbio.2023.103233

Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus

Lin Du, Tianjiao Zhu, Hongbing Liu, Yuchun Fang, Weiming Zhu and Qianqun Gu

J. Nat. Prod., 2008, 71, 1837
DOI: 10.1021/np800303t

β‐Chain Extension: A New Mode of Carbon–Carbon Bond Formation and Chain Extension by Polyketide Synthases

Russell J. Cox

ChemBioChem, 2014, 15, 27
DOI: 10.1002/cbic.201300660

Genomic Analysis of the Xanthoria elegans and Polyketide Synthase Gene Mining Based on the Whole Genome

Xiaolong Yuan, Yunqing Li, Ting Luo, Wei Bi, Jiaojun Yu and Yi Wang

Mycobiology, 2023, 51, 36
DOI: 10.1080/12298093.2023.2175428

The Diversity of Linear Conjugated Polyenes and Colours in Nature: Raman Spectroscopy as a Diagnostic Tool

Lenize F. Maia, Vanessa E. De Oliveira, Howell G. M. Edwards and Luiz Fernando C. De Oliveira

ChemPhysChem, 2021, 22, 231
DOI: 10.1002/cphc.202000818

A Single Module Type I Polyketide Synthase Directs de Novo Macrolactone Biogenesis during Galbonolide Biosynthesis in Streptomyces galbus

Hyun-Ju Kim, Suman Karki, So-Yeon Kwon, Si-Hyung Park, Baek-Hie Nahm, Yeon-Ki Kim and Hyung-Jin Kwon

Journal of Biological Chemistry, 2014, 289, 34557
DOI: 10.1074/jbc.M114.602334

Insights into Multienzyme Docking in Hybrid PKS–NRPS Megasynthetases Revealed by Heterologous Expression and Genetic Engineering

Yanyan Li , Kira J. Weissman and Rolf Müller

ChemBioChem, 2010, 11, 1069
DOI: 10.1002/cbic.201000103

Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products

Ling Liu, Man-Cheng Tang and Yi Tang

J. Am. Chem. Soc., 2019, 141, 19538
DOI: 10.1021/jacs.9b09669

Protein engineering towards natural product synthesis and diversification

Angelica O Zabala, Ralph A Cacho and Yi Tang

Journal of Industrial Microbiology and Biotechnology, 2012, 39, 227
DOI: 10.1007/s10295-011-1044-2

Secondary metabolite biosynthetic diversity in the fungal family Hypoxylaceae and Xylaria hypoxylon

E. Kuhnert, J.C. Navarro-Muñoz, K. Becker, M. Stadler, J. Collemare and R.J. Cox

Studies in Mycology, 2021, 99, 100118
DOI: 10.1016/j.simyco.2021.100118

Genetic Manipulation of the Fusarium fujikuroi Fusarin Gene Cluster Yields Insight into the Complex Regulation and Fusarin Biosynthetic Pathway

Eva-Maria Niehaus, Karin Kleigrewe, Philipp Wiemann, Lena Studt, Christian M.K. Sieber, Lanelle R. Connolly, Michael Freitag, Ulrich Güldener, Bettina Tudzynski and Hans-Ulrich Humpf

Chemistry & Biology, 2013, 20, 1055
DOI: 10.1016/j.chembiol.2013.07.004

Fungi as chemical industries and genetic engineering for the production of biologically active secondary metabolites

Abid Ali Khan, Nafees Bacha, Bashir Ahmad, Ghosia Lutfullah, Umar Farooq and Russell John Cox

Asian Pacific Journal of Tropical Biomedicine, 2014, 4, 859
DOI: 10.12980/APJTB.4.2014APJTB-2014-0230

Starter unit specificity directs genome mining of polyketide synthase pathways in fungi

Jason M. Crawford, Anna L. Vagstad, Kenneth C. Ehrlich and Craig A. Townsend

Bioorganic Chemistry, 2008, 36, 16
DOI: 10.1016/j.bioorg.2007.11.002

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

Wenjun Zhang, Yanran Li and Yi Tang

Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 20683
DOI: 10.1073/pnas.0809084105

Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362

Huawei Lv, Haibo Su, Yaxin Xue, Jia Jia, Hongkai Bi, Shoubao Wang, Jinkun Zhang, Mengdi Zhu, Mahmoud Emam, Hong Wang, Kui Hong and Xing-Nuo Li

Mar Life Sci Technol, 2023, 5, 232
DOI: 10.1007/s42995-023-00170-5

Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways

Heather L Condurso and Steven D Bruner

Current Opinion in Chemical Biology, 2012, 16, 162
DOI: 10.1016/j.cbpa.2012.02.002

Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes

Chantel D. Campbell and John C. Vederas

Biopolymers, 2010, 93, 755
DOI: 10.1002/bip.21428

Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale

Hai-Yan Cao, Cheng Yi, Sen-Feng Sun, Yong Li and Yun-Bao Liu

J. Nat. Prod., 2022, 85, 148
DOI: 10.1021/acs.jnatprod.1c00878

Lichen Biosynthetic Gene Clusters. Part I. Genome Sequencing Reveals a Rich Biosynthetic Potential

Robert L. Bertrand, Mona Abdel-Hameed and John L. Sorensen

J. Nat. Prod., 2018, 81, 723
DOI: 10.1021/acs.jnatprod.7b00769

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and in Saccharomyces cerevisiae

Wei Xu, Xiaolu Cai, Michael E. Jung and Yi Tang

J. Am. Chem. Soc., 2010, 132, 13604
DOI: 10.1021/ja107084d

FT-ICR-MS Characterization of Intermediates in the Biosynthesis of the α-Methylbutyrate Side Chain of Lovastatin by the 277 kDa Polyketide Synthase LovF

Michael J. Meehan, Xinkai Xie, Xiling Zhao, Wei Xu, Yi Tang and Pieter C. Dorrestein

Biochemistry, 2011, 50, 287
DOI: 10.1021/bi1014776

One Metabolite, Two Pathways: Convergence of Polypropionate Biosynthesis in Fungi and Marine Molluscs

Adele Cutignano, Guido Villani and Angelo Fontana

Org. Lett., 2012, 14, 992
DOI: 10.1021/ol2032653

Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone

Yi-Ming Chiang, Kristen M. Meyer, Michael Praseuth, Scott E. Baker, Kenneth S. Bruno and Clay C.C. Wang

Fungal Genetics and Biology, 2011, 48, 430
DOI: 10.1016/j.fgb.2010.12.001

Active Site Comparisons and Catalytic Mechanisms of the Hot Dog Superfamily

Jason W. Labonte and Craig A. Townsend

Chem. Rev., 2013, 113, 2182
DOI: 10.1021/cr300169a

Isolation and characterization of a non-reducing polyketide synthase gene from the lichen-forming fungus Usnea longissima

Yi Wang, Jung A Kim, Yong Hwa Cheong, Young Jin Koh and Jae-Seoun Hur

Mycol Progress, 2012, 11, 75
DOI: 10.1007/s11557-010-0730-1

Recent advancements in the biosynthetic mechanisms for polyketide‐derived mycotoxins

Justin Huffman, Ryan Gerber and Liangcheng Du

Biopolymers, 2010, 93, 764
DOI: 10.1002/bip.21483

Morphological and Molecular Characterization of Some Alternaria Species Isolated from Tomato Fruits Concerning Mycotoxin Production and Polyketide Synthase Genes

Abdelrahman Saleem and Amany A. El-Shahir

Plants, 2022, 11, 1168
DOI: 10.3390/plants11091168

Microbial Communities of Cladonia Lichens and Their Biosynthetic Gene Clusters Potentially Encoding Natural Products

Tânia Keiko Shishido, Matti Wahlsten, Pia Laine, Jouko Rikkinen, Taina Lundell and Petri Auvinen

Microorganisms, 2021, 9, 1347
DOI: 10.3390/microorganisms9071347

Phylogeny of type I polyketide synthases (PKSs) in fungal entomopathogens and expression analysis of PKS genes in Beauveria bassiana BCC 2660

Juntira Punya, Pratchya Swangmaneecharern, Suparat Pinsupa, Pornpen Nitistaporn, Suranat Phonghanpot, Viyada Kunathigan, Supapon Cheevadhanarak, Morakot Tanticharoen and Alongkorn Amnuaykanjanasin

Fungal Biology, 2015, 119, 538
DOI: 10.1016/j.funbio.2015.02.005

A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates

Samantha L. Kilgour, Robert Jenkins and Manuela Tosin

Chemistry A European J, 2019, 25, 16511
DOI: 10.1002/chem.201903661

The nonribosomal peptide and polyketide synthetic gene clusters in two strains of entomopathogenic fungi inCordyceps

Wen-Jing Wang, Heiko Vogel, Yi-Jian Yao and Liyan Ping

FEMS Microbiol Lett, 2012, 336, 89
DOI: 10.1111/j.1574-6968.2012.02658.x

A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa

Minou Nowrousian

Curr Genet, 2009, 55, 185
DOI: 10.1007/s00294-009-0236-z

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

Jaclyn M. Winter, Duilio Cascio, David Dietrich, Michio Sato, Kenji Watanabe, Michael R. Sawaya, John C. Vederas and Yi Tang

J. Am. Chem. Soc., 2015, 137, 9885
DOI: 10.1021/jacs.5b04520

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

Hedda Schrey, Christopher Lambert and Marc Stadler

imafungus, 2025, 16
DOI: 10.3897/imafungus.16.142462

Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis inM. furfurby cDNA subtraction technology

W. Hort, S. Lang, S. Brunke, P. Mayser and B. Hube

Med Mycol, 2009, 47, 248
DOI: 10.1080/13693780802238842

Genetic localization of epicoccamide biosynthetic gene cluster in Epicoccum nigrum KACC 40642

Eun Ha Choi, Si-Hyung Park and Hyung-Jin Kwon

JABC, 2022, 65, 159
DOI: 10.3839/jabc.2022.021

Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

Yi Zou, Wei Xu, Yuta Tsunematsu, Mancheng Tang, Kenji Watanabe and Yi Tang

Org. Lett., 2014, 16, 6390
DOI: 10.1021/ol503179v

Characterization of two cytochrome P450 monooxygenase genes of the pyripyropene biosynthetic gene cluster from Penicillium coprobium

Jie Hu, Hiroto Okawa, Kentaro Yamamoto, Kazuhiko Oyama, Masaaki Mitomi and Hiroyuki Anzai

J Antibiot, 2011, 64, 221
DOI: 10.1038/ja.2010.162

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans

Yi-Ming Chiang, Edyta Szewczyk, Ashley D. Davidson, Nancy Keller, Berl R. Oakley and Clay C. C. Wang

J. Am. Chem. Soc., 2009, 131, 2965
DOI: 10.1021/ja8088185

Investigation of Fungal Iterative Polyketide Synthase Functions Using Partially Assembled Intermediates

Zhizeng Gao, Jingjing Wang, Amy K. Norquay, Kangjian Qiao, Yi Tang and John C. Vederas

J. Am. Chem. Soc., 2013, 135, 1735
DOI: 10.1021/ja4001823

Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

Shuhao Wang, Yuquan Xu, Erin A. Maine, E.M. Kithsiri Wijeratne, Patricia Espinosa-Artiles, A.A. Leslie Gunatilaka and István Molnár

Chemistry & Biology, 2008, 15, 1328
DOI: 10.1016/j.chembiol.2008.10.006

Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme

Lukas Kahlert, Miranda Villanueva, Russell J. Cox and Elizabeth J. Skellam

Angewandte Chemie, 2021, 133, 11524
DOI: 10.1002/ange.202100969

Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota

Daniel P. Lawrence, Scott Kroken, Barry M. Pryor, A. Elizabeth Arnold and Geraldine Butler

PLoS ONE, 2011, 6, e28231
DOI: 10.1371/journal.pone.0028231

Current Insight into Traditional and Modern Methods in Fungal Diversity Estimates

Ajay Kumar Gautam, Rajnish Kumar Verma, Shubhi Avasthi, Sushma, Yogita Bohra, Bandarupalli Devadatha, Mekala Niranjan and Nakarin Suwannarach

JoF, 2022, 8, 226
DOI: 10.3390/jof8030226

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

Katja M. Fisch, Walid Bakeer, Ahmed A. Yakasai, Zhongshu Song, Jennifer Pedrick, Zahida Wasil, Andrew M. Bailey, Colin M. Lazarus, Thomas J. Simpson and Russell J. Cox

J. Am. Chem. Soc., 2011, 133, 16635
DOI: 10.1021/ja206914q

Biochemistry‐Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides

Junya Takino, Akari Kotani, Taro Ozaki, Wenquan Peng, Jie Yu, Yian Guo, Susumu Mochizuki, Kazuya Akimitsu, Masaru Hashimoto, Tao Ye, Atsushi Minami and Hideaki Oikawa

Angew Chem Int Ed, 2021, 60, 23403
DOI: 10.1002/anie.202110658

Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway

Nicholas Liu, Yiu-Sun Hung, Shu-Shan Gao, Leibniz Hang, Yi Zou, Yit-Heng Chooi and Yi Tang

Org. Lett., 2017, 19, 3560
DOI: 10.1021/acs.orglett.7b01534

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger

K. M. Fisch, A. F. Gillaspy, M. Gipson, J. C. Henrikson, A. R. Hoover, L. Jackson, F. Z. Najar, H. Wägele and R. H. Cichewicz

J Ind Microbiol Biotechnol, 2009, 36, 1199
DOI: 10.1007/s10295-009-0601-4

Thioesterase Domains of Fungal Nonreducing Polyketide Synthases Act as Decision Gates during Combinatorial Biosynthesis

Yuquan Xu, Tong Zhou, Shuwei Zhang, Li-Jiang Xuan, Jixun Zhan and István Molnár

J. Am. Chem. Soc., 2013, 135, 10783
DOI: 10.1021/ja4041362

Assembly of Melleolide Antibiotics Involves a Polyketide Synthase with Cross-Coupling Activity

Gerald Lackner, Markus Bohnert, Jonas Wick and Dirk Hoffmeister

Chemistry & Biology, 2013, 20, 1101
DOI: 10.1016/j.chembiol.2013.07.009

Does the Future of Antibiotics Lie in Secondary Metabolites Produced by Xenorhabdus spp.? A Review

E. Booysen and L. M. T. Dicks

Probiotics & Antimicro. Prot., 2020, 12, 1310
DOI: 10.1007/s12602-020-09688-x

Genetic localization of the orevactaene/epipyrone biosynthetic gene cluster in Epicoccum nigrum

Yoon Ji Lim, Eunha Choi, Si-Hyung Park and Hyung-Jin Kwon

Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127242
DOI: 10.1016/j.bmcl.2020.127242

Unlocking Fungal Cryptic Natural Products

Yi-Ming Chiang, Kuan-Han Lee, James F. Sanchez, Nancy P. Keller and Clay C. C. Wang

Natural Product Communications, 2009, 4
DOI: 10.1177/1934578X0900401113

Cloning and Functional Characterization of the Polyketide Synthases Based on Genome Mining of Preussia isomera XL-1326

Qingpei Liu, Dan Zhang, Yao Xu, Shuaibiao Gao, Yifu Gong, Xianhua Cai, Ming Yao and Xiaolong Yang

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.819086

Identification of a Polyketide Synthase Required for Alternariol (AOH) and Alternariol-9-Methyl Ether (AME) Formation in Alternaria alternata

Debjani Saha, Ramona Fetzner, Britta Burkhardt, Joachim Podlech, Manfred Metzler, Ha Dang, Christopher Lawrence, Reinhard Fischer and Jae-Hyuk Yu

PLoS ONE, 2012, 7, e40564
DOI: 10.1371/journal.pone.0040564

Formation of 3-Orsellinoxypropanoic Acid in Penicillum crustosum is Catalyzed by a Bifunctional Nonreducing Polyketide Synthase

Pan Xiang and Shu-Ming Li

Org. Lett., 2022, 24, 462
DOI: 10.1021/acs.orglett.1c04189

Linking a polyketide synthase gene cluster to 6-pentyl-alpha-pyrone, a Trichoderma metabolite with diverse bioactivities

Daniel Flatschacher, Alexander Eschlböck, Siebe Pierson, Ulrike Schreiner, Valentina Stock, Arne Schiller, David Ruso, Maria Doppler, Veronika Ruzsanyi, Mario Gründlinger, Christoph Büschl, Rainer Schuhmacher and Susanne Zeilinger

Microb Cell Fact, 2025, 24
DOI: 10.1186/s12934-025-02718-9

pks63787, a Polyketide Synthase Gene Responsible for the Biosynthesis of Benzenoids in the Medicinal Mushroom Antrodia cinnamomea

Po-Wei Yu, Ya-Chih Chang, Ruey-Fen Liou, Tzong-Huei Lee and Shean-Shong Tzean

J. Nat. Prod., 2016, 79, 1485
DOI: 10.1021/acs.jnatprod.5b00798

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

Laura M. Halo, James W. Marshall, Ahmed A. Yakasai, Zhongshu Song, Craig P. Butts, Matthew P. Crump, Mary Heneghan, Andrew M. Bailey, Thomas J. Simpson, Colin. M. Lazarus and Russell J. Cox

ChemBioChem, 2008, 9, 585
DOI: 10.1002/cbic.200700390

Insights into 6‐Methylsalicylic Acid Bio‐assembly by Using Chemical Probes

James S. Parascandolo, Judith Havemann, Helen K. Potter, Fanglu Huang, Elena Riva, Jack Connolly, Ina Wilkening, Lijiang Song, Peter F. Leadlay and Manuela Tosin

Angew Chem Int Ed, 2016, 55, 3463
DOI: 10.1002/anie.201509038

Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research

Fabrizio Alberti, Saraa Kaleem and Jack A. Weaver

Biology Open, 2020, 9
DOI: 10.1242/bio.056010

Heterologe Produktion pilzlicher Maleidride enthüllt die kryptische Cyclisierung in ihrer Biosynthese

Katherine Williams, Agnieszka J. Szwalbe, Nicholas P. Mulholland, Jason L. Vincent, Andrew M. Bailey, Christine L. Willis, Thomas J. Simpson and Russell J. Cox

Angewandte Chemie, 2016, 128, 6896
DOI: 10.1002/ange.201511882

Precursor Supply Increases the Accumulation of 4-Hydroxy-6-(4-hydroxyphenyl)-α-pyrone after NRPS–PKS Gene Expression

Wen Li, Jie Fan, Ge Liao, Wen-Bing Yin and Shu-Ming Li

J. Nat. Prod., 2021, 84, 2380
DOI: 10.1021/acs.jnatprod.1c00120

Engineering Fungal Nonreducing Polyketide Synthase by Heterologous Expression and Domain Swapping

Hsu-Hua Yeh, Shu-Lin Chang, Yi-Ming Chiang, Kenneth S. Bruno, Berl R. Oakley, Tung-Kung Wu and Clay C. C. Wang

Org. Lett., 2013, 15, 756
DOI: 10.1021/ol303328t

Biosynthesis of Annullatin D in Penicillium roqueforti Implies Oxidative Lactonization between Two Hydroxyl Groups Catalyzed by a BBE-like Enzyme

Pan Xiang, Bastian Kemmerich, Li Yang and Shu-Ming Li

Org. Lett., 2022, 24, 6072
DOI: 10.1021/acs.orglett.2c02438

Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products

Fernando Guzmán-Chávez, Reto D. Zwahlen, Roel A. L. Bovenberg and Arnold J. M. Driessen

Front. Microbiol., 2018, 9
DOI: 10.3389/fmicb.2018.02768

Probing Interactions in Fungal PKS

Kira J. Weissman

Chemistry & Biology, 2013, 20, 1089
DOI: 10.1016/j.chembiol.2013.09.001

Genomic Features of Taiwanofungus gaoligongensis and the Transcriptional Regulation of Secondary Metabolite Biosynthesis

Yadong Zhang, Yi Wang, Xiaolong Yuan, Hongling Zhang and Yuan Zheng

JoF, 2024, 10, 826
DOI: 10.3390/jof10120826

Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway

Danielle A. Yee, Thomas B. Kakule, Wei Cheng, Mengbin Chen, Christine T. Y. Chong, Yang Hai, Leibniz F. Hang, Yiu-Sun Hung, Nicholas Liu, Masao Ohashi, Ikechukwu C. Okorafor, Yongxiang Song, Mancheng Tang, Zhuan Zhang and Yi Tang

J. Am. Chem. Soc., 2020, 142, 710
DOI: 10.1021/jacs.9b13046

Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvum

Jérôme Collemare, Scott Griffiths, Yuichiro Iida, Mansoor Karimi Jashni, Evy Battaglia, Russell J. Cox, Pierre J. G. M. de Wit and Olivier Lespinet

PLoS ONE, 2014, 9, e85877
DOI: 10.1371/journal.pone.0085877

Benzoyl ester formation in Aspergillus ustus by hijacking the polyketide acyl intermediates with alcohols

Liujuan Zheng and Shu-Ming Li

Arch Microbiol, 2021, 203, 1795
DOI: 10.1007/s00203-021-02182-0

Structural analysis of protein–protein interactions in type I polyketide synthases

Wei Xu, Kangjian Qiao and Yi Tang

Critical Reviews in Biochemistry and Molecular Biology, 2013, 48, 98
DOI: 10.3109/10409238.2012.745476

Cooperation between a Coenzyme A-Independent Stand-Alone Initiation Module and an Iterative Type I Polyketide Synthase during Synthesis of Mycobacterial Phenolic Glycolipids

Weiguo He, Clifford E. Soll, Sivagami Sundaram Chavadi, Guangtao Zhang, J. David Warren and Luis E. N. Quadri

J. Am. Chem. Soc., 2009, 131, 16744
DOI: 10.1021/ja904792q

Discovery of New Natural Products by Intact‐Cell Mass Spectrometry and LC‐SPE‐NMR: Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea

Yu‐Liang Yang, Wen‐Ying Liao, Wan‐Yun Liu, Chih‐Chuang Liaw, Chia‐Ning Shen, Zih‐You Huang and Shih‐Hsiung Wu

Chemistry A European J, 2009, 15, 11573
DOI: 10.1002/chem.200901556

Investigation of Citrinin and Pigment Biosynthesis Mechanisms in Monascus purpureus by Transcriptomic Analysis

Bin Liang, Xin-Jun Du, Ping Li, Chan-Chan Sun and Shuo Wang

Front. Microbiol., 2018, 9
DOI: 10.3389/fmicb.2018.01374

Magnaporthe griseaavirulence geneACE1belongs to an infection‐specific gene cluster involved in secondary metabolism

Jérôme Collemare, Mikaël Pianfetti, Anne‐Elodie Houlle, Damien Morin, Laurent Camborde, Marie‐Josèphe Gagey, Crystel Barbisan, Isabelle Fudal, Marc‐Henri Lebrun and Heidi U. Böhnert

New Phytologist, 2008, 179, 196
DOI: 10.1111/j.1469-8137.2008.02459.x

Biosynthetic Origins of the Epoxyquinone Skeleton in Epoxyquinols A and B

Katsuki Fujita, Fumihiro Ishikawa and Hideaki Kakeya

J. Nat. Prod., 2014, 77, 2707
DOI: 10.1021/np5004615

Biosynthesis of sphinganine-analog mycotoxins

L. Du, X. Zhu, R. Gerber, J. Huffman, L. Lou, J. Jorgenson, F. Yu, K. Zaleta-Rivera and Q. Wang

J Ind Microbiol Biotechnol, 2008, 35, 455
DOI: 10.1007/s10295-008-0316-y

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

Yi He, Bin Wang, Wanping Chen, Russell J. Cox, Jingren He and Fusheng Chen

Biotechnology Advances, 2018, 36, 739
DOI: 10.1016/j.biotechadv.2018.02.001

Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies

Cancan Wang, Chenjie Wang, Yanjun Liu, Yujie Yue, Xingyue Lu, Hong Wang, Youmin Ying, Jianwei Chen and John R. Spear

Appl Environ Microbiol, 2024, 90
DOI: 10.1128/aem.01603-24

Dereplication-guided isolation of depsides thielavins S–T and lecanorins D–F from the endophytic fungus Setophoma sp.

Lívia S. de Medeiros, Lucas M. Abreu, Anita Nielsen, Hanne Ingmer, Thomas O. Larsen, Kristian F. Nielsen and Edson Rodrigues-Filho

Phytochemistry, 2015, 111, 154
DOI: 10.1016/j.phytochem.2014.12.020

Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

Ralph A. Cacho, Justin Thuss, Wei Xu, Randy Sanichar, Zhizeng Gao, Allison Nguyen, John C. Vederas and Yi Tang

J. Am. Chem. Soc., 2015, 137, 15688
DOI: 10.1021/jacs.5b11814

Time-resolved decoding of metabolic signatures of in vitro growth of the hemibiotrophic pathogen Colletotrichum sublineolum

Fidele Tugizimana, Arnaud T. Djami-Tchatchou, Johannes F. Fahrmann, Paul A. Steenkamp, Lizelle A. Piater and Ian A. Dubery

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-38692-7

Dissecting the Functional Role of Polyketide Synthases in Dictyostelium discoideum

Ratna Ghosh, Arush Chhabra, Pallavi A. Phatale, Subodh K. Samrat, Jyoti Sharma, Anuradha Gosain, Debasisa Mohanty, Shweta Saran and Rajesh S. Gokhale

Journal of Biological Chemistry, 2008, 283, 11348
DOI: 10.1074/jbc.M709588200

Production of Monacolin K in Monascus pilosus: Comparison between Industrial Strains and Analysis of Its Gene Clusters

Weihua Dai, Yanchun Shao and Fusheng Chen

Microorganisms, 2021, 9, 747
DOI: 10.3390/microorganisms9040747

Unveiling the potential of Daldinia eschscholtzii MFLUCC 19-0629 through bioactivity and bioinformatics studies for enhanced sustainable agriculture production

Siraprapa Brooks, Jack A. Weaver, Anthikan Klomchit, Shumukh A. Alharthi, Thanyarat Onlamun, Rithika Nurani, Thienthu Khanh Vong, Fabrizio Alberti and Claudio Greco

Front. Chem. Biol., 2024, 3
DOI: 10.3389/fchbi.2024.1362147

Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis

Hui Zhou, Kangjian Qiao, Zhizeng Gao, Michael J. Meehan, Jesse W.-H. Li, Xiling Zhao, Pieter C. Dorrestein, John C. Vederas and Yi Tang

J. Am. Chem. Soc., 2010, 132, 4530
DOI: 10.1021/ja100060k

A Polyketide Cyclase That Forms Medium-Ring Lactones

De-Wei Gao, Cooper S. Jamieson, Gaoqian Wang, Yan Yan, Jiahai Zhou, K. N. Houk and Yi Tang

J. Am. Chem. Soc., 2021, 143, 80
DOI: 10.1021/jacs.0c11226

Genome-Based Analysis of Verticillium Polyketide Synthase Gene Clusters

Mohammad Sayari, Aria Dolatabadian, Mohamed El-Shetehy, Pawanpuneet Kaur Rehal and Fouad Daayf

Biology, 2022, 11, 1252
DOI: 10.3390/biology11091252

Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Lukas Kahlert, Carsten Schotte and Russell J. Cox

Synthesis, 2021, 53, 2381
DOI: 10.1055/a-1401-2716

Diversity and evolution of polyketide biosynthesis gene clusters in the Ceratocystidaceae

Mohammad Sayari, Emma T. Steenkamp, Magriet A. van der Nest and Brenda D. Wingfield

Fungal Biology, 2018, 122, 856
DOI: 10.1016/j.funbio.2018.04.011

Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis

Katherine Williams, Agnieszka J. Szwalbe, Nicholas P. Mulholland, Jason L. Vincent, Andrew M. Bailey, Christine L. Willis, Thomas J. Simpson and Russell J. Cox

Angew Chem Int Ed, 2016, 55, 6784
DOI: 10.1002/anie.201511882

Status of macrofungal diversity in the wet evergreen forests of Agasthyamala Biosphere Reserve, Western Ghats, India

Kurunnan Kandy Akshaya, Arumugam Karthikeyan and Cheravengat Kunhikannan

J. Threat. Taxa, 2023, 15, 23575
DOI: 10.11609/jott.8469.15.7.23575-23586

Molecular Diversity Sculpted by Fungal PKS–NRPS Hybrids

Daniela Boettger and Christian Hertweck

ChemBioChem, 2013, 14, 28
DOI: 10.1002/cbic.201200624

Evolution and Diversity of Assembly-Line Polyketide Synthases

Aleksandra Nivina, Kai P. Yuet, Jake Hsu and Chaitan Khosla

Chem. Rev., 2019, 119, 12524
DOI: 10.1021/acs.chemrev.9b00525

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

Hui Zhou 周卉, Kangjian Qiao 乔康健, Zhizeng Gao 高志增, John C. Vederas and Yi Tang 唐奕

Journal of Biological Chemistry, 2010, 285, 41412
DOI: 10.1074/jbc.M110.183574

Probing the Selectivity and Protein⋅Protein Interactions of a Nonreducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Joel Bruegger, Bob Haushalter, Anna Vagstad, Gaurav Shakya, Nathan Mih, Craig A. Townsend, Michael D. Burkart and Shiou-Chuan Tsai

Chemistry & Biology, 2013, 20, 1135
DOI: 10.1016/j.chembiol.2013.07.012

Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases

Carly Bond, Yi Tang and Li Li

Fungal Genetics and Biology, 2016, 89, 52
DOI: 10.1016/j.fgb.2016.01.005

Genome-Based Deletion Analysis Reveals the Prenyl Xanthone Biosynthesis Pathway in Aspergillus nidulans

James F. Sanchez, Ruth Entwistle, Jui-Hsiang Hung, Junko Yaegashi, Sofina Jain, Yi-Ming Chiang, Clay C. C. Wang and Berl R. Oakley

J. Am. Chem. Soc., 2011, 133, 4010
DOI: 10.1021/ja1096682

Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme

Lukas Kahlert, Miranda Villanueva, Russell J. Cox and Elizabeth J. Skellam

Angew Chem Int Ed, 2021, 60, 11423
DOI: 10.1002/anie.202100969

Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone–Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii

Lin Chen, Shu-Bin Niu, Li Li, Gang Ding, Meng Yu, Gui-shan Zhang, Meng-hua Wang, Lu-ying Li, Tao Zhang, Hong-Mei Jia, Hong-wu Zhang, Hai Shang, Xing-zhong Liu and Zhong-mei Zou

J. Nat. Prod., 2017, 80, 1944
DOI: 10.1021/acs.jnatprod.7b00190

Synthetic biological approaches to natural product biosynthesis

Jaclyn M Winter and Yi Tang

Current Opinion in Biotechnology, 2012, 23, 736
DOI: 10.1016/j.copbio.2011.12.016

Total Synthesis and Stereochemical Assignment of Alternapyrone

Hui Zhang, Jiaxuan Feng, Di Wang, Bencan Tang, Chao Xu and Tao Ye

Molecules, 2025, 30, 1597
DOI: 10.3390/molecules30071597

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from Hypomyces subiculosus and Radicicol from Pochonia chlamydosporia

Christopher D. Reeves, Zhihao Hu, Ralph Reid and James T. Kealey

Appl Environ Microbiol, 2008, 74, 5121
DOI: 10.1128/AEM.00478-08

Phytotoxic Metabolites Produced by Fungi Involved in Grapevine Trunk Diseases: Progress, Challenges, and Opportunities

Pierluigi Reveglia, Regina Billones-Baaijens and Sandra Savocchia

Plants, 2022, 11, 3382
DOI: 10.3390/plants11233382

Structural and Biochemical Analysis of Protein–Protein Interactions Between the Acyl‐Carrier Protein and Product Template Domain

Jesus F. Barajas, Kara Finzel, Timothy R. Valentic, Gaurav Shakya, Nathan Gamarra, Delsy Martinez, Jordan L. Meier, Anna L. Vagstad, Adam G. Newman, Craig A. Townsend, Michael D. Burkart and Shiou‐Chuan Tsai

Angew Chem Int Ed, 2016, 55, 13005
DOI: 10.1002/anie.201605401

Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum

Carlos García-Estrada, Ricardo V. Ullán, Tania Velasco-Conde, Ramiro P. Godio, Fernando Teijeira, Inmaculada Vaca, Raúl Feltrer, Katarina Kosalková, Elba Mauriz and Juan F. Martín

Biochemical Journal, 2008, 415, 317
DOI: 10.1042/BJ20080369

Biosynthesis of Amino Acid Derived α-Pyrones by an NRPS–NRPKS Hybrid Megasynthetase in Fungi

Yang Hai, Arthur Huang and Yi Tang

J. Nat. Prod., 2020, 83, 593
DOI: 10.1021/acs.jnatprod.9b00989

Phaeosphspirone (1/1′), a pair of unique polyketide enantiomers with an unusual 6/5/5/6 tetracyclic ring from the desert plant endophytic fungus Phaeosphaeriaceae sp.

Zhen-Lu Xu, Dao-Jiang Yan, Xiang-Mei Tan, Shu-Bin Niu, Meng Yu, Bing-Da Sun, Cai-Feng Ding, Yong-Gang Zhang and Gang Ding

Phytochemistry, 2022, 194, 112969
DOI: 10.1016/j.phytochem.2021.112969

Comparative Genomics Analysis Provides New Strategies for Bacteriostatic Ability of Bacillus velezensis HAB-2

Peidong Xu, Shangqian Xie, Wenbo Liu, Pengfei Jin, Dandan Wei, Dahar Ghulam Yaseen, Yu Wang and Weiguo Miao

Front. Microbiol., 2020, 11
DOI: 10.3389/fmicb.2020.594079

The Mosaic Architecture of NRPS-PKS in the Arbuscular Mycorrhizal Fungus Gigaspora margarita Shows a Domain With Bacterial Signature

Francesco Venice, Alessandro Desirò, Gladstone Silva, Alessandra Salvioli and Paola Bonfante

Front. Microbiol., 2020, 11
DOI: 10.3389/fmicb.2020.581313

Die biosynthetische Grundlage der Polyketid‐Vielfalt

Christian Hertweck

Angewandte Chemie, 2009, 121, 4782
DOI: 10.1002/ange.200806121

The polyketide synthase gene pks4 is essential for sexual development and regulates fruiting body morphology in Sordaria macrospora

Daniel Schindler and Minou Nowrousian

Fungal Genetics and Biology, 2014, 68, 48
DOI: 10.1016/j.fgb.2014.04.008

Biosynthesis of Xylariolide D in Penicillium crustosum Implies a Chain Branching Reaction Catalyzed by a Highly Reducing Polyketide Synthase

Sina A. Stierle and Shu-Ming Li

JoF, 2022, 8, 493
DOI: 10.3390/jof8050493

Isolation and characterization of a reducing polyketide synthase gene from the lichen-forming fungus Usnea longissima

Yi Wang, Jung A. Kim, Yong Hwa Cheong, Yogesh Joshi, Young Jin Koh and Jae-Seoun Hur

J Microbiol., 2011, 49, 473
DOI: 10.1007/s12275-011-0362-4

Solanapyrone Synthase, a Possible Diels–Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani

Ken Kasahara , Takanori Miyamoto, Takashi Fujimoto, Hiroki Oguri, Tetsuo Tokiwano , Hideaki Oikawa, Yutaka Ebizuka and Isao Fujii

ChemBioChem, 2010, 11, 1245
DOI: 10.1002/cbic.201000173

Diversity of Polyketide Synthases Found in the Aspergillus and Streptomyces Genomes

James F. Sanchez, Yi-Ming Chiang and Clay C. C. Wang

Mol. Pharmaceutics, 2008, 5, 226
DOI: 10.1021/mp700139t

Assignment of a dubious gene cluster to melanin biosynthesis in the tomato fungal pathogen Cladosporium fulvum

Scott A. Griffiths, Russell J. Cox, Elysa J. R. Overdijk, Carl H. Mesarich, Benedetta Saccomanno, Colin M. Lazarus, Pierre J. G. M. de Wit, Jérôme Collemare and Richard A. Wilson

PLoS ONE, 2018, 13, e0209600
DOI: 10.1371/journal.pone.0209600

Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides

Anna Tippelt and Markus Nett

Microb Cell Fact, 2021, 20
DOI: 10.1186/s12934-021-01650-y

Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa

Sheryl B. Rubin-Pitel, Houjin Zhang, Trang Vu, Joseph S. Brunzelle, Huimin Zhao and Satish K. Nair

Chemistry & Biology, 2008, 15, 1079
DOI: 10.1016/j.chembiol.2008.08.011

Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8

Jackwee Lim, Rong Kong, Elavazhagan Murugan, Chun Loong Ho, Zhao-Xun Liang, Daiwen Yang and Maria Gasset

PLoS ONE, 2011, 6, e20549
DOI: 10.1371/journal.pone.0020549

A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogenParastagonospora nodorum

Yit-Heng Chooi, Mariano Jordi Muria-Gonzalez and Peter S. Solomon

Mycology, 2014, 5, 192
DOI: 10.1080/21501203.2014.928386

Biosynthesis of Long-Chain N-Acyl Amide by a Truncated Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Megasynthase in Fungi

Yang Hai and Yi Tang

J. Am. Chem. Soc., 2018, 140, 1271
DOI: 10.1021/jacs.7b13350

Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase

Shu-Shan Gao, Abing Duan, Wei Xu, Peiyuan Yu, Leibniz Hang, K. N. Houk and Yi Tang

J. Am. Chem. Soc., 2016, 138, 4249
DOI: 10.1021/jacs.6b01528

Genetics of Polyketide Metabolism in Aspergillus nidulans

Marie L. Klejnstrup, Rasmus J. N. Frandsen, Dorte K. Holm, Morten T. Nielsen, Uffe H. Mortensen, Thomas O. Larsen and Jakob B. Nielsen

Metabolites, 2012, 2, 100
DOI: 10.3390/metabo2010100

An HR-PKS stereo surprise

Ikuro Abe

Nat Chem Biol, 2012, 8, 322
DOI: 10.1038/nchembio.924

Psychrophilins E–H and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus Aspergillus versicolor ZLN-60

Jixing Peng, Huquan Gao, Xiaomin Zhang, Shuai Wang, Chongming Wu, Qianqun Gu, Peng Guo, Tianjiao Zhu and Dehai Li

J. Nat. Prod., 2014, 77, 2218
DOI: 10.1021/np500469b

Biomimetic Domino Knoevenagel/Cycloisomerization Strategy for the Synthesis of Citridone A and Derivatives

Aabid H. Bhat, Gastón N. Quiroga, Agustina La-Venia, Huck K. Grover and Martín J. Riveira

J. Org. Chem., 2021, 86, 12226
DOI: 10.1021/acs.joc.1c01542

Engineered fungal polyketide biosynthesis in Pichia pastoris: a potential excellent host for polyketide production

Limei Gao, Menghao Cai, Wei Shen, Siwei Xiao, Xiangshan Zhou and Yuanxing Zhang

Microb Cell Fact, 2013, 12
DOI: 10.1186/1475-2859-12-77

Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides inAspergillus nidulans

Volker Schroeckh, Kirstin Scherlach, Hans-Wilhelm Nützmann, Ekaterina Shelest, Wolfgang Schmidt-Heck, Julia Schuemann, Karin Martin, Christian Hertweck and Axel A. Brakhage

Proc. Natl. Acad. Sci. U.S.A., 2009, 106, 14558
DOI: 10.1073/pnas.0901870106

Exploiting the Biosynthetic Potential of Type III Polyketide Synthases

Yan Lim, Maybelle Go and Wen Yew

Molecules, 2016, 21, 806
DOI: 10.3390/molecules21060806

CRISPR/Cas9-assisted gene editing reveals that EgPKS, a polyketide synthase, is required for the biosynthesis of preussomerins in Edenia gomezpompae SV2

Ziqi Zhai, Mengwei Zhang, Ruya Yin, Siji Zhao, Zhen Shen, Yonglin Yang, Xuan Zhang, Jianing Wang, Yifei Qin, Dan Xu, Ligang Zhou and Daowan Lai

World J Microbiol Biotechnol, 2025, 41
DOI: 10.1007/s11274-025-04313-x

Recent advances in genome mining of secondary metabolites in Aspergillus terreus

Chun-Jun Guo and Clay C. C. Wang

Front. Microbiol., 2014, 5
DOI: 10.3389/fmicb.2014.00717

Gaining Insight Into Reactivity Differences Between Malonic Acid Half Thioesters (MAHT) and Malonic Acid Half Oxyesters (MAHO)

Sean P. Bew, G. Richard Stephenson, Jacques Rouden, Jeremy Godemert, Haseena Seylani and Luis A. Martinez‐Lozano

Chemistry A European J, 2017, 23, 4557
DOI: 10.1002/chem.201605148

Cytochrome P450 and the glycosyltransferase genes are necessary for product release from epipyrone polyketide synthase in Epicoccum nigrum

Eun Ha Choi, Si-Hyung Park and Hyung-Jin Kwon

JABC, 2021, 64, 225
DOI: 10.3839/jabc.2021.032

Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining

Takayoshi Awakawa, Xiao‐Long Yang, Toshiyuki Wakimoto and Ikuro Abe

ChemBioChem, 2013, 14, 2095
DOI: 10.1002/cbic.201300430

Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation

Angelica O. Zabala, Wei Xu, Yit-Heng Chooi and Yi Tang

Chemistry & Biology, 2012, 19, 1049
DOI: 10.1016/j.chembiol.2012.07.004

Endofungal bacteria as producers of mycotoxins

Gerald Lackner, Laila P. Partida-Martinez and Christian Hertweck

Trends in Microbiology, 2009, 17, 570
DOI: 10.1016/j.tim.2009.09.003

Hidden Function of Catalytic Domain in 6-Methylsalicylic Acid Synthase for Product Release

Tomomi Moriguchi, Yuichiro Kezuka, Takamasa Nonaka, Yutaka Ebizuka and Isao Fujii

Journal of Biological Chemistry, 2010, 285, 15637
DOI: 10.1074/jbc.M110.107391

Complexity Generation in Fungal Polyketide Biosynthesis: A Spirocycle-Forming P450 in the Concise Pathway to the Antifungal Drug Griseofulvin

Ralph A. Cacho, Yit-Heng Chooi, Hui Zhou and Yi Tang

ACS Chem. Biol., 2013, 8, 2322
DOI: 10.1021/cb400541z

Culture-based and sequence-based insights into biosynthesis of secondary metabolites by Aspergillus terreus ATCC 20542

Tomasz Boruta and Marcin Bizukojc

Journal of Biotechnology, 2014, 175, 53
DOI: 10.1016/j.jbiotec.2014.01.038

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

Jack Davison, Ahmed al Fahad, Menghao Cai, Zhongshu Song, Samar Y. Yehia, Colin M. Lazarus, Andrew M. Bailey, Thomas J. Simpson and Russell J. Cox

Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 7642
DOI: 10.1073/pnas.1201469109

Isolation and Structure Determination of New Pyrones from Dictyostelium spp. Cellular Slime Molds Coincubated with Pseudomonas spp.

Takehiro Nishimura, Takuya Murotani, Hitomi Sasaki, Yoshinori Uekusa, Hiromi Eguchi, Hirotaka Ishigaki, Katsunori Takahashi, Yuzuru Kubohara and Haruhisa Kikuchi

Molecules, 2024, 29, 2143
DOI: 10.3390/molecules29092143

Regio‐ and Stereoselective Oxidative Phenol Coupling in Aspergillus niger

Christian Gil Girol, Katja M. Fisch, Thorsten Heinekamp, Stefan Günther, Wolfgang Hüttel, Jörn Piel, Axel A. Brakhage and Michael Müller

Angewandte Chemie, 2012, 124, 9926
DOI: 10.1002/ange.201203603

Insights into 6‐Methylsalicylic Acid Bio‐assembly by Using Chemical Probes

James S. Parascandolo, Judith Havemann, Helen K. Potter, Fanglu Huang, Elena Riva, Jack Connolly, Ina Wilkening, Lijiang Song, Peter F. Leadlay and Manuela Tosin

Angewandte Chemie, 2016, 128, 3524
DOI: 10.1002/ange.201509038

First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster

Mary N. Heneghan, Ahmed A. Yakasai, Laura M. Halo, Zhongshu Song, Andrew M. Bailey, Thomas J. Simpson, Russell J. Cox and Colin M. Lazarus

ChemBioChem, 2010, 11, 1508
DOI: 10.1002/cbic.201000259

Domain Organization and Active Site Architecture of a Polyketide SynthaseC-methyltransferase

Meredith A. Skiba, Andrew P. Sikkema, William D. Fiers, William H. Gerwick, David H. Sherman, Courtney C. Aldrich and Janet L. Smith

ACS Chem. Biol., 2016, 11, 3319
DOI: 10.1021/acschembio.6b00759

Roles of cobalt in biosynthesis stimulation of a cytotoxic compound from marine-derived Aspergillus glaucus

Menghao Cai, Xueqian Sun, Xiangshan Zhou and Yuanxing Zhang

Process Biochemistry, 2012, 47, 2267
DOI: 10.1016/j.procbio.2012.09.003

A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca

Takayoshi Awakawa, Takuya Kaji, Toshiyuki Wakimoto and Ikuro Abe

Bioorganic & Medicinal Chemistry Letters, 2012, 22, 4338
DOI: 10.1016/j.bmcl.2012.05.005

Production of a hypothetical polyene substance by activating a cryptic fungal PKS-NRPS hybrid gene in Monascus purpureus

Jae-Won Suh, Bijinu Balakrishnan, Yoon Ji Lim, Doh Won Lee, Jeong Ju Choi, Si-Hyung Park and Hyung-Jin Kwon

JABC, 2018, 61, 83
DOI: 10.3839/jabc.2018.013

Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid

Yasuyo Seshime, Praveen Rao Juvvadi, Katsuhiko Kitamoto, Yutaka Ebizuka, Takamasa Nonaka and Isao Fujii

Bioorganic & Medicinal Chemistry Letters, 2010, 20, 4785
DOI: 10.1016/j.bmcl.2010.06.119

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

Chunjun Zhan, Xiaowei Li, Guangxu Lan, Edward E. K. Baidoo, Yankun Yang, Yuzhong Liu, Yang Sun, Shijie Wang, Yanyan Wang, Guokun Wang, Jens Nielsen, Jay D. Keasling, Yun Chen and Zhonghu Bai

Nat Catal, 2023, 6, 435
DOI: 10.1038/s41929-023-00957-w

The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid

Ahmed al Fahad, Amira Abood, Thomas J. Simpson and Russell J. Cox

Angew Chem Int Ed, 2014, 53, 7519
DOI: 10.1002/anie.201403450

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Michio Sato, Jacob E. Dander, Chizuru Sato, Yiu-Sun Hung, Shu-Shan Gao, Man-Cheng Tang, Leibniz Hang, Jaclyn M. Winter, Neil K. Garg, Kenji Watanabe and Yi Tang

J. Am. Chem. Soc., 2017, 139, 5317
DOI: 10.1021/jacs.7b02432

Characterization of a non-reducing polyketide synthase gene from lichen Dirinaria applanata

R. Valarmathi, G.N. Hariharan, Gayatri Venkataraman and Ajay Parida

Phytochemistry, 2009, 70, 721
DOI: 10.1016/j.phytochem.2009.04.007

Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum

Elizaveta Freinkman, Dong-Chan Oh, Jarrod J. Scott, Cameron R. Currie and Jon Clardy

Tetrahedron Letters, 2009, 50, 6834
DOI: 10.1016/j.tetlet.2009.09.120

The Biosynthetic Logic of Polyketide Diversity

Christian Hertweck

Angew Chem Int Ed, 2009, 48, 4688
DOI: 10.1002/anie.200806121

Xylarins A–D, Two Pairs of Diastereoisomeric Isoindoline Alkaloids from the Endolichenic Fungus Xylaria sp.

Ke Xu, Ruijuan Li, Rongxiu Zhu, Xiaobin Li, Yuliang Xu, Qiaobian He, Fei Xie, Yanan Qiao, Xiaoyi Luan and Hongxiang Lou

Org. Lett., 2021, 23, 7751
DOI: 10.1021/acs.orglett.1c02730

A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi

Robert L Bertrand and John L Sorensen

Journal of Industrial Microbiology and Biotechnology, 2018, 45, 1067
DOI: 10.1007/s10295-018-2080-y

A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae

Hui Zhou, Jixun Zhan, Kenji Watanabe, Xinkai Xie and Yi Tang

Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 6249
DOI: 10.1073/pnas.0800657105

Structural and Biochemical Analysis of Protein–Protein Interactions Between the Acyl‐Carrier Protein and Product Template Domain

Jesus F. Barajas, Kara Finzel, Timothy R. Valentic, Gaurav Shakya, Nathan Gamarra, Delsy Martinez, Jordan L. Meier, Anna L. Vagstad, Adam G. Newman, Craig A. Townsend, Michael D. Burkart and Shiou‐Chuan Tsai

Angewandte Chemie, 2016, 128, 13199
DOI: 10.1002/ange.201605401

Biosynthesis of HSAF, a Tetramic Acid-Containing Macrolactam from Lysobacter enzymogenes

Lili Lou, Guoliang Qian, Yunxuan Xie, Jiliang Hang, Haotong Chen, Kathia Zaleta-Rivera, Yaoyao Li, Yuemao Shen, Patrick H. Dussault, Fengquan Liu and Liangcheng Du

J. Am. Chem. Soc., 2011, 133, 643
DOI: 10.1021/ja105732c

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

Hui Zhou, Zhizeng Gao, Kangjian Qiao, Jingjing Wang, John C Vederas and Yi Tang

Nat Chem Biol, 2012, 8, 331
DOI: 10.1038/nchembio.912

Marilines A–C: Novel Phthalimidines from the Sponge‐Derived Fungus Stachylidium sp.

Celso Almeida, Yasmin Hemberger, Sven Marcel Schmitt, Sarah Bouhired, Lavanya Natesan, Stefan Kehraus, Konstantinos Dimas, Michael Gütschow, Gerhard Bringmann and Gabriele M. König

Chemistry A European J, 2012, 18, 8827
DOI: 10.1002/chem.201103278

Basidiomycete non-reducing polyketide synthases function independently of SAT domains

Nikolai A. Löhr, Malik Rakhmanov, Jacob M. Wurlitzer, Gerald Lackner, Markus Gressler and Dirk Hoffmeister

Fungal Biol Biotechnol, 2023, 10
DOI: 10.1186/s40694-023-00164-z

Microbial synthesis of the type I polyketide 6-methylsalicylate with Corynebacterium glutamicum

Nicolai Kallscheuer, Hirokazu Kage, Lars Milke, Markus Nett and Jan Marienhagen

Appl Microbiol Biotechnol, 2019, 103, 9619
DOI: 10.1007/s00253-019-10121-9

Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus

Liujuan Zheng, Yiling Yang, Haowen Wang, Aili Fan, Liping Zhang and Shu-Ming Li

Org. Lett., 2020, 22, 7837
DOI: 10.1021/acs.orglett.0c02719

Antiosteoporotic Tetrahydroxanthone Dimers from Aspergillus brunneoviolaceusFB‐2 Residing in Human Gut

Xiao Jing Lv, Fei Ding, Ying Jie Wei and Ren Xiang Tan

Chin. J. Chem., 2021, 39, 1580
DOI: 10.1002/cjoc.202100026

Polyketide Skeletons from the Marine Alga‐Derived Fungus Coniothyrium cereale

Mahmoud Fahmi Elsebai, Mamona Nazir, Stefan Kehraus, Ekaterina Egereva, Karine Ndjoko Ioset, Laurence Marcourt, Damien Jeannerat, Michael Gütschow, Jean‐Luc Wolfender and Gabriele M. König

Eur J Org Chem, 2012, 2012, 6197
DOI: 10.1002/ejoc.201200700

Fungi as a Potential Source of Polyketides: A Review

A. Khajuria and S. Nonzom

Appl Biochem Microbiol, 2024, 60, 554
DOI: 10.1134/S0003683823603451

Identification of a Polyketide Synthase Gene Responsible for Ascochitine Biosynthesis in Ascochyta fabae and Its Abrogation in Sister Taxa

Wonyong Kim, Judith Lichtenzveig, Robert A. Syme, Angela H. Williams, Tobin L. Peever, Weidong Chen and Aaron P. Mitchell

mSphere, 2019, 4
DOI: 10.1128/mSphere.00622-19

Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase

Xinkai Xie, Michael J. Meehan, Wei Xu, Pieter C. Dorrestein and Yi Tang

J. Am. Chem. Soc., 2009, 131, 8388
DOI: 10.1021/ja903203g

Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain

Leibniz Hang, Man‐Cheng Tang, Colin J. B. Harvey, Claire G. Page, Jian Li, Yiu‐Sun Hung, Nicholas Liu, Maureen E. Hillenmeyer and Yi Tang

Angew Chem Int Ed, 2017, 56, 9556
DOI: 10.1002/anie.201705237