Issue 34, 2023

Design, strategies, and therapeutics in nanoparticle-based siRNA delivery systems for breast cancer

Abstract

Utilizing small interfering RNA (siRNA) as a treatment for cancer, a disease largely driven by genetic aberrations, shows great promise. However, implementing siRNA therapy in clinical practice is challenging due to its limited bioavailability following systemic administration. An attractive approach to address this issue is the use of a nanoparticle (NP) delivery platform, which protects siRNA and delivers it to the cytoplasm of target cells. We provide an overview of design considerations for using lipid-based NPs, polymer-based NPs, and inorganic NPs to improve the efficacy and safety of siRNA delivery. We focus on the chemical structure modification of carriers and NP formulation optimization, NP surface modifications to target breast cancer cells, and the linking strategy and intracellular release of siRNA. As a practical example, recent advances in the development of siRNA therapeutics for treating breast cancer are discussed, with a focus on inhibiting cancer growth, overcoming drug resistance, inhibiting metastasis, and enhancing immunotherapy.

Graphical abstract: Design, strategies, and therapeutics in nanoparticle-based siRNA delivery systems for breast cancer

Article information

Article type
Review Article
Submitted
10 fev 2023
Accepted
14 iyl 2023
First published
19 iyl 2023

J. Mater. Chem. B, 2023,11, 8096-8116

Design, strategies, and therapeutics in nanoparticle-based siRNA delivery systems for breast cancer

C. Yan, J. Zhang, M. Huang, J. Xiao, N. Li, T. Wang and R. Ling, J. Mater. Chem. B, 2023, 11, 8096 DOI: 10.1039/D3TB00278K

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