Issue 19, 2023

Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

Abstract

With a significant prominence in various strain release transformations, the strained cycloalkanols act as ‘n’ carbon synthons in a multitude of diversified reactions. Their ease of formation, along with facile ring scission through the β-C elimination pathway, foresee various reactivities involving scaffold rearrangements, transition-metal and light-driven transformations, homoenolate mediated chemistry, tandem C–H/C–C bond activations, and so on. This review, therefore, highlights the key developments in the ever-expanding sphere of cycloalkanol chemistry, with key emphasis provided to the higher ring analogues. Prominent breakthroughs since their inception to the recent developments on enantioselective, light-mediated, and electrochemical transformations are also elaborated for the various alkanol systems, thus, featuring their paramount significance.

Graphical abstract: Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

Article information

Article type
Review Article
Submitted
14 iyl 2023
Accepted
16 avq 2023
First published
16 avq 2023

Org. Chem. Front., 2023,10, 4941-4971

Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

N. Jha, P. Mishra and M. Kapur, Org. Chem. Front., 2023, 10, 4941 DOI: 10.1039/D3QO01090B

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