Issue 16, 2023

Recent advances in the photocatalytic synthesis of aldehydes

Abstract

The synthesis of aldehyde compounds under mild conditions enabled by visible light-induced organic reactions is highly attractive in modern chemistry. Reagents including glyoxylic acid (or its derivatives), vinylene carbonate, methylamines, 1,3-dioxolane, and α-chloro N-methoxyphthalimide (PhthOCH2Cl), are found to be sources of the aldehyde group in photocatalytic reactions. This review summarizes the recently developed photocatalytic strategies for the installation of the formyl group into various scaffolds, mainly through the key steps of photocatalytic decarboxylation, oxidation coupling with methylamines/hydrolysis, hydrogen atom transfer of 1,3-dioxolane, and direct generation of formyl radicals.

Graphical abstract: Recent advances in the photocatalytic synthesis of aldehydes

Article information

Article type
Review Article
Submitted
06 iyl 2023
Accepted
11 iyl 2023
First published
12 iyl 2023

Org. Chem. Front., 2023,10, 4198-4210

Recent advances in the photocatalytic synthesis of aldehydes

Y. Wang, X. Liu and W. He, Org. Chem. Front., 2023, 10, 4198 DOI: 10.1039/D3QO01026K

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