Issue 3, 2023

Multi-drug loaded eugenol-based nanoemulsions for enhanced anti-mycobacterial activity

Abstract

Tuberculosis is one of the oldest bacterial infections known to mankind caused by Mycobacterium tuberculosis. The aim of this research is to optimize and formulate a multi-drug loaded eugenol based nanoemulsion system and to evaluate its ability as an antimycobacterial agent and its potential to be a low cost and effective drug delivery system. All the three eugenol based drug loaded nano-emulsion systems were optimized using response surface methodology (RSM)-central composite design (CCD) and were found stable at a ratio of 1 : 5 (oil : surfactant) when ultrasonicated for 8 minutes. The minimum inhibitory concentration (MIC) values against strains of Mycobacterium tuberculosis highly proved that these essential oil-based nano-emulsions showed more promising results and an even improved anti-mycobacterium activity on the addition of a combination of drugs. The absorbance of 1st line anti-tubercular drugs from release kinetics studies showed a controlled and sustained release in body fluids. Thus, we can conclude that this is a much more efficient and desirable method in treating infections caused by Mycobacterium tuberculosis and even its MDR/XDR strains. All these nano-emulsion systems were stable for more than 3 months.

Graphical abstract: Multi-drug loaded eugenol-based nanoemulsions for enhanced anti-mycobacterial activity

Supplementary files

Article information

Article type
Research Article
Submitted
12 sen 2022
Accepted
22 dek 2022
First published
19 yan 2023

RSC Med. Chem., 2023,14, 433-443

Multi-drug loaded eugenol-based nanoemulsions for enhanced anti-mycobacterial activity

P. M. Menon, N. Chandrasekaran, G. P. D. C and S. Shanmugam, RSC Med. Chem., 2023, 14, 433 DOI: 10.1039/D2MD00320A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements