Issue 18, 2022

Nickel-catalyzed hydroarylation reaction: a useful tool in organic synthesis

Abstract

This article describes the recent advances in the field of nickel-catalyzed hydroarylation reaction of alkenes, alkynes, and arenes. All reactions proceeded either through internal hydride transfer or in the presence of an external hydride source. This nickel-catalyzed atom economical hydroarylation reaction exhibited the stereoselectivity and enantioselectivity of the product. The effectiveness of this protocol is in bearing several building blocks, structural motifs for bioactive compounds, natural products, and complex molecule formation. The outlook and mechanistic approaches of these reactions are also discussed.

Graphical abstract: Nickel-catalyzed hydroarylation reaction: a useful tool in organic synthesis

Article information

Article type
Review Article
Submitted
21 may 2022
Accepted
16 iyl 2022
First published
22 iyl 2022

Org. Chem. Front., 2022,9, 5074-5103

Nickel-catalyzed hydroarylation reaction: a useful tool in organic synthesis

S. Bhakta and T. Ghosh, Org. Chem. Front., 2022, 9, 5074 DOI: 10.1039/D2QO00826B

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