Issue 22, 2021

A robust and facile method for desulfonation to amines

Abstract

In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chemical yields. Moreover, the functional groups tested were generally well tolerated.

Graphical abstract: A robust and facile method for desulfonation to amines

Supplementary files

Article information

Article type
Research Article
Submitted
11 avq 2021
Accepted
15 sen 2021
First published
16 sen 2021

Org. Chem. Front., 2021,8, 6182-6186

A robust and facile method for desulfonation to amines

C. Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang and G. Yang, Org. Chem. Front., 2021, 8, 6182 DOI: 10.1039/D1QO01190A

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