Issue 32, 2021

Lysosome targeting, Cr(vi) and l-AA sensing, and cell imaging based on N-doped blue-fluorescence carbon dots

Abstract

N-doped blue-fluorescence carbon dots (N-CDs) were fabricated via a one-pot hydrothermal method using folic acid and p-phenylenediamine. The obtained N-CDs exhibited strong fluorescence (FL) with a considerable quantum yield (QY) of 21.8% and exceptional optical stability under different conditions. Upon introducing Cr(VI), blue FL of N-CDs was distinctly quenched. On subsequent addition of L-AA, the FL of N-CDs could be partially recovered. The fluorescence changes of N-CDs have been utilized to detect Cr(VI) and L-AA in aqueous solutions with linear ranges of 0.10–150 μM and 0.75–2.25 mM, respectively, as well as limit of detection values of 9.4 nM and 25 μM, respectively. Furthermore, as-obtained N-CDs can be extended to monitor the fluctuation of intracellular Cr(VI) and L-AA. More intriguingly, N-CDs can target lysosomes with a satisfactory Pearson correction coefficient of 0.87, which indicates a promising application prospect in the biomedical field.

Graphical abstract: Lysosome targeting, Cr(vi) and l-AA sensing, and cell imaging based on N-doped blue-fluorescence carbon dots

Supplementary files

Article information

Article type
Paper
Submitted
08 iyn 2021
Accepted
13 iyl 2021
First published
13 iyl 2021

Anal. Methods, 2021,13, 3561-3568

Lysosome targeting, Cr(VI) and L-AA sensing, and cell imaging based on N-doped blue-fluorescence carbon dots

L. Shi, X. Dong, G. Zhang, Y. Zhang, C. Zhang, C. Dong and S. Shuang, Anal. Methods, 2021, 13, 3561 DOI: 10.1039/D1AY00977J

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