Issue 13, 2019

Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

Abstract

Herein, we report a new polymorph of amodiaquine dihydrochloride dihydrate obtained via heterogeneous crystallisation. This new polymorph exhibits similarity in molecular conformation as well as in its one-dimensional chain structure with a previously known polymorph, however with a difference in its two-dimensional sheet structure. Although crystal DFT-calculations predict the new form to be thermodynamically less stable compared to the previously known polymorph, the preparation method applied opened up the access to its metastable zone.

Graphical abstract: Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

Supplementary files

Article information

Article type
Communication
Submitted
09 okt 2018
Accepted
27 noy 2018
First published
27 noy 2018

CrystEngComm, 2019,21, 2053-2057

Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

O. D. Putra, A. Pettersen, S. O. Nilsson Lill, D. Umeda, E. Yonemochi, Y. P. Nugraha and H. Uekusa, CrystEngComm, 2019, 21, 2053 DOI: 10.1039/C8CE01720D

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