Issue 14, 2018

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

Abstract

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

Supplementary files

Article information

Article type
Communication
Submitted
17 mar 2018
Accepted
11 iyn 2018
First published
12 iyn 2018

Lab Chip, 2018,18, 1997-2002

Author version available

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

N. Hao, Y. Nie, T. Shen and J. X. J. Zhang, Lab Chip, 2018, 18, 1997 DOI: 10.1039/C8LC00273H

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