Issue 75, 2018

C(sp2)–H Trifluoromethylation of enamides using TMSCF3: access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

Abstract

A method for the direct C(sp2)–H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.

Graphical abstract: C(sp2)–H Trifluoromethylation of enamides using TMSCF3: access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
20 iyn 2018
Accepted
21 avq 2018
First published
29 avq 2018

Chem. Commun., 2018,54, 10574-10577

C(sp2)–H Trifluoromethylation of enamides using TMSCF3: access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles

V. Krishnamurti, S. B. Munoz, X. Ispizua-Rodriguez, J. Vickerman, T. Mathew and G. K. Surya Prakash, Chem. Commun., 2018, 54, 10574 DOI: 10.1039/C8CC04907F

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