Issue 50, 2018

Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

Abstract

Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C–H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a broad functional group tolerance.

Graphical abstract: Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

Supplementary files

Article information

Article type
Communication
Submitted
26 mar 2018
Accepted
25 may 2018
First published
31 may 2018

Chem. Commun., 2018,54, 6935-6938

Transition-metal-free C–H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediates

K. N. Lee, D. N. Spiegowski, J. W. Lee, S. Lim, F. Zhao and M. Ngai, Chem. Commun., 2018, 54, 6935 DOI: 10.1039/C8CC02425A

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