Issue 3, 2017

Flexible assembly of targeting agents on porous magnetic nano-cargos by inclusion complexation for accurate drug delivery

Abstract

Efficient delivery of anticancer drugs to increase the intracellular drug concentration in targeted tissues is urgently needed in cancer chemotherapy, since clinical drugs usually have serious side effects on normal tissues. In this paper, we developed a new method to fabricate multi-functional porous magnetic nano-cargos by grafting PEG/folate onto the surface and storing doxorubicin in the pores of magnetic supraparticles for accurate delivery of anticancer drugs. The anticancer drug doxorubicin was fixed into the porous magnetic cores with acid-sensitive linkers, which can be broken in acidic intracellular environments or organelles; the superficial PEG chains on the magnetic cores not only enhanced the dispersion stability of the nano-cargos but also immobilized folate modified α-cyclodextrin by inclusion complexation, and the α-cyclodextrin derivatives could be flexibly replaced as needed. Remarkable proliferation inhibition of cancer cells and minor side effects on normal cells were achieved due to the controlled drug release manner of the nano-drug system, indicating that this kind of nano-cargo has great potential in cancer chemotherapy for personalized and accurate treatment.

Graphical abstract: Flexible assembly of targeting agents on porous magnetic nano-cargos by inclusion complexation for accurate drug delivery

Supplementary files

Article information

Article type
Research Article
Submitted
10 may 2016
Accepted
27 iyl 2016
First published
07 sen 2016

Mater. Chem. Front., 2017,1, 521-529

Flexible assembly of targeting agents on porous magnetic nano-cargos by inclusion complexation for accurate drug delivery

D. Li, L. Sun, Y. Zhang, M. Yu, J. Guo and C. Wang, Mater. Chem. Front., 2017, 1, 521 DOI: 10.1039/C6QM00049E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements