Issue 3, 2016

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

Abstract

This work focuses on improving the efficacy of photoactivatable Ru complexes for photodynamic therapy by employing cross-linked nanoassemblies (CNAs) as a delivery approach. The effects of complex photoactivation, hydrophobicity, and solution ionic strength and pH on complex loading and release from CNAs were analyzed. The cell cytotoxicity of CNA formulations was similar to free Ru complexes despite reduced or eliminated DNA interactions. The release rate and the amount of each Ru complex released (%) varied inversely with complex hydrophobicity, while the effect of solution ionic strength was dependent on complex hydrophobicity. Premature release of two photoactivatable prodrugs prior to irradiation was believed to account for higher activity in cells studies compared to DNA interaction studies; however, for photostable 1O2 generator-loaded CNAs this cannot explain the high cytotoxicity and lack of DNA interactions because release was incomplete after 48 h. The cause remains unclear, but among other possibilities, accelerated release in a cell culture environment may be responsible.

Graphical abstract: Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

Supplementary files

Article information

Article type
Paper
Submitted
10 avq 2015
Accepted
30 noy 2015
First published
01 dek 2015

J. Mater. Chem. B, 2016,4, 394-408

Author version available

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

M. Dickerson, B. Howerton, Y. Bae and E. C. Glazer, J. Mater. Chem. B, 2016, 4, 394 DOI: 10.1039/C5TB01613D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements