Issue 25, 2016

Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

Abstract

The controlled synthesis of functional nanoparticles with tunable structures and properties has been extensively investigated for cancer treatment and diagnosis. Among a variety of methods for fabrication of nanoparticles, microfluidics-based synthesis enables enhanced mixing and precise fluidic modulation inside microchannels, thus allowing for the flow-mediated production of nanoparticles in a controllable manner. This review focuses on recent advances of using microfluidic devices for the synthesis of drug-loaded nanoparticles with specific characteristics (such as size, composite, surface modification, structure and rigidity) for enhanced cancer treatment and diagnosis as well as to investigate the bio-nanoparticle interaction. The discussion on microfluidics-based synthesis may shed light on the rational design of functional nanoparticles for cancer-related pharmaceutical applications.

Graphical abstract: Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

Article information

Article type
Review Article
Submitted
11 noy 2015
Accepted
25 yan 2016
First published
26 yan 2016

Nanoscale, 2016,8, 12430-12443

Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

Q. Feng, J. Sun and X. Jiang, Nanoscale, 2016, 8, 12430 DOI: 10.1039/C5NR07964K

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