Issue 30, 2012

Methylthioxylose – a jewel in the mycobacterial crown?

Abstract

Ten years ago an unusual sugar was discovered in a cell wall polysaccharide of Mycobacterium tuberculosis. Structural elucidation revealed the presence of the first thiosugar in a bacterial polysaccharide. Synthetic studies have helped to define its relative and absolute configuration as α-D-methylthioxylofuranosyl. While its biosynthetic origins remain the subject of speculation, work has begun to define its possible biological roles.

Graphical abstract: Methylthioxylose – a jewel in the mycobacterial crown?

Article information

Article type
Perspective
Submitted
27 mar 2012
Accepted
12 apr 2012
First published
10 may 2012

Org. Biomol. Chem., 2012,10, 5698-5706

Methylthioxylose – a jewel in the mycobacterial crown?

W. B. Turnbull and S. A. Stalford, Org. Biomol. Chem., 2012, 10, 5698 DOI: 10.1039/C2OB25630D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements