Issue 1, 2012

Alkaline phosphatase enzymatic signal amplification for fast, sensitive impedimetric DNA detection

Abstract

Enzymatic signal amplification by the deposition of insoluble product on the electrode surface enhances impedimetric DNA detection sensitivity. This work demonstrates a method which gives the required detection sensitivity at significantly reduced enzyme reaction times, and demonstrates the capability for DNA SNP discrimination of biologically relevant sequences. This opens up the prospect of more rapid and relevant multiparameter impedimetric bioassays.

Graphical abstract: Alkaline phosphatase enzymatic signal amplification for fast, sensitive impedimetric DNA detection

Article information

Article type
Communication
Submitted
23 avq 2011
Accepted
06 okt 2011
First published
19 okt 2011

Analyst, 2012,137, 59-63

Alkaline phosphatase enzymatic signal amplification for fast, sensitive impedimetric DNA detection

M. Kaatz, H. Schulze, I. Ciani, F. Lisdat, A. R. Mount and T. T. Bachmann, Analyst, 2012, 137, 59 DOI: 10.1039/C1AN15767A

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