X-ray Responsive Therapeutic Systems in Tumor Treatments

Abstract

Due to its high energy and deep tissue penetration, X-ray is an ideal stimulus source for diagnosis and therapy. In the field of cancer treatment, by reasonably designing and using systems with X-ray responsiveness, it is possible to improve treatment methods or combine multiple treatment modalities, thereby improving treatment effectiveness and reducing side effects. This review aims to summarize the research progress of X-ray responsiveness in the field of cancer treatment in recent years. Specifically, the promotion of X-ray responsive radiosensitizers on X-ray radiation therapy itself was introduced, as well as the combination of radiotherapy and other cancer therapies mediated by X-ray responsive therapeutic systems, which mainly includes the combination of radiotherapy and photodynamic therapy through X-ray responsive scintillators and the combination of radiotherapy and chemotherapy through X-ray responsive drug delivery systems.

Transparent peer review

To support increased transparency, we offer authors the option to publish the peer review history alongside their article.

View this article’s peer review history

Article information

Article type
Review Article
Submitted
02 Oct 2025
Accepted
17 Nov 2025
First published
19 Nov 2025

J. Mater. Chem. B, 2025, Accepted Manuscript

X-ray Responsive Therapeutic Systems in Tumor Treatments

R. Sun, Y. Cheng and T. Zhang, J. Mater. Chem. B, 2025, Accepted Manuscript , DOI: 10.1039/D5TB02224J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements