Issue 8, 2024

First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines

Abstract

Caerulomycins, natural alkaloids with antimicrobial properties, have been previously synthesized starting with highly pre-functionalized building blocks or requiring many functional group manipulations. In this work, we report the first total synthesis of caerulomycin K, a diversely trifunctionalized pyridine readily assembled in three steps exploiting the recent advancements in the C–H activation of N-heterocycles.

Graphical abstract: First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines

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Article information

Article type
Paper
Submitted
23 yan 2024
Accepted
31 yan 2024
First published
13 fev 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 5542-5546

First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines

A. Dimasi, M. Failla, A. Montoli, A. Citarella, P. Ronchi, D. Passarella and V. Fasano, RSC Adv., 2024, 14, 5542 DOI: 10.1039/D4RA00589A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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