Issue 33, 2024

Magnetic iron oxide nanogels for combined hyperthermia and drug delivery for cancer treatment

Abstract

Hyperthermia and chemotherapy represent potential modalities for cancer treatments. However, hyperthermia can be invasive, while chemotherapy drugs often have severe side effects. Recent clinical investigations have underscored the potential synergistic efficacy of combining hyperthermia with chemotherapy, leading to enhanced cancer cell killing. In this context, magnetic iron oxide nanogels have emerged as promising candidates as they can integrate superparamagnetic iron oxide nanoparticles (IONPs), providing the requisite magnetism for magnetic hyperthermia, with the nanogel scaffold facilitating smart drug delivery. This review provides an overview of the synthetic methodologies employed in fabricating magnetic nanogels. Key properties and designs of these nanogels are discussed and challenges for their translation to the clinic and the market are summarised.

Graphical abstract: Magnetic iron oxide nanogels for combined hyperthermia and drug delivery for cancer treatment

Article information

Article type
Review Article
Submitted
13 may 2024
Accepted
25 iyl 2024
First published
26 iyl 2024
This article is Open Access
Creative Commons BY license

Nanoscale, 2024,16, 15446-15464

Magnetic iron oxide nanogels for combined hyperthermia and drug delivery for cancer treatment

S. Patri, N. T. K. Thanh and N. Kamaly, Nanoscale, 2024, 16, 15446 DOI: 10.1039/D4NR02058H

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