Issue 4, 2024

“Clickable” graphene nanoribbons for biosensor interfaces

Abstract

We report on the synthesis of “clickable” graphene nanoribbons (GNRs) and their application as a versatile interface for electrochemical biosensors. GNRs are successfully deposited on gold-coated working electrodes and serve as a platform for the covalent anchoring of a bioreceptor (i.e., a DNA aptamer), enabling selective and sensitive detection of Interleukin 6 (IL6). Moreover, when applied as the intermediate linker on reduced graphene oxide (rGO)-based field-effect transistors (FETs), the GNRs provide improved robustness compared to conventional aromatic bi-functional linker molecules. GNRs enable an orthogonal and covalent attachment of a recognition unit with a considerably higher probe density than previously established methods. Interestingly, we demonstrate that GNRs introduce photoluminescence (PL) when applied to rGO-based FETs, paving the way toward the simultaneous optical and electronic probing of the attached biointerface.

Graphical abstract: “Clickable” graphene nanoribbons for biosensor interfaces

Supplementary files

Article information

Article type
Communication
Submitted
28 dek 2023
Accepted
05 fev 2024
First published
22 fev 2024
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2024,9, 598-608

“Clickable” graphene nanoribbons for biosensor interfaces

R. Hasler, G. E. Fenoy, A. Götz, V. Montes-García, C. Valentini, Z. Qiu, C. Kleber, P. Samorì, K. Müllen and W. Knoll, Nanoscale Horiz., 2024, 9, 598 DOI: 10.1039/D3NH00590A

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