Issue 50, 2024

Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis

Abstract

The C(sp3)–N bond is ubiquitous in natural products, pharmaceuticals, biologically active molecules and functional materials. Consequently, the development of practical and efficient methods for C(sp3)–N bond formation has attracted more and more attention. Compared to the conventional ionic pathway-based thermal methods, photochemical processes that proceed through radical mechanisms by merging photoredox and transition-metal catalyses have emerged as powerful and alternative tools for C(sp3)–N bond formation. In this review, recent advances in the burgeoning field of C(sp3)–N bond formation via metallaphotoredox catalysis have been highlighted. The contents of this review are categorized according to the transition metals used (copper, nickel, cobalt, palladium, and iron) together with photocatalysis. Emphasis is placed on methodology achievements and mechanistic insight, aiming to inspire chemists to invent more efficient radical-involved C(sp3)–N bond-forming reactions.

Graphical abstract: Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis

Article information

Article type
Highlight
Submitted
25 apr 2024
Accepted
24 may 2024
First published
24 may 2024

Chem. Commun., 2024,60, 6340-6361

Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis

J. Zhang, X. Huan, X. Wang, G. Li, W. Xiao and J. Chen, Chem. Commun., 2024, 60, 6340 DOI: 10.1039/D4CC01969E

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