Issue 32, 2023

Two-dimensional TiO nanosheets with photothermal effects for wound sterilization

Abstract

To combat multidrug-resistant bacteria, researchers have poured into the development and design of antimicrobial agents. Here, low-cost two-dimensional (2D) antibacterial material titanium monoxide nanosheets (TiO NSs) were prepared by an ultrasonic-assisted liquid-phase exfoliation method. When cultured with bacteria, TiO NSs showed intrinsic antimicrobial capacity, possibly due to membrane damage caused by the sharp edges of TiO NSs. Under near-infrared (NIR) laser irradiation, TiO NSs showed high photothermal conversion efficiency (PTCE) and sterilization efficiency. By combining these two antibacterial mechanisms, TiO NSs exhibited a strong killing effect on Gram-negative Escherichia coli (E. coli) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Especially after treatment with TiO NSs (150 μg mL−1) +near-infrared (NIR) light irradiation, both bacteria were completely killed. In vivo experiments on wound repair of bacterial infection further confirmed its antibacterial effect. In addition, TiO NSs had no obvious toxicity or side effects, so as a kind of broad-spectrum 2D antibacterial nanoagent, TiO NSs have broad application prospects in the field of pathogen infection.

Graphical abstract: Two-dimensional TiO nanosheets with photothermal effects for wound sterilization

Supplementary files

Article information

Article type
Paper
Submitted
23 may 2023
Accepted
16 iyl 2023
First published
18 iyl 2023

J. Mater. Chem. B, 2023,11, 7641-7653

Two-dimensional TiO nanosheets with photothermal effects for wound sterilization

W. Zhang, H. Chen, H. Tian, Q. Niu, J. Xing, T. Wang, X. Chen and X. Wang, J. Mater. Chem. B, 2023, 11, 7641 DOI: 10.1039/D3TB01170D

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