Issue 24, 2023

Nanotubes and water-channels from self-assembling dipeptides

Abstract

Dipeptides are attractive building blocks for biomaterials in light of their inherent biocompatibility, biodegradability, and simplicity of preparation. Since the discovery of diphenylalanine (Phe-Phe) self-assembling ability into nanotubes, research efforts have been devoted towards the identification of other dipeptide sequences capable of forming these interesting nanomorphologies, although design rules towards nanotube formation are still elusive. In this review, we analyze the dipeptide sequences reported thus far for their ability to form nanotubes, which often feature water-filled supramolecular channels as revealed by single-crystal X-ray diffraction, as well as their properties, and their potential biological applications, which span from drug delivery and regenerative medicine, to bioelectronics and bioimaging.

Graphical abstract: Nanotubes and water-channels from self-assembling dipeptides

Article information

Article type
Review Article
Submitted
03 dek 2022
Accepted
03 fev 2023
First published
08 fev 2023

J. Mater. Chem. B, 2023,11, 5378-5389

Nanotubes and water-channels from self-assembling dipeptides

O. Bellotto, P. D’Andrea and S. Marchesan, J. Mater. Chem. B, 2023, 11, 5378 DOI: 10.1039/D2TB02643K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements